Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis [0.03%]
肺癌细胞通过上调胆固醇合成来应对表皮生长因子受体酪氨酸激酶抑制剂的暴露
Mark C Howell,Ryan Green,Roukiah Khalil et al.
Mark C Howell et al.
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide clinical benefits over chemotherapy for lung cancer patients with EGFR activating mutations. Despite initial clinical responses, long-term efficacy is not pos...
Pharmacological inhibition of STAT3 pathway ameliorates acute liver injury in vivo via inactivation of inflammatory macrophages and hepatic stellate cells [0.03%]
STAT3信号通路的药理学抑制通过使炎症巨噬细胞和肝星状细胞失活来改善急性肝脏损伤
Büsra Öztürk Akcora,Alexandros Vassilios Gabriël,Ana Ortiz-Perez et al.
Büsra Öztürk Akcora et al.
Liver diseases represent a major health problem worldwide, in particular, acute liver injury is associated with high mortality and morbidity. Inflammatory macrophages and hepatic stellate cells (HSCs) are known to be involved in the pathoge...
17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression [0.03%]
巨大芽孢杆菌细胞色素P450 BM-3生成的17(S),18(R)-环氧二十碳四烯酸通过G蛋白偶联受体40介导的中性粒细胞抑制作用来抑制接触性超敏反应的发展
Azusa Saika,Takahiro Nagatake,Shigenobu Kishino et al.
Azusa Saika et al.
Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a lipid metabolite endogenou...
Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B [0.03%]
人源DNA脱氨酶APOBEC3B的活性位点可塑性及其可能的化学抑制模式
Ke Shi,Özlem Demir,Michael A Carpenter et al.
Ke Shi et al.
The single-stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate immunity against viruses, but it is also strongly implicated in eliciting mutations in cancer genomes. Because of the critical role of A3B in promoting virus and ...
Changes in the R-region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel [0.03%]
R区域相互作用的变化取决于磷酸化并影响PKA和PKC对囊性纤维化跨膜传导调节因子氯通道的调节
Diogo R Poroca,Noha Amer,Audrey Li et al.
Diogo R Poroca et al.
The CFTR chloride channel is regulated by phosphorylation at PKA and PKC consensus sites within its regulatory region (R-region) through a mechanism, which is still not completely understood. We used a split-CFTR construct expressing the N-...
Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man [0.03%]
基于红外热像仪的社会认知表现的血管反应：从老鼠到人的转化研究
Jan Seidel,Fabian Bockhop,Miso Mitkovski et al.
Jan Seidel et al.
To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique "soci...
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy [0.03%]
细胞因子基因转染介导的肿瘤微环境改造可增强树突状细胞的免疫治疗效应
Daluthgamage Patsy Himali Wijesekera,Eiji Yuba,Nadeeka Harshini De Silva et al.
Daluthgamage Patsy Himali Wijesekera et al.
The tumor microenvironment strongly influences clinical outcomes of immunotherapy. By transfecting genes of relevant cytokines into tumor cells, we sought to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1...
Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence [0.03%]
阿司匹林通过抑制细胞衰老来改善多柔比星的长期不良反应
Mingxiao Feng,Joohwee Kim,Kevin Field et al.
Mingxiao Feng et al.
A number of childhood cancer survivors develop adverse, late onset side effects of earlier cancer treatments, known as the late effects of cancer therapy. As the number of survivors continues to increase, this growing population is at incre...
Cyclosporine A inhibits MRTF-SRF signaling through Na+/K+ ATPase inhibition and actin remodeling [0.03%]
环孢素A通过Na+/K+ATP酶抑制和肌动蛋白重塑抑制MRTF-SRF信号传导
Bastien Burat,Quentin Faucher,Petra Čechová et al.
Bastien Burat et al.
Calcineurin inhibitors (CNI) are the pillars of immunosuppression in transplantation. However, they display a potent nephrotoxicity whose mechanisms remained widely unsolved. We used an untargeted quantitative proteomic approach (iTRAQ tech...
Zeolites ameliorate asbestos toxicity in a transgenic model of malignant mesothelioma [0.03%]
丝光沸石通过转基因恶性间皮瘤小鼠模型的毒性作用研究
Xiyong Fan,Chris McLaughlin,Cleo Robinson et al.
Xiyong Fan et al.
Malignant mesothelioma (MM) is an almost invariably fatal cancer caused by asbestos exposure. The toxicity of asbestos fibers is related to their physicochemical properties and the generation of free radicals. We set up a pilot study to inv...