Signaling Centers Drive Brachyury Dynamics and Lineage Commitment in mESC Aggregates [0.03%]
;brachyury动力学和小鼠胚胎干细胞聚集体中谱系决定受信号中心驱动
A Rabeling,M Goolam
A Rabeling
Stem cell-based models of embryogenesis have exploded in popularity, resulting in protocols with overlapping use of some reagents and differential use of others. As such, the precise contributions of individual signaling molecules, such as ...
Effects of Bone Morphogenetic Protein-7 on Steroid-Induced Extracellular Matrix Accumulation in Human Trabecular Meshwork Cells [0.03%]
骨形态生成蛋白-7对糖皮质激素诱导人小梁网细胞外基质积累的影响
Eun Woo Kim,Jin-Ok Choi,Min Kyung Chae et al.
Eun Woo Kim et al.
Long-term steroid use, though essential for treating eye diseases, can cause increased intraocular pressure (IOP) in susceptible individuals and may lead to steroid-induced glaucoma in a subset of patients. This study investigated the effec...
The SUV39 Family of H3K9 Methyltransferases in Skeletal Muscle Stem Cells [0.03%]
SUV39家族H3K9甲基转移酶在骨骼肌干细胞中的作用
Pauline Garcia,Slimane Ait-Si-Ali,Fabien Le Grand
Pauline Garcia
Skeletal muscle repair is primarily driven by muscle stem cells (MuSCs) that regenerate damaged myofibers. The differentiation process of MuSCs into differentiated myofibers, known as adult myogenesis, is tightly regulated by various transc...
COMMD10 Regulates Angiogenesis and Bone Formation via Rap1 Signaling Pathway [0.03%]
COMMD10通过Rap1信号通路调控血管生成和骨形成
Peiran Li,Yanxi Li
Peiran Li
Copper metabolism MURR1 domain protein 10 (COMMD10) regulates numerous biological processes that are essential for cellular homeostasis. However, the role of COMMD10 in angiogenesis and bone formation remains unexplored. We constructed a CO...
NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27-Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss [0.03%]
NPC1L1通过激活C/EBPα/Cyp27a1/27-羟基胆固醇轴驱动骨质疏松症：治疗骨丢失的新靶点
Bohao Li,Wuling Zhou,Yueming Yu et al.
Bohao Li et al.
This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function. We also explored the role of NPC1L1 in osteoporosis (OP), focusing o...
Obesity Alters the Vascular Morphology and VEGF-A Signaling in Adipose Tissue [0.03%]
肥胖改变脂肪组织血管形态和VEGF-A信号转导
Yunjeong Lee,Keith Lionel Tukei,Yingye Fang et al.
Yunjeong Lee et al.
Obesity is a global health crisis, with its prevalence particularly severe in the United States, where over 42% of adults live with obesity. Obesity is driven by complex molecular and tissue-level mechanisms that remain poorly understood. A...
Netrin-4 Modulates Corneal Wound Healing by Enhancing Corneal Epithelium and Nerve Regeneration [0.03%]
Netrin-4通过促进角膜上皮和神经再生调节角膜伤口愈合
Cissy Xiao,Daniel Lara-Newman,Qiang Zhou et al.
Cissy Xiao et al.
Axon guidance proteins have been found to play a regenerative role in the peripheral nervous system and the cornea. Netrin-4 is a member of the Netrins family of axon guidance proteins implicated in diabetic retinopathy and corneal hemangio...
Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age-Related Macular Degeneration [0.03%]
评估超氧化物歧化酶治疗湿性年龄相关性黄斑变生成年大鼠模型的潜力
Hyun Chul Jeong,Chang Sik Cho,Jeong Hyun Kim et al.
Hyun Chul Jeong et al.
Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly, with limited oral treatment options for the wet form characterized by choroidal neovascularization (CNV). This study evaluated GF103, a mutant superoxide...
Induction of Peroxisomal β-Oxidation as a Critical Mechanism for Ethanol-Induced Hepatic Triglyceride Accumulation [0.03%]
乙醇通过诱导过氧化物酶体β氧化作为关键机制导致肝内三酰甘油聚集
Yida Zhang,Wei Zhang,Yicong Li et al.
Yida Zhang et al.
Excessive oxidation of ethanol has been well known to induce hepatic triglyceride accumulation, while the underlying pathogenic mechanisms are not fully demonstrated. The peroxisomal catalase-hydrogen peroxide complex system plays a role in...
Phenotypic Shifts in Macrophages Within Advanced Atherosclerotic Plaques in Humans [0.03%]
人类动脉粥样硬化斑块中巨噬细胞的表型变化
Barbora Muffova,Sona Kauerova,Hana Bartuskova et al.
Barbora Muffova et al.
The importance of macrophage polarization through atherogenesis is established. However, most studies rely on immunohistological approaches, which have several limitations, such as precluding comprehensive phenotypic analysis. The aim of th...