Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: A review [0.03%]
肌肉质量的分子调控及一氧化氮的作用：综述性文章
Jun Kobayashi,Hiroyuki Uchida,Ayaka Kofuji et al.
Jun Kobayashi et al.
A variety of internal and external factors such as exercise, nutrition, inflammation, and cancer-associated cachexia affect the regulation of skeletal muscle mass. Because skeletal muscle functions as a crucial regulator of whole body metab...
Losing maleness: Somatic Y chromosome loss at every stage of a man's life [0.03%]
失去"男性": 人体的Y染色体在男子一生各个阶段中的丢失现象
Mami Miyado,Maki Fukami
Mami Miyado
Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired genetic variations in elderly people. Recent studies have linked aging-related mosaic LOY to the risk of Alzheimer's disease, cancer, and early death. Here, w...
Ralph A Bradshaw
Ralph A Bradshaw
Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation [0.03%]
胆汁酸受体激动剂在原发性胆汁性肝硬化中的作用：对胆管细胞分泌组及其下游T细胞分化的调节
Rachel E Etherington,Benjamin J M Millar,Barbara A Innes et al.
Rachel E Etherington et al.
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. Approximately 30% of patients do not respond to therapy with ursodeoxycholic acid (UDCA). Previous studies have implicated increased senescence of cholangiocytes in pa...
Phytohormone metabolism in human cells: Cytokinins are taken up and interconverted in HeLa cell culture [0.03%]
植物激素的人工合成及其在细胞中的转化：宫颈癌细胞（HeLa）可吸收并转化植物分裂素类生长物质
Megan M Aoki,Mark Seegobin,Anna Kisiala et al.
Megan M Aoki et al.
Cytokinins (CKs) encompass a group of phytohormones, known to orchestrate many critical processes in plant development. Excluding Archaea, CKs are pervasive among all kingdoms, but much less is reported about their metabolism beyond plants....
A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains [0.03%]
新型突变改变了PapA2的稳定性导致临床分枝杆菌菌株硫脂的完全丧失
Vipul Panchal,Nidhi Jatana,Anchal Malik et al.
Vipul Panchal et al.
The analysis of whole genomes has revealed specific geographical distribution of Mycobacterium tuberculosis (Mtb) strains across the globe suggestive of unique niche dependent adaptive mechanisms. We provide an important correlation of a ge...
Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus [0.03%]
N-丁酰谷胱甘肽衍生物(GSH-C4)诱导的谷胱甘肽增加通过抑制病毒复制并促进老年小鼠流感病毒感染后的Th1型免疫反应发挥保护作用
Donatella Amatore,Ignacio Celestino,Serena Brundu et al.
Donatella Amatore et al.
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses again...
Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe-mediated steatosis prevention and recovery [0.03%]
依折麦布介导的肝脂肪变性预防和恢复鉴定肝脏NPC1L1为非酒精性脂肪性肝病风险因素
Yu Toyoda,Tappei Takada,Masakazu Umezawa et al.
Yu Toyoda et al.
Non-alcoholic fatty liver disease (NAFLD) is a serious global public health concern. Nevertheless, there are no specific medications for treating the associated abnormal accumulation of hepatic lipids such as cholesterol and triglycerides. ...
Dengue NS5 modulates expression of miR-590 to regulate ubiquitin-specific peptidase 42 in human microglia [0.03%]
登革病毒NS5通过调节microRNA-590修饰人类小胶质细胞泛素特异性肽酶42的表达
Ritu Mishra,Vikas Sood,Akhil C Banerjea
Ritu Mishra
Dengue virus (DENV), a member of Flaviviridae family, has become neurovirulent in humans after rapid geographical expansion. Host proteasomal machinery contains both ubiquitin ligases as well as deubiquitinases (DUBs), known to influence ke...
Development of a whole-cell high-throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis [0.03%]
用于鉴定氨基酸生物合成抑制剂的结核分枝杆菌细胞高通量筛选体系的建立
Christopher Burke,Katherine A Abrahams,Emily J Richardson et al.
Christopher Burke et al.
Anti-tubercular drug discovery continues to be dominated by whole-cell high-throughput screening campaigns, enabling the rapid discovery of new inhibitory chemical scaffolds. Target-based screening is a popular approach to direct inhibitor ...