Kinetics of immune cell responses in the multiple low-dose streptozotocin mouse model of type 1 diabetes [0.03%]
多次低剂量链脲佐菌素小鼠1型糖尿病模型中免疫细胞反应的动力学研究
Zhengkang Luo,Charlotte Soläng,Mariela Mejia-Cordova et al.
Zhengkang Luo et al.
In type 1 diabetes (T1D), the insulin-producing β cells are destructed by immune mechanisms. It has been hypothesized that the very first immune response in T1D onset comes from innate immune cells, which further activates the adaptive imm...
Histone chaperone HIRA dictate proliferation vs differentiation of chronic myeloid leukemia cells [0.03%]
组蛋白分子伴侣HIRA决定慢性髓系白血病细胞增殖和分化方向
Aditi Majumder,Arya T Dharan,Ishita Baral et al.
Aditi Majumder et al.
Abnormal proliferation and disrupted differentiation of hematopoietic progenitors mark leukemia. Histone cell cycle regulator A (HIRA), a histone chaperone, regulates hemogenic to hematopoietic transition involved in normal hematopoiesis. B...
Expression of mutant CHMP2B linked to neurodegeneration in humans disrupts circadian rhythms in Drosophila [0.03%]
与人类神经退行性疾病相关的CHMP2B突变蛋白会干扰果蝇的昼夜节律
DaWon Lee,Xiaoyue Zheng,Kay Shigemori et al.
DaWon Lee et al.
Mutations in CHMP2B, an ESCRT-III (endosomal sorting complexes required for transport) component, are associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Neurodegenerative disorders including FTD are also ...
Weight loss is a sufficient and economical single outcome measure of murine dextran sulfate sodium colitis [0.03%]
体重下降是葡聚糖硫酸钠性小鼠结肠炎的一个足够有效且经济的单一结果测量标准
Savini Lanka Britto,Mahesh Krishna,Richard Kellermayer
Savini Lanka Britto
Inflammatory bowel diseases (IBD: Crohn's disease and ulcerative colitis) are becoming common around the world without a cure. Animal models of colitis have become instrumental in IBD research. The dextran sulfate sodium (DSS) induced murin...
Validation of extracellular miRNA quantification in blood samples using RT-qPCR [0.03%]
基于血液样本的外泌体miRNA定量的RT-qPCR验证方法
Maria Fauth,Anett B Hegewald,Lisa Schmitz et al.
Maria Fauth et al.
Extracellular microRNAs (miRs) have been proposed as important blood-based biomarkers for several diseases. Contrary to proteins and other RNA classes, miRs are stable and easily detectable in body fluids. In this respect, miRs represent a ...
IQGAP1 activates PLC-δ1 by direct binding and moving along microtubule with DLC-1 to cell surface [0.03%]
IQGAP1通过直接与PLC-δ1结合并沿着微管移动到细胞表面来激活PLC-δ1
Makoto Tanaka,Tomohiro Osanai,Yoshimi Homma et al.
Makoto Tanaka et al.
Phospholipase C (PLC)-δ1, activated by p122RhoGTPase-activating protein (GAP)/deleted in liver cancer-1 (p122RhoGAP/DLC-1), contributes to the coronary spastic angina (CSA) pathogenesis. The present study aims to further investigate the p1...
The Kinesin-3 motor, KLP-4, mediates axonal organization and cholinergic signaling in Caenorhabditis elegans [0.03%]
Kinesin-3马达蛋白KLP-4介导秀丽隐杆线虫轴突组织和胆碱能信号转导
Margaret E Magaletta,Kendall J Perkins,Catherine P Deuchler et al.
Margaret E Magaletta et al.
Microtubule plus-end directed trafficking is dominated by kinesin motors, yet kinesins differ in terms of cargo identity, movement rate, and distance travelled. Functional diversity of kinesins is especially apparent in polarized neurons, w...
Kras promotes myeloid differentiation through Wnt/β-catenin signaling [0.03%]
Kras通过Wnt/β-catenin信号促进髓样分化
Noriko Yokoyama,Yeon-Jeong Kim,Yoshio Hirabayashi et al.
Noriko Yokoyama et al.
Wild-type Kras, a small GTPase, inactivates Ras growth-promoting signaling. However, the role of Kras in differentiation of myeloid cells remains unclear. This study showed the involvement of Kras in a novel regulatory mechanism underlying ...
Kouki Shiina,Masaya Komatsu,Fumi Yokoi et al.
Kouki Shiina et al.
Oocyte spindle transfer (OST) is a potent reproductive technology used for mammals that enables the spindle in a deteriorated oocyte at the metaphase of the second meiotic division (MII) to serve as the genetic material for producing descen...
MicroRNA as novel biomarkers and therapeutic targets in diabetic kidney disease: An update [0.03%]
微小核糖核酸作为糖尿病肾病生物标志物和治疗靶点的新进展
Qinghua Cao,Xin-Ming Chen,Chunling Huang et al.
Qinghua Cao et al.
Diabetic kidney disease (DKD) is a life-limiting condition characterized by progressive and irreversible loss of renal function. Currently, the estimated glomerular filtration rate (eGFR) and albuminuria are used as key markers to define DK...