Genome-scale prediction of gene ontology from mass fingerprints reveals new metabolic gene functions [0.03%]
从质量指纹预测基因本体揭示新的代谢基因功能
Christopher J Vavricka,Masao Mochizuki,Satoshi Yuzawa et al.
Christopher J Vavricka et al.
Mass-based fingerprinting can characterize microorganisms; however, expansion of these methods to predict specific gene functions is lacking. Therefore, mass fingerprinting was developed to functionally profile a yeast knockout library. Mat...
Elucidating the role of human skeletal muscles in the pathogenesis of enterovirus D68 infection [0.03%]
人骨骼肌在EV-D68感染发病机制中的作用研究
Brigitta M Laksono,Atze J Bergsma,Alessandro Iuliano et al.
Brigitta M Laksono et al.
Enterovirus D68 (EV-D68) is an emerging respiratory virus associated with extra-respiratory complications, especially acute flaccid myelitis. However, the pathogenesis of acute flaccid myelitis is not fully understood. It is hypothesised th...
Differential cell survival outcomes in response to diverse amino acid stress [0.03%]
针对不同氨基酸胁迫应答的细胞存活结果的差异性分析
Marion Russier,Alessandra Fiore,Ana Bici et al.
Marion Russier et al.
Amino acid (AA) detection is fundamental for cellular function, balancing translation demands, biochemical pathways, and signaling networks. Although the GCN2 and mTORC1 pathways are known to regulate AA sensing, the global cellular respons...
γδ T cells are the prime antitumoral T cells in pediatric neuroblastoma [0.03%]
γδT细胞是儿童神经母细胞瘤中的主要抗肿瘤T细胞
Suzanne M Castenmiller,Anne L Borst,Leyma Wardak et al.
Suzanne M Castenmiller et al.
High-risk pediatric neuroblastoma patients have a dismal survival rate despite intensive treatment regimens. New treatment options are thus required. Even though HLA expression in neuroblastoma is low and immune cell infiltrates are limited...
Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction [0.03%]
天冬氨酸依赖的TSC2去磷酸化通过溶酶体PP2A调节mTORC1信号转导
Takanori Nakamura,Shigeyuki Nada,Masaki Matsumoto et al.
Takanori Nakamura et al.
The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, composed of amino acid (AA)-sensing (Ragulator/LAMTOR-Rag) and growth factor (GF)-sensing (AKT-TSC1/2-Rheb) axes, pivotally regulates intracellular anabolism and catabo...
Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury [0.03%]
脊髓损伤后GlcNAc6ST1和GlcNAc6ST4缺失小鼠的运动功能恢复增强
Masayoshi Morozumi,Tomoya Ozaki,Kazuchika Nishitsuji et al.
Masayoshi Morozumi et al.
Spinal cord injury (SCI) damages neural circuits and triggers pro-inflammatory responses, resulting in locomotor impairment. The carbohydrate sulfotransferases GlcNAc6ST1 and GlcNAc6ST4 modulate the function of blood monocytes and microglia...
Protein arginine methyltransferase 5 sustains Tip60-EP400 complex via SRSF1 in Merkel cell carcinoma [0.03%]
精氨酸甲基转移酶5通过SRSF1维持Tip60-EP400复合体在 Merkel 细胞癌中的作用
Joseph L Sevigny,Evelyn V Proctor,Heather Adams et al.
Joseph L Sevigny et al.
Protein arginine methyltransferase 5 (PRMT5) is a key regulator of gene expression and RNA splicing, with therapeutic potential demonstrated in MTAP-deleted cancers. Emerging evidence suggests that MYC-driven tumors or tumors with wild-type...
Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer [0.03%]
Wnt10b信号转导调控人类癌症中的复制压力引起的染色体不稳定性
Alexander Haas,Friederike Wenz,Janina Hattemer et al.
Alexander Haas et al.
Wnt signaling pathways are involved in various developmental and tissue maintenance functions, whereas deregulated Wnt signaling is closely linked to human cancer. Recent work revealed that loss of Wnt signaling impairs mitosis and causes a...
Alyssa A Rodriguez,Alessandro E Cirulli,Katie Chau et al.
Alyssa A Rodriguez et al.
In meiosis, ploidy reduction is driven by a complex series of DNA breakage and recombination events between homologous chromosomes, orchestrated by meiotic HORMA domain proteins (HORMADs). Meiotic HORMADs possess a central chromatin binding...
Fission yeast Rad54 prevents intergenerational buildup of Rad51 aggregates in proliferating cells [0.03%]
裂解酵母Rad54可防止在增殖细胞中积累Rad51世代聚集物
Goki Taniguchi,Alexander I May,Hiroshi Iwasaki et al.
Goki Taniguchi et al.
Homologous recombination is central to the maintenance of genome stability. Using fission yeast, we found that mutation of the rad54 gene leads to robust Rad51 accumulation in vegetatively growing cells. By developing a protocol to track Ra...