Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation [0.03%]
MYC表达诱导浆细胞分化过程中的特殊转录状态
Panagiota Vardaka,Ben Kemp,Sophie Stephenson et al.
Panagiota Vardaka et al.
MYC provides a rheostat linking cell growth and division. Deregulation of MYC drives transformation in aggressive B-cell neoplasms, often accompanied by BCL2-mediated apoptotic protection. We assess how MYC and BCL2 deregulation impacts on ...
PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses [0.03%]
PTEN调节泌尿道感染的易感性并塑形尿路上皮抗菌防御系统
Aaron Simoni,M Skye Bochter,Sarah Linn-Peirano et al.
Aaron Simoni et al.
Despite advancements in our understanding of urinary tract infection (UTI) pathogenesis, UTIs remain a leading cause of morbidity, partly because of an incomplete understanding of the molecular pathways governing bladder antibacterial defen...
The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density [0.03%]
HINT1的核质穿梭调节细胞密度成熟现象
Xiaofang Zhang,Fumihiko Nakamura
Xiaofang Zhang
In normal epithelial cells on tissue culture dishes, contact inhibition typically progresses with a reduction in cell size after cell-cell contact. This transition involves actin cytoskeleton reorganization from stress fibers (SFs) to a cor...
STAT1-IFITM3 promotes autophagy in epithelial cells to control Cryptosporidium parvum infection [0.03%]
STAT1-IFITM3通过促进上皮细胞自噬来控制隐孢子虫感染
Lijun Cui,Teng Li,Jing Zhang et al.
Lijun Cui et al.
Cryptosporidium parvum infects intestinal epithelial cells, causing cryptosporidiosis in humans and neonatal livestock. Autophagy is an important component of the defense against C. parvum infection. IFITM3 is an IFN-stimulated gene that re...
PRMT1 oligomerization regulates RNA-binding protein cascade to promote pancreatic cancer [0.03%]
PRMT1寡聚化调节RNA结合蛋白级联反应以促进胰腺癌发展
Yanxia Ru,Xinyi Zhou,Xijiao Wang et al.
Yanxia Ru et al.
PRMT1 is the predominant type I protein arginine methyltransferase responsible for generating monomethylarginine and asymmetric dimethylarginine (MMA and ADMA) in various protein substrates. It regulates numerous biological processes, inclu...
Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation [0.03%]
关于大鼠白细胞介素34基因突变影响巨噬细胞发育、稳态和炎症的更正文章
Stephen Huang,Omkar L Patkar,Sarah Schulze et al.
Stephen Huang et al.
Published Erratum
Life science alliance. 2025 Jul 16;8(10):e202503435. DOI:10.26508/lsa.202503435 2025
Multiple domains of scaffold Tudor protein play nonredundant roles in Drosophila germline [0.03%]
支架蛋白Tudor的不同功能域在果蝇生殖系中的作用不同
Samuel J Tindell,Alyssa G Boeving,Julia Aebersold et al.
Samuel J Tindell et al.
Scaffold proteins play crucial roles in subcellular organization and function. In many organisms, proteins with multiple Tudor domains are required for the assembly of membraneless RNA-protein organelles (germ granules) in germ cells. Tudor...
The rewiring of cAMP/cGMP and LDH signalling drives cardiac hypertrophy in Pde5a -/- mice [0.03%]
Pde5a基因敲除小鼠中环磷酸腺苷/鸟苷酸和乳酸脱氢酶信号重编程导致心脏肥大
Ana Gabriela de Oliveira do Rêgo,Sonia Maccari,Giuseppe Marano et al.
Ana Gabriela de Oliveira do Rêgo et al.
Phosphodiesterase type 5a (Pde5a), an enzyme that hydrolyzes cGMP nucleotide, regulates several aspects of heart physiology and its inhibition improves left ventricular heart function under pathological conditions. We investigated Pde5a rol...
A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings [0.03%]
一种用于资源匮乏环境的冷冻干燥型开源RT-LAMP分子诊断检测试剂盒
Martin Matl,Max J Kellner,Felix Ansah et al.
Martin Matl et al.
A critical bottleneck for equitable access to population-scale molecular diagnostics is the limited availability of rapid, inexpensive point-of-care tests, especially in low- and middle-income countries. Here, we developed an open-source re...
In vivo detection of antisense HIV-1 transcripts in untreated and ART-treated individuals [0.03%]
未经处理和接受抗逆转录病毒治疗的个体中HIV-1反义链转录本的体内检测
Adam A Capoferri,Rachel Sklutuis,Toluleke O Famuyiwa et al.
Adam A Capoferri et al.
Natural antisense transcripts (AST) are expressed in eukaryotes, prokaryotes, and viruses and can possess regulatory functions at the transcriptional and/or post-transcriptional levels. In vitro studies have shown that HIV-1 AST promote vir...