Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization [0.03%]
肝细胞生长因子在缺血性视网膜中表达上调，并促进血管渗漏及新生血管形成
Valeria E Lorenc,Raquel Lima E Silva,Sean F Hackett et al.
Valeria E Lorenc et al.
In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen-induced ischemic retinopathy suppo...
Elevation of the unfolded protein response increases RANKL expression [0.03%]
未折叠蛋白反应的激活可以上调破骨细胞分化因子RANKL的表达
Srividhya Iyer,Christian Melendez-Suchi,Li Han et al.
Srividhya Iyer et al.
Increased production of the osteoclastogenic cytokine RANKL is a common feature of pathologic bone loss, but the underlying cause of this increase is poorly understood. The unfolded protein response (UPR) is activated in response to accumul...
Pseudomonas Quinolone Signal molecule PQS behaves like a B Class inhibitor at the IQ site of mitochondrial complex I [0.03%]
铜绿假单胞菌喹诺酮信号分子PQS在复合物I的IQ位点的行为表现类似于B类抑制剂
Bettina Rieger,Sven Thierbach,Miriam Ommer et al.
Bettina Rieger et al.
Pseudomonas aeruginosa is a Gram-negative bacterium of the proteobacteria class, and one of the most common causes of nosocomial infections. For example, it causes chronic pneumonia in cystic fibrosis patients. Patient sputum contains 2-hep...
Hypothesis: Chemical activity regulates and coordinates the processes maintaining glycerophospholipid homeostasis in mammalian cells [0.03%]
假说：化学活性调节和协调维持哺乳动物细胞甘油磷脂稳态的过程
Pentti Somerharju,Jorma A Virtanen,Martin Hermansson
Pentti Somerharju
Mammalian cells maintain the complex glycerophospholipid (GPL) class compositions of their various membranes within close limits because this is essential to their well-being or viability. Surprisingly, however, it is still not understood h...
Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons [0.03%]
Gas7基因敲除影响小鼠皮层神经元中PINK1的表达及线粒体动力学
Jagannatham Naidu Bhupana,Bo-Tsang Huang,Gunn-Guang Liou et al.
Jagannatham Naidu Bhupana et al.
Dynamic fission and fusion events regulate mitochondrial shape, distribution, and rejuvenation, and proper control of these processes is essential for neuronal homeostasis. Here, we report that Gas7, a known cytoskeleton regulator, controls...
Nucleic acid detection aboard the International Space Station by colorimetric loop-mediated isothermal amplification (LAMP) [0.03%]
基于国际空间站上的环介导等温扩增(LAMP)的核酸检测
Julian Rubinfien,Kutay D Atabay,Nicole M Nichols et al.
Julian Rubinfien et al.
Human spaceflight endeavors present an opportunity to expand our presence beyond Earth. To this end, it is crucial to understand and diagnose effects of long-term space travel on the human body. Developing tools for targeted, on-site detect...
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells [0.03%]
脱氢表雄酮对浦肯野细胞的神经保护作用：小脑与松果体的差异性
Kazuyoshi Tsutsui,Shogo Haraguchi
Kazuyoshi Tsutsui
The brain produces steroids de novo from cholesterol, so-called "neurosteroids." The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from ...
Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma [0.03%]
肿瘤坏死因子受体-2信号通路促进透明细胞肾癌中CD133+类癌症干细胞的存活
John R Bradley,Jun Wang,Simon Pacey et al.
John R Bradley et al.
Clear cell renal cell carcinoma (ccRCC) contains cancer stem-like cells (CSCs) that express CD133 (ccRCC-CD133+). CSCs are rarely in cell cycle and, as nonproliferating cells, resist most chemotherapeutic agents. Previously, we reported tha...
Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers? [0.03%]
不对称的翻译后修饰能否调控STAT3同源二聚体的行为？
Ricardo Letra-Vilela,Beatriz Cardoso,Catarina Silva-Almeida et al.
Ricardo Letra-Vilela et al.
Signal transducer and activator of transcription 3 (STAT3) is a ubiquitous and pleiotropic transcription factor that plays essential roles in normal development, immunity, response to tissue damage and cancer. We have developed a Venus-STAT...
Ultrastructure of primary pacemaking cells in rabbit sino-atrial node cells indicates limited sarcoplasmic reticulum content [0.03%]
兔窦房结起搏细胞的超微结构表明其肌浆网含量有限
Ramesh Iyer,Oliver Monfredi,Manuela Lavorato et al.
Ramesh Iyer et al.
The main mammalian heart pacemakers are spindle-shaped cells compressed into tangles within protective layers of collagen in the sino-atrial node (SAN). Two cell types, "dark" and "light," differ on their high or low content of intermediate...