Chronic alcohol consumption exacerbates murine cytomegalovirus infection via impairing nonspecific and specific NK activation in mice [0.03%]
慢性酒精消耗通过损害小鼠的非特异性和特异性NK细胞活化加重小鼠巨细胞病毒的感染
Alex Little,Yuanfei Li,Faya Zhang et al.
Alex Little et al.
Chronic alcohol consumption increases the susceptibility to infectious diseases by compromising the immune system. Cytomegalovirus infection is common in humans and usually is asymptomatic in immunocompetent people. However, it can induce l...
A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing [0.03%]
无需扩增和大规模多重PCR扩增的小鼠抗体库测序对比研究
Trisha A Rettig,Michael J Pecaut,Stephen K Chapes
Trisha A Rettig
Sequencing antibody repertoires has steadily become cheaper and easier. Sequencing methods usually rely on some form of amplification, often a massively multiplexed PCR prior to sequencing. To eliminate potential biases and create a data se...
The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis [0.03%]
t(4;14)染色体重排的多发性骨髓瘤的snoRNA靶基因调控核糖体生物合成
Vanessa Oliveira,Nitin Mahajan,Melissa L Bates et al.
Vanessa Oliveira et al.
The orphan small nucleolar RNA (snoRNA) ACA11 is overexpressed as a result of the t(4;14) chromosomal translocation in multiple myeloma (MM), increases reactive oxygen species, and drives cell proliferation. Like other snoRNAs, ACA11 is pre...
Stimulation of Prostate Cells by the Senescence Phenotype of Epithelial and Stromal Cells: Implication for Benign Prostate Hyperplasia [0.03%]
上皮细胞和间质细胞衰老表型对前列腺细胞的刺激作用：良性前列腺增生的意义
Shoulei Jiang,Chung Seog Song,Bandana Chatterjee
Shoulei Jiang
Hyperproliferation of prostate transition-zone epithelial and stromal cells leads to benign prostate hyperplasia (BPH), a prevalent pathology in elderly men. Senescent cells in BPH tissue induce a senescence-associated secretory phenotype (...
Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function [0.03%]
podocyte GSK3α 对自噬很重要，其丢失对肾小球功能有害
J A Hurcombe,A C Lay,L Ni et al.
J A Hurcombe et al.
Podocytes are key cells in maintaining the integrity of the glomerular filtration barrier and preventing albuminuria. Glycogen synthase kinase 3 (GSK3) is a multi-functional serine/threonine kinase existing as two distinct but related isofo...
Dysregulated repair and inflammatory responses by e-cigarette-derived inhaled nicotine and humectant propylene glycol in a sex-dependent manner in mouse lung [0.03%]
以性二态方式气吸尼古丁和增湿剂丙二醇诱导的小鼠肺修复和炎症反应失调
Qixin Wang,Naushad Ahmad Khan,Thivanka Muthumalage et al.
Qixin Wang et al.
Nicotine inhalation via electronic cigarettes (e-cigs) is an emerging concern. However, little is known about the acute toxicity in the lungs following inhalation of nicotine-containing e-cig aerosols. We hypothesized that acute exposure to...
Lipidomic analysis of urinary exosomes from hereditary α-tryptasemia patients and healthy volunteers [0.03%]
遗传性α-胰蛋白酶血症患者和健康志愿者尿源性外泌体的脂质组分析
Sarah C Glover,Mohammad-Zaman Nouri,Kubra M Tuna et al.
Sarah C Glover et al.
Exosomes are nano-sized vesicles that are involved in various biological processes including cell differentiation, proliferation, signaling, and intercellular communication. Urinary exosomes were isolated from a cohort of hereditary α-tryp...
Insulin-like growth factor binding protein-4 exerts antifibrotic activity by reducing levels of connective tissue growth factor and the C-X-C chemokine receptor 4 [0.03%]
胰岛素样生长因子结合蛋白-4通过降低细胞外基质蛋白连接组织生长因子和C-X-C趋化因子受体4的表达水平发挥抗纤维化作用
YunYun Su,Tetsuya Nishimoto,Stanley Hoffman et al.
YunYun Su et al.
The Insulin-like growth factor (IGF) system plays an important role in variety cellular biological functions; we previously reported levels of IGF binding proteins (IGFBP) -3 and -5 are increased in dermal and pulmonary fibrosis associated ...
1,25(OH)2D3 regulates the proangiogenic activity of pericyte through VDR-mediated modulation of VEGF production and signaling of VEGF and PDGF receptors [0.03%]
1,25(OH)2D3通过维生素D受体介导调节血管内皮生长因子的产生和信号转导来调控周细胞的促血管生成活性
Nasim Jamali,Yong-Seok Song,Christine M Sorenson et al.
Nasim Jamali et al.
We have previously demonstrated that the active form of vitamin D (calcitriol; 1,25(OH)2D3) is a potent inhibitor of retinal neovascularization. However, the underlying molecular and cellular mechanisms involved remained poorly understood. ...