Ellagic Acid and Its Nanoparticles Mitigate Atherosclerosis by Elevating Low-Density Lipoprotein Receptor Levels Through Targeting of the Epidermal Growth Factor Receptor [0.03%]
通过靶向表皮生长因子受体提高低密度脂蛋白受体水平以缓解动脉粥样硬化：杨梅素及其纳米粒的作用
Guo-Tao Li,Li-Tian Wang,Huai-Liu Yin et al.
Guo-Tao Li et al.
Atherosclerosis is a chronic vascular disease characterized by the accumulation of cholesterol-rich lipids within the intima of large and medium-sized arteries. It is a leading cause of morbidity and mortality worldwide, contributing to the...
Ethan Pei,Junfeng Ma
Ethan Pei
De novo proline synthesis is a highly conserved and essential biochemical pathway in mammals. Beyond serving as a fundamental building block for proteins, proline also plays key roles in diverse cellular functions and maintaining tissue hom...
Impact of Type 1 Diabetes on Endothelial Cells Derived From Living Donors [0.03%]
1型糖尿病对活体供者来源的内皮细胞的影响
Isra Marei,Maria Vinokurova,Li Qiucheng et al.
Isra Marei et al.
Endothelial colony forming cells (ECFCs) derived from peripheral blood have been shown to retain disease phenotype in several conditions thus possessing great translational potential for regenerative medicine. Hyperglycaemia may alter the p...
Advances in Induced Pluripotent Stem Cell Reprogramming and Its Application in Amyotrophic Lateral Sclerosis: A Review [0.03%]
诱导多能干细胞重编程的进展及其在肌萎缩侧索硬化症中的应用：综述
Yingliu Luo,Zhenru Xu,Zunxiong Li
Yingliu Luo
Since Yamanaka's landmark achievement in reprogramming somatic cells into induced pluripotent stem cells (iPSCs) using the four key transcription factors-OCT4, SOX2, KLF4, and c-Myc (OSKM)-iPSC technology has made significant strides. Notab...
Mechanisms of Pilocarpine-Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle [0.03%]
毛果芸香碱诱导猪睫状肌一氧化氮和前列腺素产生的机制研究
Giovanna Benozzi,Emmanuel Quinteros Villarruel,Andrés F Zuluaga et al.
Giovanna Benozzi et al.
Pilocarpine, a muscarinic receptor agonist, is clinically used to reduce intraocular pressure via ciliary muscle contraction. However, the intracellular signaling pathways mediating pilocarpine-induced nitric oxide (NO) and prostaglandin E2...
Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High-Fat Diet [0.03%]
叶酸通过增强胆碱的可用性和重塑脂肪酸谱减轻高脂饮食小鼠的肝脏脂质蓄积
Eva Kranenburg,Ruslan Kubant,Zeyu Yang et al.
Eva Kranenburg et al.
High-fat diets (HFDs) are a well-established cause of hepatic steatosis, a condition associated with altered hepatic fatty acid metabolism and reduced choline availability. Folic acid (FA) deficiency can also promote steatosis, in part by i...
LPAR1 Promotes Activation of Pathways Alveolar Hypercoagulation and Fibrinolytic Inhibition in ARDS via NF-κB Signaling Pathway [0.03%]
LPAR1通过NF-κB信号途径促进急性呼吸窘迫综合征肺泡高凝和纤溶抑制激活
Ying Liu,Xianjun Chen,Meng Liu et al.
Ying Liu et al.
Alveolar hypercoagulation and fibrinolytic inhibition are critical mechanisms contributing to refractory hypoxemia in acute respiratory distress syndrome (ARDS). The nuclear factor kappa-B (NF-κB) pathway is known to play a role in these p...
Influence of Acute Phase Proteins on Neutrophil Function In Vitro [0.03%]
急性期蛋白对 neutrophil 体外功能的影响研究
Richard F Kraus,Isabell Wild,Michael A Gruber et al.
Richard F Kraus et al.
As part of a systemic inflammatory response, acute phase proteins (APPs) are released into the blood to support the body's immune response. Once in the bloodstream, the APPs can also interact with immune cells, such as neutrophil granulocyt...
Adipocyte Calpain-2 Deficiency Reduces Obesity-Accelerated Abdominal Aortic Aneurysm Formation in Mice [0.03%]
小鼠脂肪细胞钙蛋白-2缺乏可减少肥胖加速的腹主动脉瘤形成
Ana Clara Frony,Aida Javidan,Weihua Jiang et al.
Ana Clara Frony et al.
Abdominal adiposity is associated with increased risk of abdominal aortic aneurysm (AAA) development. Calpains are non-lysosomal calcium-dependent cysteine proteases that are highly expressed in human and experimental AAAs. Using a pharmaco...
Calumenin, A Calcium-Binding Modulatory Protein, Effective in Pathological Calcifications and Cancers, With Therapeutic Application Promise [0.03%]
一种新的钙结合调节蛋白Calumenin在病理钙化和肿瘤中起作用及潜在的治疗价值
Parinaz Nasri Nasrabadi,Babak Jahangiri,Zahra Amiri et al.
Parinaz Nasri Nasrabadi et al.
Calumenin (CALU), a multifunctional E-F-hand protein of the CREC family involved in various cellular processes, is ubiquitously expressed in almost all human tissues, although its expression level is tissue-specific. CALU plays an effective...