Peiran Li,Yanxi Li,Xuejiu Wang et al.
Peiran Li et al.
Previous studies reported the pro-osteogenic ability of L-Tryptophan (L-Trp) and Calcium-Sensing RCeceptor (CaSR) respectively. Recent researchers found L-Trp could activate CaSR. Therefore, this study investigated the osteogenic mechanisms...
Beyond the Gut: Unveiling Methane's Role in Broader Physiological Systems [0.03%]
超越肠道：揭开甲烷在更广泛生理系统中的作用
Matthew Kerr,Madeleine Ball,Nabeetha Nagalingam et al.
Matthew Kerr et al.
Interest in the endogenous role of methane has grown rapidly over the past decade, driven both by its relevance for disease detection (including intestinal methanogen overgrowth) as well as discoveries that raise the possibility of endogeno...
Oral MIB-626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID-19 and Acute Kidney Injury: A Randomized Controlled Trial [0.03%]
MIB-626（β烟胺单核苷酸）口服安全提高COVID-19和急性肾损伤住院患者的血清烟酰胺腺嘌呤二核苷酸水平：一项随机对照试验
Karol M Pencina,David E Leaf,Rodrigo J Valderrabano et al.
Karol M Pencina et al.
Nicotinamide adenine dinucleotide (NAD+) plays an important role in the innate immune response and is depleted during SARS-CoV-2 infection due to increased turnover. It is unknown whether treatment with NAD+ precursors can safely raise NAD+...
Role of NRP1/HDAC4/CREB/RIPK1 Axis in SARS-CoV2 S1 Spike Subunit-Induced Neuronal Toxicity [0.03%]
NRP1/HDAC4/CREB/RIPK1轴在SARS-CoV-2 S1刺突亚单位诱导的神经毒性中的作用
Luca Sanguigno,Natascia Guida,Mariarosaria Cammarota et al.
Luca Sanguigno et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is associated with neurological symptoms, but the molecular mechanisms have not yet been identified. Since the S1 subunit (S1) of the envelope of the SARS-CoV2 Spike glycoprotein c...
Plasmalogen as a Bioactive Lipid Drug: From Preclinical Research Challenges to Opportunities in Nanomedicine [0.03%]
半乳糖基醇作为生物活性脂质药物：从纳米医学的药理研究挑战到机遇
Yu Wu,Yuru Deng,Borislav Angelov et al.
Yu Wu et al.
Plasmalogens are natural glycerophospholipids that account for approximately 15%-20% (mol%) of human tissues' cellular membrane phospholipid composition. They play an important role in lipid membrane organization and function, including act...
The Hill-Type Equation Reveals the Regulatory Principle of Target Protein Expression Led by p53 Pulsing [0.03%]
Hill型方程揭示p53脉冲诱导靶蛋白表达的调控规律
Xiaomin Shi
Xiaomin Shi
The central dogma indicates the basic direction of gene expression pathways. For activated gene expression, the quantitative relationship between various links from the binding of transcription factors (TFs) to DNA to protein synthesis rema...
Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle [0.03%]
急性耐力运动对骨骼肌可变剪接的影响
Alexander Ahn,Jeongjin J Kim,Aaron L Slusher et al.
Alexander Ahn et al.
Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome. Acute endurance exercise appears to transiently perturb AS in skeletal muscle, but transcriptome-wide respons...
Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction-Associated Steatotic Liver Disease in Perinatal Cadmium-Exposed Mice [0.03%]
孕期补铁通过改善生长发育和代谢表型减轻镉暴露诱导的新生小鼠非酒精性脂肪肝病（NALFD)
Rebecca Lichtler,Hannah Klossner,Nikia Smith et al.
Rebecca Lichtler et al.
Iron (Fe)-deficiency (ID) and Fe-deficiency anemia (IDA) are highly prevalent conditions and are of particular concern to maternal-child health. ID and IDA are typically linked to nutritional deficiencies, but maternal exposure to heavy met...
A Common Mutation in the Homeostatic Iron Regulatory Gene Alters Astrocyte Migration and Redox Profile [0.03%]
铁稳态调节基因的常见突变会影响星形胶质细胞的迁移和氧化还原状态
Makenzie Nolt,Elizabeth Neely,Sina Kheirabadi et al.
Makenzie Nolt et al.
Astrocytes play a vital role in maintaining homeostasis and function in the central nervous system, including their involvement in reparative processes. Here, we examined how a common mutation in the homeostatic iron regulatory gene, H67D H...
Single-Cell RNA Sequencing Reveals the Critical Role of SEC16B in Lung Metastasis of Osteosarcoma [0.03%]
单细胞RNA测序揭示SEC16B在骨肉瘤肺转移中的关键作用
Shangyu Liu,Haijun Tang,Shanhang Li et al.
Shangyu Liu et al.
Osteosarcoma (OS) is highly malignant and easily prone to lung metastasis. The mechanisms of lung metastasis in OS remain unclear. The single-cell RNA sequencing (scRNA-seq) samples in this study included six primary osteosarcoma samples (p...