Ye Liu,H Josh Jang,Tao Yang
Ye Liu
Retrotransposons, including non-LTR elements such as LINEs and viral-derived endogenous retroviruses (ERVs), have long been dismissed as "junk DNA" and thought to be biochemically inert. However, emerging evidence suggests that the erosion ...
Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer [0.03%]
胰腺癌预后预测的RNA m6A/m1A/m5C/m7G/ψ调控因子之间的相互作用
Shiyin Chen,Jiawei Mao,Lin Xu et al.
Shiyin Chen et al.
N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), and pseudouridine (ψ) have been identified as the most prevalent epitranscriptomic modifications on eukaryotic RNAs. It is not yet clear a...
Synaptic Inhibition in the Accessory Olfactory Bulb Regulates Pheromone Location Learning and Memory [0.03%]
副嗅球突触抑制调节信息素定位学习和记忆
Shruti D Marathe,Sanyukta Pandey,Devesh Rawat et al.
Shruti D Marathe et al.
Pheromone signaling is pivotal in driving the social and reproductive behaviors of rodents. Learning and memorizing the pheromone locations involve olfactory subsystems. To study the neural basis of this behavior, we trained female heterozy...
Enhancing the Therapeutic Profile of Dapagliflozin: Chitosan Nanoparticle Encapsulation for Intestinal Applications [0.03%]
壳聚糖纳米颗粒包封增强达格列净的治疗谱以用于肠粘膜给药
Agni Klonari,Antrea-Maria Athinodorou,Eirini Papanikolaou et al.
Agni Klonari et al.
Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor primarily used to treat type 2 diabetes by lowering blood glucose levels. In addition to its antidiabetic action, it has demonstrated cardioprotective and renoprotective e...
APOE4 Drives Sex- and Diet-Dependent Effects on AD-Like Pathology, Cognition, and Mitochondrial Function [0.03%]
载脂蛋白E4通过性别和饮食依赖性驱动阿尔茨海默病样病理、认知和线粒体功能异常
Chelsea N Johnson,Colton R Lysaker,Xin Cao et al.
Chelsea N Johnson et al.
Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele promotes disease. While factors like diet and sex may modify AD susceptibility in APOE4 carriers, the interaction ...
MicroRNA 15a and 16 Regulate Proteostasis in Non-Small Cell Lung Cancer [0.03%]
microRNA 15a和16通过调节非小细胞肺癌中的蛋白质稳态发挥肿瘤抑制作用
Patrick J Ryan,Bethany C Guerra,Peter Nghiem et al.
Patrick J Ryan et al.
Aberrant anabolic activity is critical to tumor biology; however, much remains to be learned about the regulators of protein anabolism in cancer and how this regulation may affect cancer pathophysiology. MicroRNA (miRNA), a family of small ...
Network Analysis Identifies Microsomal Glutathione S-Transferase as a Potential Regulator of Oxidative Stress and Proteasome Dysfunction in Human Osteoarthritic Menisci [0.03%]
网络分析识别出微粒体谷胱甘肽转移酶是人类骨关节炎半月板氧化应激和蛋白酶体功能障碍的潜在调节因子
Xinjie Wu,Amina Hamzatova,Cecilia Aulin et al.
Xinjie Wu et al.
Osteoarthritis (OA)-related meniscal degeneration involves complex interactions between oxidative stress and proteasomal dysfunction. However, the molecular drivers of regional meniscal vulnerability remain poorly defined. This study integr...
Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes-A Cautionary Tale [0.03%]
BMPR1A在下丘脑室管膜细胞消融中的方法学挑战——一则警示故事
Tianyi Tao,Noelle Leon-Palmer,Sabrina DiPietro et al.
Tianyi Tao et al.
The hypothalamus coordinates energy-balance regulation and is also a neurogenic/plastic region in the adult brain. Tanycytes, a specialized population of radial glial-like cells lining the third ventricle, reside at the critical interface b...
The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal Myotubes [0.03%]
棕榈乙醇胺或布洛芬对C2C12骨骼肌管蛋白质丰度谱和合成速率的影响
Paige L Cole,Connor A Stead,Jatin G Burniston et al.
Paige L Cole et al.
Palmitoylethanolamide (PEA) and ibuprofen (IBU) exert anti-inflammatory effects that may influence skeletal muscle adaptation; however, their impact on muscle proteome dynamics remains unclear. Dynamic proteome profiling was performed in di...
Serum Proteomics of Multiple Menstrual Symptoms in Female Athletes: A Pilot Study [0.03%]
运动员多月经症状的血清蛋白质组学研究：一项初步研究
Kai Fushimi,Tasuku Kondo,Nodoka Ikegami et al.
Kai Fushimi et al.
Menstrual symptoms, including primary dysmenorrhea and premenstrual syndrome, are significant problems affecting women's health condition. However, their biological functions are still unclear. The objective of this study was to elucidate p...