Jean Personnaz,Enzo Piccolo,Maxime Branchereau et al.
Jean Personnaz et al.
Alarmins and damage-associated molecular patterns (DAMPs) are powerful inflammatory mediators, capable of initiating and maintaining sterile inflammation during acute or chronic tissue injury. Recent evidence suggests that alarmins/DAMPs ma...
In search of the altering salivary proteome in metastatic breast and ovarian cancers [0.03%]
寻找转移性乳腺癌和卵巢癌中改变的唾液蛋白组
Kuldeep Giri,Anurag Mehta,Kiran Ambatipudi
Kuldeep Giri
Breast and ovarian cancers, the most common cancers in women in India, are expected to rise in the next decade. Metastatic organotropism is a nonrandom, predetermined process which represents a more lethal and advanced form of cancer with i...
Calpain-mediated cleavage of p53 in human cytomegalovirus-infected lung fibroblasts [0.03%]
人巨细胞病毒感染的肺成纤维细胞中钙蛋白酶介导的p53切割现象
Zhenping Chen,Paul J Boor,Celeste C Finnerty et al.
Zhenping Chen et al.
Endogenous fragments of p53 protein were identified in human cytomegalovirus (HCMV)-infected human lung fibroblasts, particularly a 44-kDa N-terminal fragment [hereafter referred to as p53(ΔCp44)], generated via calpain cleavage. The fragm...
S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics [0.03%]
S-亚硝基化α1酸性糖蛋白对耐多药细菌具有抗菌活性并协同增强抗生素的疗效
Yu Ishima,Kaori Watanabe,Victor T G Chuang et al.
Yu Ishima et al.
Alpha-1-acid glycoprotein (AGP) is a major acute-phase protein. Biosynthesis of AGP increases markedly during inflammation and infection, similar to nitric oxide (NO) biosynthesis. AGP variant A (AGP) contains a reduced cysteine (Cys149). P...
Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues [0.03%]
干燥沙林，一种烟碱性乙酰胆碱受体拮抗剂，强调功能保守而非氨基酸残基结构保守的重要性
Ritu Chandna,Han-Shen Tae,Victoria A L Seymour et al.
Ritu Chandna et al.
Snake venom neurotoxins are potent antagonists of nicotinic acetylcholine receptors (nAChRs). Here, we describe a novel member of class 3c long-chain neurotoxin drysdalin from the venom of Drysdalia coronoides. Drysdalin lacks three of the ...
Tumor gene therapy by systemic delivery of plasmid DNA with cell-penetrating peptides [0.03%]
基于穿膜肽的质粒DNA全身给药用于肿瘤基因治疗
Kadri Künnapuu,Kadi-Liis Veiman,Ly Porosk et al.
Kadri Künnapuu et al.
Gene therapy is a prospective strategy for treating cancer. However, finding efficient and tumor-specific gene delivery vectors remains an issue. Tumor responsive cell-penetrating peptide (CPP) PepFect144 (PF144) has previously been shown t...
New technologies to introduce a catalytic function into antibodies: A unique human catalytic antibody light chain showing degradation of β-amyloid molecule along with the peptidase activity [0.03%]
引入抗体催化功能的新技术：一种独特的具有蛋白酶活性的人源催化型单克隆抗体轻链及其对β淀粉样蛋白的降解作用
Emi Hifumi,Hiroaki Taguchi,Eiichi Toorisaka et al.
Emi Hifumi et al.
Since the discovery of a natural catalytic antibody in 1989, many catalytic antibodies targeting peptides, nucleotides, virus and bacterial proteins, and many molecules have been prepared. Although catalytic antibodies should have features ...
High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction [0.03%]
STING的高表达通过介导III型干扰素诱导限制对HBV的易感性
Hiromichi Dansako,Hirotaka Imai,Youki Ueda et al.
Hiromichi Dansako et al.
Hepatitis B virus (HBV) is a hepatotropic DNA virus causing hepatic diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. To study HBV, human hepatoma HepG2 cells are currently used as an HBV infectious cell cul...
TRPC6 inactivation does not protect against diabetic kidney disease in streptozotocin (STZ)-treated Sprague-Dawley rats [0.03%]
_TRPC6失活不能保护链脲佐菌素(STZ)诱导的Sprague-Dawley大鼠糖尿病肾脏病变模型中的肾脏结构和功能损伤
Naghmeh Hassanzadeh Khayyat,Eun Young Kim,Stuart E Dryer
Naghmeh Hassanzadeh Khayyat
Canonical transient receptor potential-6 (TRPC6) channels have been implicated in the progression of several forms of kidney disease (1). While there is strong evidence that glomerular TRPC6 channels are dysregulated in diabetic nephropathy...
AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine [0.03%]
一种新的辅助T细胞表位AJP001能够激活先天免疫系统并引起体液免疫反应
Akiko Tenma,Hironori Nakagami,Hideki Tomioka et al.
Akiko Tenma et al.
Vaccine design requires well-tailored formulations including a T-cell epitope and adjuvants. We identified a novel cationic peptide, AJP001, which possesses a strong affinity for murine MHC class II alleles (H2-IEd and H2-IAd) and low affin...