G protein coupled receptor in apoptosis and apoptotic cell clearance [0.03%]
G蛋白偶联受体在细胞凋亡及凋亡细胞清除中的作用
Xinyan Li,Chao Li,Yang Kang et al.
Xinyan Li et al.
Apoptosis is a genetically programmed form of cell death that is substantially conserved across the evolutionary tree. Apoptotic cell elimination includes recognition, phagocytosis, and degradation. Failure to clear apoptotic cells can ulti...
In vivo optical assessment of cerebral and skeletal muscle microvascular response to phenylephrine [0.03%]
肾上腺素能血管收缩剂苯福林对脑和骨骼肌微血管反应的体内光学检测方法研究
Laura Mawdsley,Rasa Eskandari,Farah Kamar et al.
Laura Mawdsley et al.
This study aimed to investigate the simultaneous response of the cerebral and skeletal muscle microvasculature to the same phenylephrine (PE) boluses. A hybrid optical system that combines hyperspectral near-infrared spectroscopy (hs-NIRS) ...
Mouse developmental defects, but not paraganglioma tumorigenesis, upon conditional Complex II loss in early Sox10+ cells [0.03%]
条件性缺失早期Sox10阳性细胞中的複合体II导致小鼠发育缺陷，但不引发副神经节瘤肿瘤发生
Elizabeth P Lewis,Fatimah Al Khazal,Brandon Wilbanks et al.
Elizabeth P Lewis et al.
In humans, loss of heterozygosity for defective alleles of any of the four subunits of mitochondrial tricarboxylic acid cycle enzyme succinate dehydrogenase (SDH, also Complex II of the electron transport chain) can lead to paraganglioma tu...
Gene expression analysis identifies hub genes and pathways distinguishing fatal from survivor outcomes of Ebola virus disease [0.03%]
基因表达分析识别出埃博拉病毒感染致死与存活结局的区别基因及途径
Melvin Mensah-Bonsu,Christopher Doss,Clay Gloster et al.
Melvin Mensah-Bonsu et al.
The Ebola virus poses a severe public health threat, yet understanding factors influencing disease outcomes remains incomplete. Our study aimed to identify critical pathways and hub genes associated with fatal and survivor Ebola disease out...
Reduction of pathological retinal neovascularization, vessel obliteration, and artery tortuosity by PEDF protein in an oxygen-induced ischemic retinopathy rat model [0.03%]
PEDF蛋白减少缺血性视网膜病变模型 rats 中病理性视网膜新生血管、血管闭塞和动脉纡曲变形
Shiying Zhao,Alexander V Tschulakow,Subha S Karthikeyan et al.
Shiying Zhao et al.
Retinopathy of prematurity (ROP) is a severe retinal disease in premature infants characterized by pathological neovascularization, obliteration of retinal vessels and increased vessel tortuosity. Currently, there are no completely satisfac...
Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS [0.03%]
长链脂肪酸氧化先天性错误导致 Toll 样受体 4 配体 LPS 的炎症反应受损
Signe Mosegaard,Krishna S Twayana,Simone W Denis et al.
Signe Mosegaard et al.
Stimulation of mammalian cells with inflammatory inducers such as lipopolysaccharide (LPS) leads to alterations in activity of central cellular metabolic pathways. Interestingly, these metabolic changes seem to be important for subsequent r...
Activation of nociception-sensitive ionotropic glutamate receptor-expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats [0.03%]
心脏传入刺激激活大鼠背外侧延髓痛觉敏感的离子型谷氨酸受体表达神经元
Matthew R Zahner,Cade C Oculam,Eric Beaumont
Matthew R Zahner
Myocardial ischemia causes the release of bradykinin, which activates afferent nerve endings in the ventricular epicardium. This elicits a sympathetically mediated increase in arterial pressure and heart rate, referred to as the cardiogenic...
Insights on pathophysiology of hydrocephalus rats induced by kaolin injection [0.03%]
卡介苗诱发的脑积水_rat病理生理学的新见解
Kuo Zhang,Wanqi Zhou,Huijie Yu et al.
Kuo Zhang et al.
Hydrocephalus can affect brain function and motor ability. Current treatments mostly involve invasive surgeries, with a high risk of postoperative infections and failure. A successful animal model plays a significant role in developing new ...
Osteocalcin binds to a GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling [0.03%]
骨钙素结合到GPRC6A的别构 Venus捕蝇器位点以正向调节GPRC6A信号转导
Rupesh Agarwal,Ruisong Ye,Micholas Dean Smith et al.
Rupesh Agarwal et al.
GPRC6A, a member of the Family C G-protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L-amino acids, the osteocalcin (Ocn) peptide and the steroid hormon...
An unidentified yet notable modification on I Na and I K (DR) caused by ramelteon [0.03%]
拉莫特罗引起的未知但显著的I Na和I K(DR)变化
Po-Ming Wu,Yi-Fang Tu,Hsin-Yen Cho et al.
Po-Ming Wu et al.
Despite advancement in anti-seizure medications, 30% of patients continue to experience recurrent seizures. Previous data indicated the antiepileptic properties of melatonin and its agonists in several animal models. However, the underlying...