Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1 [0.03%]
Elovl1脂肪酸延长酶缺陷小鼠髓鞘神经节苷脂链长降低及运动协调能力受损
Masashi Isokawa,Takayuki Sassa,Satoko Hattori et al.
Masashi Isokawa et al.
Very-long-chain fatty acids, with a chain length of >C20, are abundant in myelin sphingolipids. Recently, a de novo mutation in the ELOVL1 gene, which encodes fatty acid elongase, was identified in patients with neurocutaneous disorders inv...
Regeneration competent satellite cell niches in rat engineered skeletal muscle [0.03%]
大鼠工程化骨骼肌中具备再生能力的卫星细胞生态位
Malte Tiburcy,Alex Markov,Lena K Kraemer et al.
Malte Tiburcy et al.
Satellite cells reside in defined niches and are activated upon skeletal muscle injury to facilitate regeneration. Mechanistic studies of skeletal muscle regeneration are hampered by the inability to faithfully simulate satellite cell biolo...
Identification of several plasma proteins whose levels in colorectal cancer patients differ depending on outcome [0.03%]
鉴定出几种在结直肠癌患者中的血浆蛋白水平差异取决于治疗效果蛋白质
Matilda Holm,Sakari Joenväärä,Mayank Saraswat et al.
Matilda Holm et al.
Colorectal cancer (CRC) stands for 10% of the worldwide cancer burden and has recently become the second most common cause of cancer death. The 5-year survival rate depends mainly on stage at diagnosis. Mass spectrometric proteomic analysis...
ECDI-fixed donor splenocytes prolong skin allograft survival by promoting M2 macrophage polarization and inducing regulatory T cells [0.03%]
固定供体脾细胞通过促进M2型巨噬细胞极化和诱导调节性T细胞来延长皮肤异体移植的存活率
Bo Zhou,Yuan Zhang,Dongliang Zhang et al.
Bo Zhou et al.
Rejection is a common complication of allogeneic tissue transplantation. Fixation of splenocytes (SP) with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) induces immune tolerance in recipients post-transplantation; however, the mech...
Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease [0.03%]
Bicaudal D1阻碍慢性阻塞性肺疾病中的自噬溶酶体成熟过程
Nicolas Mercado,Thomas Colley,Jonathan R Baker et al.
Nicolas Mercado et al.
Bicaudal D1 (BICD1), an adaptor for the dynein-dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD,...
Alpha-Klotho, a critical protein for lung health, is not expressed in normal lung [0.03%]
α-克洛托霍蛋白对肺健康至关重要但正常肺组织中不表达该蛋白
Jianning Zhang,Khoa Cao,Johanne V Pastor et al.
Jianning Zhang et al.
Alpha-Klotho (αKlotho), produced by the kidney and selected organs, is essential for tissue maintenance and protection. Homozygous αKlotho-deficiency leads to premature multi-organ degeneration and death; heterozygous insufficiency leads ...
Activity of lumacaftor is not conserved in zebrafish Cftr bearing the major cystic fibrosis-causing mutation [0.03%]
携有主要囊性纤维化致病突变的斑马鱼Cftr蛋白不具备lumacaftor药物作用活性
Onofrio Laselva,Steven Erwood,Kai Du et al.
Onofrio Laselva et al.
F508del-cystic fibrosis transmembrane conductance regulator (CFTR) is the major mutant responsible for cystic fibrosis (CF). ORKAMBI®, approved for patients bearing this mutant, contains lumacaftor (VX-809) that partially corrects F508del-...
Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo [0.03%]
银纳米颗粒选择性治疗三阴性乳腺癌细胞（无需影响非恶性乳腺上皮细胞）
Jessica Swanner,Cale D Fahrenholtz,Iliana Tenvooren et al.
Jessica Swanner et al.
Silver nanoparticles (AgNPs) show promise for treatment of aggressive cancers including triple-negative breast cancer (TNBC) in preclinical cancer models. For clinical development of AgNP-based therapeutics, it will be necessary to clearly ...
Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei [0.03%]
特定变体表面糖蛋白的表达对布氏锥虫硫磺素敏感性和内吞作用有重大影响
Natalie Wiedemar,Michaela Zwyer,Martin Zoltner et al.
Natalie Wiedemar et al.
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated through endocytosis and the suramin receptor i...
Using a Modified Lymphocyte Genome Sensitivity (LGS) test or TumorScan test to detect cancer at an early stage in each individual [0.03%]
使用改良的淋巴细胞基因组敏感性（LGS）试验或TumorScan试验对每位个体进行早期癌症检测
Diana Anderson,Mojgan Najafzadeh,Andrew Scally et al.
Diana Anderson et al.
Our previous case-control study observed isolated lymphocytes from 208 individuals and determined the differences in the sensitivity to genomic damage of lymphocytes derived from cancer patients, pre/suspect cancer patients and healthy volu...