1,25(OH)2D3 regulates the proangiogenic activity of pericyte through VDR-mediated modulation of VEGF production and signaling of VEGF and PDGF receptors [0.03%]
1,25-二羟基维生素D3通过VDR介导的VEGF产生和VEGF及PDGF受体信号调节周细胞促血管生成活性
Nasim Jamali,Yong-Seok Song,Christine M Sorenson et al.
Nasim Jamali et al.
We have previously demonstrated that the active form of vitamin D (calcitriol; 1,25(OH)2D3) is a potent inhibitor of retinal neovascularization. However, the underlying molecular and cellular mechanisms involved remained poorly understood. ...
Inhibition of osteoclastogenesis by opsonized Porphyromonas gingivalis [0.03%]
包膜的牙龈卟啉单胞菌对破骨细胞生成的抑制作用
Subramanya N Pandruvada,Jeffrey L Ebersole,Sarandeep S Huja
Subramanya N Pandruvada
A crucial step in the pathogenesis of periodontal disease (PD) is activation of osteoclasts (OC) by numerous virulence factors produced by Porphyromonas gingivalis (Pg). To understand pathogenesis of periodontal disease and the role of spec...
Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning [0.03%]
六氯铂酸肌内注射可逆转氰化物所致的代谢紊乱并对抗严重氰化物中毒
Jordan Morningstar,Jangwoen Lee,Tara Hendry-Hofer et al.
Jordan Morningstar et al.
Cyanide is a highly toxic industrial chemical that is widely used by manufactures. Smoke inhalation during household fires is the most common source of cyanide poisoning while additional risks to civilians include industrial accidents and t...
Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion [0.03%]
结构决定因素和遗传修饰增强BMP2稳定性和细胞外分泌
Vinayak Khattar,Joo Hyoung Lee,Hong Wang et al.
Vinayak Khattar et al.
The short half-life and use of recombinant bone morphogenetic protein (BMP)-2 in large doses poses major limitations in the clinic. Events regulating post-translational processing and degradation of BMP2 in situ, linked to its secretion, ha...
Protease-activated receptor 2 activates CRAC-mediated Ca2+ influx to cause prostate smooth muscle contraction [0.03%]
蛋白酶激活受体2通过活化CRAC介导的钙离子内流引起前列腺平滑肌收缩
Madhumita Paul,Stephen F Murphy,Christel Hall et al.
Madhumita Paul et al.
Protease activated receptor 2 (PAR2) is a G-protein coupled receptor that contributes to prostate fibrosis and lower urinary tract symptoms (LUTS). In addition to fibrosis, aberrant smooth muscle tone in the prostate has been hypothesized t...
TRPC1 expression and function inhibit ER stress and cell death in salivary gland cells [0.03%]
瞬时受体电位阳离子通道A1通过抑制内质网应激改善舍格伦综合征模型中小唾液腺功能损伤
Pramod Sukumaran,Yuyang Sun,Fredice Quenum Zangbede et al.
Pramod Sukumaran et al.
Disturbances in endoplasmic reticulum (ER) Ca2+ homeostasis have been associated with many diseases including loss of salivary glands. Although significant progress has been accomplished which led to the increase in our understanding of the...
Chronic alcohol consumption exacerbates murine cytomegalovirus infection via impairing nonspecific and specific NK activation in mice [0.03%]
慢性酒精摄入通过损害小鼠的非特异性和特异性NK细胞活化加剧巨细胞病毒感染
Alex Little,Yuanfei Li,Faya Zhang et al.
Alex Little et al.
Chronic alcohol consumption increases the susceptibility to infectious diseases by compromising immune system. Cytomegalovirus infection is common in human and usually is asymptomatic in immunocompetent people. However, it can induce life-t...
Yes-associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss [0.03%]
YES相关蛋白促进肝组织损失后再生过程中早期肝细胞周期进展
Christoph Tschuor,Ekaterina Kachaylo,Udo Ungethüm et al.
Christoph Tschuor et al.
The ability of the liver to restore its original volume following tissue loss has been associated with the Hippo-YAP1 pathway, a key controller of organ size. Yes-associated protein 1 (YAP1)-a growth effector usually restrained by Hippo sig...
A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing [0.03%]
无需扩增和大规模多重PCR扩增的小鼠抗体库测序的比较分析
Trisha A Rettig,Michael J Pecaut,Stephen K Chapes
Trisha A Rettig
Sequencing antibody repertoires has steadily become cheaper and easier. Sequencing methods usually rely on some form of amplification, often a massively multiplexed PCR prior to sequencing. To eliminate potential biases and create a data se...