Standing strong: War-related challenges in Ukrainian biomedical research and opportunities for support [0.03%]
逆境中的坚韧：乌克兰生物医学研究面临的战争挑战及其机遇支持
Hubert Hondermarck,Nataliya Finiuk,Chen Chen Jiang et al.
Hubert Hondermarck et al.
The prolonged war in Ukraine is having a strong impact on all sectors of the Ukrainian society, including biomedical research. Although the material and psychological conditions are challenging, the country and its researchers are courageou...
Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes [0.03%]
胞内TAS2R充当角质形成细胞中ABCB1通过途径排出有害物质的守门人作用
Sazanami Mori,Natsuki Nakamura,Ayane Fuchigami et al.
Sazanami Mori et al.
Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non-taste perception and tissue-specific functions. Keratinocytes that express TAS2Rs in the skin pro...
Microfluidics-A novel technique for high-quality sperm selection for greater ART outcomes [0.03%]
微流控技术在高精密度精子筛选中的应用及前景
Ghulam Rasool Bhat,Farooz Ahmad Lone,Jasmer Dalal
Ghulam Rasool Bhat
Microfluidics represent a quality sperm selection technique. Human couples fail to conceive and this is so in a significant population of animals worldwide. Defects in male counterpart lead to failure of conception so are outcomes of assist...
AAV-mouse DNase I sustains long-term DNase I expression in vivo and suppresses breast cancer metastasis [0.03%]
AAV小鼠DNase I可持续体内DNase I长期表达并抑制乳腺癌转移
Melanie Herre,Kalyani Vemuri,Jessica Cedervall et al.
Melanie Herre et al.
Neutrophil extracellular traps (NETs) have been implicated in the pathology of various inflammatory conditions. In cancer, NETs have been demonstrated to induce systemic inflammation, impair peripheral vessel and organ function and promote ...
Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H [0.03%]
人源单克隆抗体1b1具有针对脑膜炎奈瑟球菌结合蛋白变体2的杀菌活性并能置换人类补体因子h
Daniele Veggi,Chelsy C Chesterman,Laura Santini et al.
Daniele Veggi et al.
Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries. Two vaccines, 4CMenB an...
Tristetraprolin mediates immune evasion of mycobacterial infection in macrophages [0.03%]
巨噬细胞中三联四プロ林介导分枝杆菌感染的免疫逃避作用
Jiawei Wei,Huan Ning,Octavio Ramos-Espinosa et al.
Jiawei Wei et al.
Immune evasion of Mycobacterium tuberculosis (Mtb) facilitates intracellular bacterial growth. The mechanisms of immune evasion, however, are still not fully understood. In this study, we reveal that tristetraprolin (TTP), one of the best c...
Oxidative stress mediates nucleocytoplasmic shuttling of KPNA2 via AKT1-CDK1 axis-regulated S62 phosphorylation [0.03%]
氧化应激通过AKT1-CDK1轴调控的S62磷酸化介导KPNA2核质穿梭作用
Jie-Xin Huang,Chun-I Wang,Chia-Yu Kuo et al.
Jie-Xin Huang et al.
Karyopherin α 2 (KPNA2, importin α1), a transport factor shuttling between the nuclear and cytoplasmic compartments, is involved in the nuclear import of proteins and participates in cellular processes such as cell cycle regulation, apopt...
Social defeat stress impairs systemic iron metabolism by activating the hepcidin-ferroportin axis [0.03%]
社会失败压力通过激活肝素素-铁调素-铁转运蛋白轴损伤系统性铁代谢
Emiko Kasahara,Ayumi Nakamura,Kenki Morimoto et al.
Emiko Kasahara et al.
Chronic psychological stress has been reported to decrease circulating iron concentrations and impair hematopoiesis. However, the underlying mechanisms remain unclear. This study aimed to investigate the effects of psychological stress on b...
Consequences of gene editing of PRLR on thermotolerance, growth, and male reproduction in cattle [0.03%]
基因编辑PRLR对牛耐热性、生长和雄性繁殖的影响
Camila J Cuellar,Thiago F Amaral,Paula Rodriguez-Villamil et al.
Camila J Cuellar et al.
Global warming is a major challenge to the sustainable and humane production of food because of the increased risk of livestock to heat stress. Here, the example of the prolactin receptor (PRLR) gene is used to demonstrate how gene editing ...
Bile acids differentially regulate longitudinal smooth muscle contractility in everted mouse ileum [0.03%]
胆酸通过调节回肠平滑肌收缩来影响肠道运动
Peace N Dike,Krishnakant G Soni,Diana S Chang et al.
Peace N Dike et al.
Bile acids regulate gastrointestinal motility by mechanisms that are poorly understood. Standard isolated tissue bath assays might not recapitulate in vivo physiology if contractile responses to certain bile acids require direct application...