Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction [0.03%]
TMEM16A的增强并不能刺激气道粘液分泌或支气管和肺动脉平滑肌收缩
Henry Danahay,Roy Fox,Sarah Lilley et al.
Henry Danahay et al.
The calcium-activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and...
The regulatory role of PGC1α-related coactivator in response to drug-induced liver injury [0.03%]
PGC1α相关共激活因子在药物性肝损伤反应中的调控作用
Marcin Buler,Thomas Naessens,Johan Mattsson et al.
Marcin Buler et al.
PGC1α-Related Coactivator (PRC) is a transcriptional coactivator promoting cytokine expression in vitro in response to mitochondrial injury and oxidative stress, however, its physiological role has remained elusive. Herein we investigate a...
Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases [0.03%]
转录组分析斑马鱼atoh7-/-突变体lakritz高亮了Atoh7依赖的遗传网络及其对人类眼病的影响
Giuseppina Covello,Fernando J Rossello,Michele Filosi et al.
Giuseppina Covello et al.
Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. Several studies have emerged establishing ATOH7 as a retinal disease gen...
Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSCs) enhances Nanog expression and provides a serum-free condition for exosome isolation [0.03%]
牙髓多能类干细胞的三维培养增强NANOG表达并在无血清条件下促进外泌体的分离
Farid N Faruqu,Shuai Zhou,Noor Sami et al.
Farid N Faruqu et al.
Stem cell-derived exosomes have been identified as novel cell-free therapeutics for regenerative medicine. Three-dimensional (3D) culture of stem cells were reported to improve their "stemness" and therapeutic efficacy. This work focused on...
Metabolic response of Insulinoma 1E cells to glucose stimulation studied by fluorescence lifetime imaging [0.03%]
荧光寿命成像技术研究胰岛素瘤细胞系1E的葡萄糖刺激代谢响应
Gianmarco Ferri,Marta Tesi,Federico Massarelli et al.
Gianmarco Ferri et al.
A cascade of highly regulated biochemical processes connects glucose stimulation to insulin secretion in specialized cells of mammalian pancreas, the β-cells. Given the importance of this process for systemic glucose homeostasis, noninvasi...
Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma [0.03%]
神经生长因子及其受体酪氨酸激酶TrkA在宫颈鳞状细胞癌中的高表达
Sam Faulkner,Nathan Griffin,Christopher W Rowe et al.
Sam Faulkner et al.
Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNG...
Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke [0.03%]
肌肉特异性激活Sirtuin1改善脑卒中后肌萎缩小鼠模型中的骨骼肌萎缩
Kiril Tuntevski,Ameena Hajira,Austin Nichols et al.
Kiril Tuntevski et al.
Stroke causes severe long-term disability in patients due to the induction of skeletal muscle atrophy and weakness, but the molecular mechanisms remain elusive. Using a preclinical mouse model of cerebral ischemic stroke, we show that strok...
Low bone mineral density due to secondary hyperparathyroidism in the GlatmTg(CAG-A4GALT) mouse model of Fabry disease [0.03%]
由于戈谢模型中法布雷病继发性甲状旁腺功能亢进导致的骨密度降低
Hiroki Maruyama,Atsumi Taguchi,Mariko Mikame et al.
Hiroki Maruyama et al.
Low bone mineral density (BMD)-diagnosed as osteoporosis or osteopenia-has been reported as a new characteristic feature of Fabry disease; however, the mechanism underlying the development of low BMD is unknown. We previously revealed that ...
Depleting interferon regulatory factor-1(IRF-1) with CRISPR/Cas9 attenuates inducible oxidative metabolism without affecting RA-induced differentiation in HL-60 human AML cells [0.03%]
CRISPR/Cas9敲除干扰素调节因子-1（IRF-1）可减弱诱导型氧化代谢，而不影响IRF-1缺失对RA诱导分化的HL-60急性髓系白血病细胞的作用
Kaiyuan Zhu,Jianbo Yue,Andrew Yen
Kaiyuan Zhu
The known collaboration between all-transretinoic acid and interferon motivates this study of the dependence of RA-induced leukemic cell differentiation on interferon regulatory factor-1 (IRF-1), a transcription factor that is the main medi...
LCRF-0006, a small molecule mimetic of the N-cadherin antagonist peptide ADH-1, synergistically increases multiple myeloma response to bortezomib [0.03%]
LCRF-0006是一种小分子，是N-钙黏素拮抗肽ADH-1的模拟物，可协同增强硼替佐米对多发性骨髓瘤的疗效
Krzysztof M Mrozik,Chee M Cheong,Duncan R Hewett et al.
Krzysztof M Mrozik et al.
N-cadherin is a homophilic cell-cell adhesion molecule that plays a critical role in maintaining vascular stability and modulating endothelial barrier permeability. Pre-clinical studies have shown that the N-cadherin antagonist peptide, ADH...