The Oxygen Equivalent of Lactate Accumulation and Sex: Similar Work-Lactate Slopes in Men and Women Regardless of Body or Fat-Free Mass Scaling [0.03%]
氧合当量积累和性别：无论以身体或去脂体重比例换算，男性和女性在相同工作量下的乳酸增量相似
Benedikt Meixner,Mascha Lenk,Billy Sperlich
Benedikt Meixner
The oxygen equivalent of blood lactate accumulation (ΔLa) is commonly expressed relative to body mass (BM), yet BM includes adipose tissue which does not substantially contribute to glycolytic energy production nor lactate distribution spa...
Temperature-Gradient Transcriptomic Atlas Reveals the PPAR Signaling Pathway Dysfunction in Heat Stroke Induced Liver Injury [0.03%]
温度梯度转录组揭示热射病致肝脏损伤的PPAR信号通路异常
Ying Zhu,Wanlin Liu,Chunyuan Yang et al.
Ying Zhu et al.
Heat stroke (HS) is the most severe form of hyperthermia, with mortality exceeding 50% in severe cases. The liver is highly vulnerable to HS-induced injury, often triggering multi-organ failure. Although rapid cooling remains the primary tr...
Therapeutic Potential of Lentiviral miR-200a Mimics in Regulating Fibrinolysis and EMT Markers During Pulmonary Fibrosis [0.03%]
lentiviral-miR-200a 在肺纤维化中调节纤溶及上皮间质转化的治疗潜力
T M Jeena,C Rakshitha,Akarsha B Jain et al.
T M Jeena et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by the excessive accumulation of collagen-rich extracellular matrix (ECM), leading to the replacement of normal lung architecture. This pathological remodeling is p...
Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells [0.03%]
严重缺氧降低气道上皮细胞腺苷酸环化酶6的表达与功能
Ryan H Cunnington,Nisha Singh,Marziyeh Shafizadeh et al.
Ryan H Cunnington et al.
Hypoxia is associated with a range of maladies, inflammation, and impaired immunity. The airway epithelial barrier contends with constant exposure to microbes but can be weakened with hypoxia and diseases, such as cystic fibrosis (CF). Peop...
A TLR8 Variant Identified From Whole Exome Sequencing as a Sepsis-Prone Mutation [0.03%]
从外显子组测序中鉴定的一种Sepsis易感突变的TLR8变异体
Fahd Alhamdan,Stefano Gianoli,Xioahui Han et al.
Fahd Alhamdan et al.
Sepsis remains a leading cause of morbidity and mortality worldwide, with outcomes highly influenced by host immune responses. While environmental and pathogen-related factors are well recognized, the contribution of host genomic variants t...
Transamniotic Fetal Delivery of Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) mRNA [0.03%]
囊性纤维化跨膜传导调节器(mRNA)的宫内注射
Kamila Moskowitzova,Ashlyn E Whitlock,Yash V Shroff et al.
Kamila Moskowitzova et al.
We sought to determine whether a cystic fibrosis transmembrane conductance regulator (CFTR) mRNA could be administered to the fetus via the transamniotic route as a potential strategy for the perinatal management of cystic fibrosis-associat...
Pulmonary Endothelial Extracellular Vesicles Preferentially Interact and Are Processed in Pulmonary Endothelial Cells [0.03%]
肺内皮细胞外囊泡优先相互作用并被肺内皮细胞加工
Aritra Bhadra,April Scruggs,April Haven et al.
Aritra Bhadra et al.
Extracellular vesicles (EVs) regulate vascular injury and homeostasis; however, the intracellular mechanisms for the EV effects are unknown. While EV components and functions are well studied, their cellular uptake and intracellular process...
Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase-Specific Biomarkers [0.03%]
儿童脓毒症血浆蛋白质组特征揭示了持续性炎症和分期特异性生物标志物
Fahd Alhamdan,Yi-Cheng Sin,Erik Malm et al.
Fahd Alhamdan et al.
Sepsis remains a leading cause of pediatric morbidity and mortality, yet its molecular underpinnings are poorly understood. Here, we performed mass spectrometry-based plasma proteomics and cytokine profiling in pediatric sepsis patients at ...
Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions [0.03%]
小鼠肠道经上皮通透性的图谱：生理及刺激条件下的区域和细胞间差异性
Mathilde Miquel,Kadirey Verwaerde,Anissa Edir-Kibri et al.
Mathilde Miquel et al.
Intestinal paracellular permeability was analyzed ex vivo by incubation of tissue segments at 0°C with the fluorescent dyes FM1-43FX (FM) or TRITC-dextran 3 kDa lysine-fixable (TD3L) and confocal microscopy in (i) healthy mice and (ii) mic...
Boosting Cuproptosis in Breast Cancer Therapy via Photodynamic Treatment With a New Liposome [0.03%]
通过新的脂质体光动力治疗增强乳腺癌治疗中的铜死亡
Jie Yu,Ning Sun,Limei You et al.
Jie Yu et al.
Breast cancer (BC) is one of the most common cancers in women around the world, and utilizing a combined approach is a crucial strategy. Induction of cuproptosis in tumor cells is a novel antitumor approach, though its standalone efficacy r...