Matrix Stiffness Regulates TGFβ1-Induced αSMA Expression via a G9a-LATS-YAP Signaling Cascade [0.03%]
基质 stiffness 通过 G9a-LATS-YAP 信号轴调控 TGFβ1 诱导的 αSMA 表达
Chinmay S Sankhe,Jessica L Sacco,Victoria L Crunkleton et al.
Chinmay S Sankhe et al.
Extracellular matrix stiffness is enhanced in cancer and fibrosis; however, there is limited knowledge on how matrix mechanics modulate expression and signaling of the methyltransferase G9a. Here, we show that matrix stiffness and transform...
Irisin Prevents the Effects of Simulated Microgravity on Bone and Muscle Differentiation Markers [0.03%]
irisin对模拟微重力引起的骨肌分化标记物的影响作用
Lorenzo Sanesi,Roberta Zerlotin,Alessio Campiolo et al.
Lorenzo Sanesi et al.
Microgravity exposure affects both tissues and cells, and, in this regard, one of the most affected targets is the skeletal muscle system due to the significant loss of bone and muscle mass leading to osteoporosis and sarcopenia, respective...
PICRUSt2 Analysis of Fecal Microbiome Associated With a Murine Model of Multiple Sclerosis [0.03%]
基于多发性硬化小鼠模型的粪便菌群的PICRUSt2分析
Sean M Schumacher,William J Doyle,Kristina Hill et al.
Sean M Schumacher et al.
Multiple sclerosis (MS) is a debilitating neuroinflammatory disease of the central nervous system (CNS). Approximately 2-3 million people globally are believed to have MS. There is growing interest in the mechanistic link between MS and gut...
Circulating Inflammatory Proteins Mediate the Causal Effect of Gut Microbiota on Inflammatory Bowel Disease: Bayesian and Mediated Mendelian Randomization [0.03%]
基于贝叶斯和中介性孟德尔随机化的循环炎症蛋白介导了肠道微生物群对炎症性肠病的因果效应
Zeyang Li,Lei Jia,Shengnan Huai
Zeyang Li
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), presents a global public health challenge. Although the relationships between gut microbiota, inflammatory proteins, and IBD are recognized, their...
Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study [0.03%]
木材烟雾对凝血无影响：一项初步的受控暴露研究
Dre&#x; Von A Dobson,Lori A Holle,Kohei Tatsumi et al.
Dre&#x; Von A Dobson et al.
Inhalation of wood smoke (WS) has been associated with increased risk of cardiovascular events, including heart attacks and strokes, both of which are caused in part by the thrombotic occlusion of blood vessels. To characterize the effects ...
Single-Cell Analysis of Alternative Splicing and Gene Regulatory Network Reveals Remarkable Expression and Regulation Dynamics During Human Early Embryonic Development [0.03%]
单细胞分析揭示人类早期胚胎发育过程中选择性拼接和基因调控网络的动态变化
Jiwei Chen,Gaigai Wei,Fangge Sun et al.
Jiwei Chen et al.
Single-cell RNA-seq (scRNA-seq) technologies greatly revolutionized our understanding of cell-to-cell variability of gene expression, but few scRNA-seq technologies were used to describe the expression dynamics at the isoform and exon level...
Endoplasmic Reticulum Stress and Unfolded Protein Response Sensor ERN1 Regulates Organic Dust Induction of Lung Inflammation [0.03%]
内质网胁迫和未折叠蛋白反应传感器ERN1调控有机粉尘诱导的肺部炎症反应
Shilpa Kusampudi,Velmurugan Meganathan,Vijay Boggaram
Shilpa Kusampudi
Inhalation of organic dust increases the risk for respiratory symptoms and respiratory diseases, with chronic inflammation playing a major role in their development. Previously, we reported that organic dust induction of inflammatory mediat...
Prognostic Value of TBC1D1 and Its Relationship With the Tumor Microenvironment in Pancreatic Cancer: A Study Based on Single-Cell Sequencing [0.03%]
TBC1D1的预后价值及其与胰腺癌肿瘤微环境的关系：基于单细胞测序的研究
Linfeng Yang,Duan Yan,Jun Yu et al.
Linfeng Yang et al.
TBC1 Domain Family Member 1 (TBC1D1) plays a crucial role in various cancers. However, its specific function in pancreatic cancer (PC) remains poorly understood. In this study, we aimed to evaluate the prognostic value of TBC1D1 and its cor...
PINK1 Loss of Function Selectively Alters the Mitochondrial-Derived Vesicle Pathway [0.03%]
PINK1功能丧失选择性地改变线粒体衍生囊泡途径
Charlotte L Collier,Colleen Ruedi,Naomi J Thorne et al.
Charlotte L Collier et al.
Cell homeostasis and metabolic control require the efficient function of mitochondria and implementation of quality control pathways following damage. Cells have various discrete pathways of mitochondrial quality control (mitoQC) to maintai...
Caryn T Morgan,Sanah M Nkadimeng
Caryn T Morgan
Migraine is a chronic pulsating primary headache affecting billions of individuals worldwide. The condition is associated with neuroinflammation and is listed as the second most common form of headache disorders and the leading cause of dis...