SNRK: a metabolic regulator with multifaceted role in development and disease [0.03%]
SNRK：发育与疾病中具有多样作用的代谢调节器
Karthikeyan Thirugnanam,Ramani Ramchandran
Karthikeyan Thirugnanam
Sucrose nonfermenting 1-related kinase (SNRK) is a serine/threonine kinase and a member of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) family that is involved in the metabolic regulatory mechanisms in various cell type...
Surgical treatment for heart failure: cell-based therapy with engineered tissue [0.03%]
心脏衰竭的外科治疗：以工程组织为基础的细胞治疗
Jordan J Lancaster,Jen Watson Koevary,Ikeotunye Royal Chinyere et al.
Jordan J Lancaster et al.
This review will outline cell-based therapy for heart failure focusing on tissue engineering to deliver cells to the damaged heart. We will present an overview of the central approaches focusing on pluripotent stem cell-derived cells, mecha...
Nils Ludwig,Edwin K Jackson,Theresa L Whiteside
Nils Ludwig
The role of exosomes in different physiological and pathological settings is an emerging field of great current interest. One hallmark of exosomes is the promotion of blood vessel formation. Exosomes of different cellular origin have been s...
Histone deacetylases in vascular permeability and remodeling associated with acute lung injury [0.03%]
与急性肺损伤相关的血管通透性和重塑的组蛋白脱乙酰酶的研究
Laszlo Kovacs,Anita Kovacs-Kasa,Alexander D Verin et al.
Laszlo Kovacs et al.
Acute lung injury (ALI) is a severe progressive disorder that arises from a wide range of causes such as toxins or inflammation, resulting in significant morbidity and mortality. There are no effective therapeutic options apart from mechani...
A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention [0.03%]
当前从GPCRs介导的信号转导方面看待肺动脉高压：发现潜在治疗途径
Derek Strassheim,Vijaya Karoor,Kurt Stenmark et al.
Derek Strassheim et al.
Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertr...
A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention [0.03%]
当前从信号转导角度看待肺动脉高压中G蛋白偶联受体的研究：寻找潜在的治疗切入点
Derek Strassheim,Vijaya Karoor,Kurt Stenmark et al.
Derek Strassheim et al.
Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertr...
Akhil Padarti,Jun Zhang
Akhil Padarti
Cerebral cavernous malformations (CCM) are manifested by microvascular lesions characterized by leaky endothelial cells with minimal intervening parenchyma predominantly in the central nervous system predisposed to hemorrhagic stroke, resul...
Immunohistochemistry of the circadian clock in mouse and human vascular tissues [0.03%]
小鼠和人类血管组织中的昼夜钟免疫组化分析
Ciprian B Anea,Ana M Merloiu,David J R Fulton et al.
Ciprian B Anea et al.
Aim: The circadian clock is a molecular network that controls the body physiological rhythms. In blood vessels, the circadian clock components modulate vascular remodeling, blood pressure, and signaling. The goal in this ...
Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling [0.03%]
基于_epsin_的泛素相互作用模体的拟肽作为抗癌药物治疗脑瘤的新策略：通过调节VEGFR2信号通路起效
Yunzhou Dong,Hao Wu,Jerry Dong et al.
Yunzhou Dong et al.
Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human cancers. It has been characterized that mice deficient of epsins in the endothelium inhibit tumor growth by dysre...