Cyanidin-3-Glucoside Supplementation Modulates Bone Resorption in Experimental Apical Periodontitis [0.03%]
花青素-3-半乳糖苷对根尖周炎骨吸收的调节作用
Rafaela Ricci,Romulo de Oliveira Sales-Junior,Maria Antônia Leonardo Pereira Neta et al.
Rafaela Ricci et al.
Apical periodontitis (AP) is an inflammatory/infectious disease that leads to alveolar bone resorption. Cyanidin-3-glucoside (C3G) is an anthocyanin known for its anti-inflammatory, antioxidant, and bone metabolism-regulating properties, su...
Xiaoxianxiong Decoction Attenuates LPS-Induced Pneumonia in Mice by Inhibiting Inflammatory Response Through Activation of SIRT1 [0.03%]
小陷胸汤通过激活SIRT1抑制炎症反应缓解脂多糖诱导的小鼠肺炎
Linfeng Shi,Jiayan Zhang,Yuntao Cai et al.
Linfeng Shi et al.
Xiaoxianxiong decoction (XXXD) is a widely used clinical prescription effective in the treatment of pneumonia. The study investigates the efficacy and mechanism of XXXD in pneumonia. In the study, an in vivo pneumonia model was induced by l...
Targeting High-Density Aromatic Peptides to Cardiolipin Optimizes the Mitochondrial Membrane Potential and Inhibits Oxidative Stress [0.03%]
针对辅酶Q偶联的线粒体氧化磷酸化复合体聚集的芳香多肽优化线粒体膜电位及抑制氧化应激作用
Alexander Birk,Sara Arain,Daniele Musumeci et al.
Alexander Birk et al.
Cardiolipin (CL), a mitochondria-specific non-bilayer phospholipid, plays an essential role in the assembly and structural dynamics of the respiratory chain, affecting the membrane morphology and functional activity of inner mitochondria me...
RIP1 Contributes to Colorectal Cancer Progression and Lymphatic Remodeling in Association With VEGF-C/NF-κB Pathway [0.03%]
RIP1通过VEGF-C/NF-κB通路参与结直肠癌进展及淋巴重建
Maolin Li,Humin Li
Maolin Li
Receptor-interacting protein kinase 1 (RIP1) plays a regulatory role in inflammation and cell survival, but its involvement in colorectal cancer (CRC), particularly in relation to lymphatic changes within the tumor microenvironment, remains...
GCN5L1 Inhibits Pyruvate Dehydrogenase Phosphorylation During Cardiac Ischemia-Reperfusion Injury [0.03%]
GCN5L1在心脏缺血再灌注损伤中通过抑制丙酮酸脱氢酶磷酸化发挥保护作用
Paramesha Bugga,Michael W Stoner,Janet R Manning et al.
Paramesha Bugga et al.
Myocardial infarction remains one of the leading causes of mortality. Reperfusion of the infarcted myocardium restores blood flow and reduces primary ischemic injury. However, despite its protective function, reperfusion is also associated ...
Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity [0.03%]
内皮细胞膜相关蛋白MEMO1在早产儿视网膜病变模型中的血管生成信号调节作用
Aniket Ramshekar,Bright Asare-Bediako,Jasmine Nguyen et al.
Aniket Ramshekar et al.
Vascular endothelial growth factor (VEGF) is important in both developmental and pathologic angiogenesis in retinopathy of prematurity (ROP). Using a rat model representative of ROP, we found that regulation of VEGF signaling through VEGF r...
Monoclonal Antibody 5F1 Modulates Formyl Peptide Receptor 1 Conformation for Transmembrane Signaling [0.03%]
单克隆抗体5F1通过调节肽酰基受体1构象来传递跨膜信号
Yue Wang,Yezhou Liu,Yixin Chang et al.
Yue Wang et al.
Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full-length FPR1 and used widely for detection of F...
Transamniotic Delivery of Coagulation Factor VIII mRNA: A Step Toward a Potential Novel Strategy for the Perinatal Management of Hemophilia A [0.03%]
宫内递送血友病A基因治疗载体及相关凝血因子VIII mRNA的检测指标及意义：迈向新生儿血友病A基因治疗的第一步
Kamila Moskowitzova,Emily M Scire,Tanya T Dang et al.
Kamila Moskowitzova et al.
Hemophilia A is an X-linked monogenic disease resulting in insufficient pro-coagulant factor VIII (FVIII) levels. Hemophiliac infants are at risk for life-threatening hemorrhage, especially during birth. No perinatal treatment for Hemophili...
Unraveling the Vicious Cycle: Oxidative Stress and Neurotoxicity in Neurodegenerative Diseases [0.03%]
破解恶性循环：神经退行性疾病中的氧化应激与神经毒性
Xuezi Wang,Baolin Dong,Qi Gan et al.
Xuezi Wang et al.
Oxidative stress is characterized by an imbalance between the production and elimination of free radicals, where the rate of free radical generation surpasses the rate of their removal. This imbalance can lead to tissue and organ damage, co...
Rescue of the Stargardt Disease Phenotype in Abca4 Knockout Mice Through Dietary Modulation of the Vitamin A Receptor RBPR2 [0.03%]
通过饮食调节维生素A受体RBPR2挽救ABCA4敲除小鼠的Stargardt疾病表型
Rakesh Radhakrishnan,Matthias Leung,Drew Yochim et al.
Rakesh Radhakrishnan et al.
Mutations in the ABCA4 gene in Stargardt disease (STGD1) cause enhanced accumulation of cytotoxic lipofuscin, manifesting in RPE atrophy and photoreceptor dysfunction. One component of lipofuscin is the all-trans-retinal derivative, pyridin...