Multicenter randomized controlled trial of exercise in aortic dissection survivors: rationale, design, and initial hemodynamic data [0.03%]
主动脉夹层幸存者运动治疗的多中心随机对照试验：立论、设计和初始血流动力学数据
Yasmin A Toy,Kayla N House,Leslie M Boyer et al.
Yasmin A Toy et al.
Aims: There are currently no evidence-based guidelines for exercise after thoracic aortic dissection (TAD), leading to highly variable recommendations that frequently lead patients to restrict their physical activities. T...
Intracranial aneurysm segmentation with nnU-net: utilizing loss functions and automated vessel extraction [0.03%]
基于nnU-Net的颅内动脉瘤分割：利用损失函数和自动血管提取技术
Maysam Orouskhani,Negar Firoozeh,Huayu Wang et al.
Maysam Orouskhani et al.
Aim: Intracranial aneurysms pose significant challenges in diagnosis and treatment, emphasizing the need for accurate segmentation methods to assist clinicians in their management. In this paper, we present a novel approa...
Jessie Lee,Peter S Giannaris,Cigdem Erkuran Yilmaz et al.
Jessie Lee et al.
Ischemic stroke is a devastating global public health problem and the leading cause of acute death and chronic disability. Despite being the diagnostic cornerstone, limitations in neuroimaging, including availability, cost, and therapeutic ...
The biomechanics and prevention of vein graft failure in coronary revascularization [0.03%]
冠状动脉血管重建时的植皮生物力学及其防护措施
Elbert E Heng,Hanjay Wang,Oluwatomisin Obafemi et al.
Elbert E Heng et al.
Saphenous vein grafts (SVGs) are the most widely used conduit in coronary artery bypass grafting (CABG) surgery; however, SVG failures due to neointimal hyperplasia present a significant long-term limitation to the effectiveness of myocardi...
The heart team: the multidisciplinary approach to coronary artery disease [0.03%]
冠心病的多学科方法：“心脏团队”的作用
Ramon A Riojas,Jennifer S Lawton,Thomas S Metkus Jr
Ramon A Riojas
The recommendation to employ a heart team to guide revascularization has persisted for over a decade. Despite evidence for improved adherence to guidelines, widespread adoption of the heart team approach has been limited. This review delves...
Comparative effects of canagliflozin and sitagliptin in chronically ischemic myocardium [0.03%]
卡格列净与西他列汀对慢性心肌缺血影响的比较研究
Sharif A Sabe,Dwight D Harris,Mark Broadwin et al.
Sharif A Sabe et al.
Aim: Recent studies demonstrate that sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase-4 inhibitors (DPP4i), two classes of antidiabetic drugs, are cardioprotective. However, the mechanisms of th...
Lack of cardiac benefit after intramyocardial or intravenous injection of mesenchymal stem cell-derived extracellular vesicles supports the need for optimized cardiac delivery [0.03%]
心内或静脉注射间充质干细胞来源的细胞外囊泡缺乏心脏益处，支持了优化心脏递送的必要性
Cynthia M Xu,Mark Broadwin,Patrick Faherty et al.
Cynthia M Xu et al.
Aim: To determine the differences in improvement in cardiac function by intramyocardial (IM) vs. intravenous (IV) injection of human bone mesenchymal stem cell-derived extracellular vesicles (HBMSC-EV) after acute MI. ...
Cardiac blood vessels and irreversible electroporation: findings from pulsed field ablation [0.03%]
心脏血管与不可逆电穿孔：脉冲电场消融的发现
Ikeotunye Royal Chinyere,Shumpei Mori,Mathew D Hutchinson
Ikeotunye Royal Chinyere
The clinical use of irreversible electroporation in invasive cardiac laboratories, termed pulsed field ablation (PFA), is gaining early enthusiasm among electrophysiologists for the management of both atrial and ventricular arrhythmogenic s...
Sophie Maiocchi,Elizabeth N Collins,Andrew R Peterson et al.
Sophie Maiocchi et al.
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate translation and are involved in many pathological processes. They have emerged as promising biomarkers for diagnosis of conditions such as aortic aneurysm disease. Quantify...
Extracellular vesicle treatment partially reverts epigenetic alterations in chronically ischemic porcine myocardium [0.03%]
外泌体治疗可部分逆转慢性心肌缺血的表观遗传学改变
Mark Broadwin,Ghazal Aghagoli,Sharif A Sabe et al.
Mark Broadwin et al.
Introduction: Research has shown epigenetic change via alternation of the methylation profile of human skeletal muscle DNA after Cardio-Pulmonary Bypass (CPB). In this study, we investigated the change in epigenome-wide D...