Critical roles of Drosophila ubiquitin carboxyl-terminal hydrolase in eye development [0.03%]
果蝇泛素羧基末端水解酶在眼睛发育中的关键作用
Trang Thi Thuy Cao,Tuan Anh Nguyen,Minh Huy Cong Nguyen et al.
Trang Thi Thuy Cao et al.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a protein in the ubiquitin-proteasome system involved in numerous cellular processes and implicated in various human diseases, including cancer, neurodegenerative diseases, and metabolic syndrom...
Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes [0.03%]
SASS6表达失调促进过度形成纤毛和细胞侵袭表型
Eleanor Hargreaves,Rebecca Collinson,Andrew D Jenks et al.
Eleanor Hargreaves et al.
Centriole and/or cilium defects are characteristic of cancer cells and have been linked to cancer cell invasion. However, the mechanistic bases of this regulation remain incompletely understood. Spindle assembly abnormal protein 6 homolog (...
Developmental system drift and modular gene regulatory networks shape gastrulation in Acropora [0.03%]
发育系统漂移和模块化基因调控网络塑造了Acropora的原肠胚形成过程
Juan P Ossa-Gómez,Héctor A Rodríguez-Cabal,Alejandro Reyes-Bermúdez
Juan P Ossa-Gómez
Although gastrulation is a conserved morphogenetic process in animals, the cellular mechanisms underlying it are highly variable. This raises important questions regarding the extent to which conserved or divergent gene regulatory programs ...
The -10 region adjacent to open reading frames is a common expression pattern in Deinococcus-Thermus [0.03%]
脱氧胞病毒-嗜热菌纲开放阅读框附近的-10区域是一种常见的表达模式
Shitong Zhong,Linjia Wang,Shuang Song et al.
Shitong Zhong et al.
Gene transcription and translation are fundamental processes that underpin the vitality of living organisms. In bacteria, the classic promoter elements for transcription include the -35 region and the -10 region, whereas the ribosome bindin...
Up-regulated chitinase-like protein-1 promotes tumour growth while physiological levels are protective [0.03%]
上调的类几丁质酶-1蛋白促进肿瘤生长而生理水平具有保护作用
Shuangye Yan,Sam Holt,Xiao Gao et al.
Shuangye Yan et al.
The human and mouse orthologues CHI3L1/Chil1 encode a chitinase-related protein that is catalytically inactive. It is overexpressed in multiple inflammatory disorders and cancers and is thought to be pro-inflammatory and immune modulatory, ...
Epigenetic liquid biopsies reveal endothelial turnover and erythropoiesis in asymptomatic COVID-19 [0.03%]
无症状新冠病毒感染的表观遗传液体活检揭示了内皮细胞更新和红细胞生成过程中的变化
Roni Ben-Ami,Netanel Loyfer,Eden Cohen et al.
Roni Ben-Ami et al.
Understanding the full spectrum of tissues affected by SARS-CoV-2 is crucial for deciphering the heterogeneous clinical course of COVID-19. We analyzed DNA methylation and histone modifications in circulating chromatin to assess cell type-s...
Characterisation of the manchette architecture and its role as transport scaffold using cryo-electron tomography [0.03%]
利用冷冻电镜断层扫描技术表征鞭毛前体小管的结构并探讨其作为运输支架的作用
Jo H Judernatz,Laura Pérez Pañeda,Tereza Kadavá et al.
Jo H Judernatz et al.
The development of correctly shaped sperm cells is crucial for male reproductive health and fertility. The manchette is a transient microtubule-based structure that assembles during spermiogenesis and contributes to sperm head shaping. Defe...
Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue [0.03%]
通过支架残基调节RING型E3泛素连接酶的泛素转移活性
Mark A Nakasone,Lori Buetow,Mads Gabrielsen et al.
Mark A Nakasone et al.
RING family ubiquitin ligases (E3s) employ the RING domain to recruit the E2 thioester ubiquitin (E2∼Ub) intermediate to catalyze the transfer of ubiquitin (Ub) to substrates. A cationic Arg linchpin (LP) residue in the RING domain plays a...
Integrative transcriptomic analysis reveals oligodendrocyte lineage switching in multiple sclerosis [0.03%]
整合转录组分析揭示了多发性硬化病中少突胶质细胞谱系的转换
Zhong-Ze Yan,Pei-Pei Liu,Hong-Zhen Du et al.
Zhong-Ze Yan et al.
Multiple sclerosis (MS) is a chronic disease of the central nervous system. The occurrence of MS is a phased process while its cause is still unclear. Here, by combining white matter single-nucleus transcriptomic datasets from MS and contro...
Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2-mutant mesothelioma [0.03%]
评估YAP-TEAD抑制剂的流程表明TEAD抑制可抑制NF2基因突变型间皮瘤
Richard Cunningham,Siyang Jia,Krishna Purohit et al.
Richard Cunningham et al.
As the core, tumorigenic downstream effectors of the Hippo signalling pathway, YAP/TAZ and the TEAD family of transcription factors represent attractive targets for drug discovery efforts within cancer research. This is particularly true in...