Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model [0.03%]
人乳可通过肠道模型抑制某些具包膜病毒的感染，包括新冠病毒感冒
Ikrame Aknouch,Adithya Sridhar,Eline Freeze et al.
Ikrame Aknouch et al.
Human milk is important for antimicrobial defense in infants and has well demonstrated antiviral activity. We evaluated the protective ability of human milk against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a...
A protective role for <i>Drosophila</i> Filamin in nephrocytes via Yorkie mediated hypertrophy [0.03%]
Filamin通过Yorkie介导的细胞肥大在果蝇肾细胞中发挥保护作用
Sybille Koehler,Tobias B Huber,Barry Denholm
Sybille Koehler
Podocytes are specialized epithelial cells of the kidney glomerulus and are an essential part of the filtration barrier. Because of their position, they are exposed to constant biomechanical forces such as shear stress and hydrostatic press...
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia [0.03%]
基于二维分化鼻上皮的类器官测量囊性纤维化药物反应
Gimano D Amatngalim,Lisa W Rodenburg,Bente L Aalbers et al.
Gimano D Amatngalim et al.
Cystic fibrosis is caused by genetic defects that impair the CFTR channel in airway epithelial cells. These defects may be overcome by specific CFTR modulating drugs, for which the efficacy can be predicted in a personalized manner using 3D...
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease [0.03%]
染色体21蛋白质-蛋白质相互作用：智力障碍、自闭症和老年痴呆相关蛋白的富集现象
Julia Viard,Yann Loe-Mie,Rachel Daudin et al.
Julia Viard et al.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and th...
RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability [0.03%]
单胆管细胞衍生器官的RNA测序揭示了高器官间差异性
Kristin Gehling,Swati Parekh,Farina Schneider et al.
Kristin Gehling et al.
Over the last decades, organoids have been established from most of the tissue-resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalised...
Insight into the mechanism of DNA synthesis by human terminal deoxynucleotidyltransferase [0.03%]
人端粒脱氧核苷酸转移酶DNA合成机制的探究
Aleksandra A Kuznetsova,Timofey E Tyugashev,Irina V Alekseeva et al.
Aleksandra A Kuznetsova et al.
Terminal deoxynucleotidyltransferase (TdT) is a member of the DNA polymerase X family that is responsible for random addition of nucleotides to single-stranded DNA. We present investigation into the role of metal ions and specific interacti...
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma [0.03%]
PFKFB4与ICMT相互作用并通过RAS/AKT信号依赖性细胞迁移激活黑色素瘤中的信号传导
Méghane Sittewelle,Vincent Kappès,Chenxi Zhou et al.
Méghane Sittewelle et al.
Cell migration is a complex process, tightly regulated during embryonic development and abnormally activated during cancer metastasis. RAS-dependent signaling is a major nexus controlling essential cell parameters including proliferation, s...
Novel <i>DNM1L</i> variants impair mitochondrial dynamics through divergent mechanisms [0.03%]
新型DNM1L变异体通过不同的机制损害线粒体动力学
Kelsey A Nolden,John M Egner,Jack J Collier et al.
Kelsey A Nolden et al.
Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin-related protein 1 (DRP1) oligomerisation and membrane constricti...
Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist [0.03%]
肝细胞生长因子/散射因子第1kringle结构域的二聚作用能够提供一种强大的MET受体激动剂
Giovanni de Nola,Bérénice Leclercq,Alexandra Mougel et al.
Giovanni de Nola et al.
Hepatocyte growth factor/scatter factor (HGF/SF) and its cognate receptor MET play several essential roles in embryogenesis and regeneration in postnatal life of epithelial organs such as the liver, kidney, lung, and pancreas, prompting a s...
RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance [0.03%]
PCNA修饰介导的DNA损伤耐受依赖于RFWD3和跨损伤DNA聚合酶
Rie Kanao,Hidehiko Kawai,Toshiyasu Taniguchi et al.
Rie Kanao et al.
DNA damage tolerance pathways are regulated by proliferating cell nuclear antigen (PCNA) modifications at lysine 164. Translesion DNA synthesis by DNA polymerase η (Polη) is well studied, but less is known about Polη-independent mechanis...