Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy [0.03%]
糖尿病肾病中蛋白质稳态和糖脂代谢的昼夜重构
Xiao-Qian Li,Lei Cheng,Tian-Fen Chen et al.
Xiao-Qian Li et al.
Dysfunction of the circadian clock has been implicated in the pathogenesis of various diseases, including metabolic disorders, inflammatory conditions, and cancer. While the significance of circadian rhythm in diabetic nephropathy is gainin...
Correction to "Interoceptive Information of Physical Vigor Through Circulating Insulin-Like Growth Factor 1" [0.03%]
对《通过循环生长素IGF-1感知身体活力的内部感觉信息》一文的更正
[This corrects the article DOI: 10.1096/fba.2025-00226.]. © 2026 The Author(s). FASEB BioAdvances published by the Federation of American Societies for ...
Published Erratum
FASEB bioAdvances. 2026 Feb 11;8(2):e70093. DOI:10.1096/fba.2026-00036 2026
The Scientific Case for Animal Models: A Perspective From Musculoskeletal Researchers [0.03%]
从肌骨系统研究人员的角度看实验动物模型的科学依据
Michael Hadjiargyrou,Blake E Hildreth rd,Frank Ko et al.
Michael Hadjiargyrou et al.
The National Institutes of Health (NIH) has launched a major initiative to expand human-based New Approach Methodologies (NAMs) in biomedical research and reduce reliance on animal models. While NAMs offer powerful complementary tools, anim...
Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice [0.03%]
线粒体DNA杂合突变小鼠去神经对骨骼肌线粒体的影响
Takanaga Shirai,Hideto Hanakita,Kohei Takeda et al.
Takanaga Shirai et al.
Mitochondrial function is essential for skeletal muscle health, and its disruption leads to atrophy and functional decline. This study examines the impact of denervation on skeletal muscle mitochondria in polymerase gamma (PolG)(+/mut) mice...
Age and Sex Impact the Role of Thrombospondin-2 and Thrombospondin-5 in Response to Hindlimb Ischemia [0.03%]
年龄和性别对血小板源性生长因子-Thmbospondin-2和Thmbospondin-5响应hindlimb缺血的影响
Ashley A Peters,Melissa Rangel,Corinne Bunn et al.
Ashley A Peters et al.
Peripheral arterial disease progression to critical limb ischemia remains a significant burden in the aged, necessitating revascularization. Therapies to enhance neovascularization, such as angiogenesis or arteriogenesis, may provide an opt...
Keratinocyte-Associated Biomarkers Reveal Pathogenic Mechanisms in Acne [0.03%]
黑素细胞相关生物标志物揭示了痤疮的致病机制
Sini Cai,Yinjing Lin,Heng Xie et al.
Sini Cai et al.
The cellular and molecular complexity of acne pathogenesis has hindered progress toward effective targeted therapies. While keratinocytes are known to influence skin inflammation, their precise transcriptional programs and regulatory circui...
Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice [0.03%]
口服牛胸腺提取物可减轻衰老小鼠的神经元兴奋性
Abdeslem El-Idrissi,Natalia Surzenko,Bassem F El-Khodor
Abdeslem El-Idrissi
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Many aspects of GABAergic neurotransmission, including the densities of GABAergic neurons, the synthesis of GABA and its interact...
Diabetes Induces Accumulation of Carbonylated Proteins in the Rat Retinal Pigment Epithelium Independently of Oxidative Stress [0.03%]
糖尿病通过独立于氧化应激的机制诱导羰基化蛋白在大鼠视网膜色素上皮中的聚集
Elena Morales-Ramírez,Juan David Villeda-González,Gustavo Sánchez-Chávez et al.
Elena Morales-Ramírez et al.
Diabetic retinopathy (DR) is a major complication of diabetes mellitus. Growing evidence shows that hyperglycemia causes not only microvascular damage but also retinal neural dysfunction. Although different metabolic pathways have been impl...
Increased Orexin by High Concentration of Sevoflurane Enhances the Suprahyoid Muscle Activity Involves in Gasping-Like Respiration of Mice [0.03%]
高浓度七氟醚通过增加下丘脑分泌素神经元活性增强小鼠类似喘息的呼吸运动
Yoko Irukayama-Tomobe,Jun-Dal Kim,Hisayo Jin et al.
Yoko Irukayama-Tomobe et al.
Gasping respiration enhances survival chances during cardiac arrest by activating the suprahyoid muscles (SHMs), which are crucial for airway dilation. We previously reported that the high concentration of sevoflurane (6.5%: 2.0 minimum alv...
Unlocking the Power of CXCR2 Inhibition to Overcome Gemcitabine Resistance in Pancreatic Cancer [0.03%]
CXCR2抑制剂克服吉西他滨耐药在胰腺癌的应用研究
Caitlin Molczyk,Reegan Sturgeon,Sugandha Saxena et al.
Caitlin Molczyk et al.
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality, characterized by intrinsic resistance to conventional therapies and limited effective treatment options. In this study, we investigated the rol...