The impact of mild episodic ketosis on microglia and hippocampal long-term depression in 5xFAD mice [0.03%]
中度生酮对5XFAD小鼠的小胶质细胞和海马长期抑制的影响
Jacopo Di Lucente,Jon J Ramsey,Lee-Way Jin et al.
Jacopo Di Lucente et al.
Ketotherapeutics is a potential metabolic intervention for mitigating dementias; however, its mechanisms and optimal methods of application are not well understood. Our previous in vitro study showed that β-hydroxybutyrate (BHB), a major k...
CREB coactivator CRTC1 in melanocortin-4 receptor-expressing cells regulate dietary fat intake [0.03%]
小清蛋白调节素CRTC1通过表达黑素皮质素受体4的细胞调控膳食脂肪摄入量
Shigenobu Matsumura,Miyu Fujisawa,Mizuki Fujiwara et al.
Shigenobu Matsumura et al.
Cyclic adenosine monophosphate-response element-binding protein-1-regulated transcription coactivator-1 (CRTC1), a cytoplasmic coactivator that translocates to the nucleus in response to cAMP, is associated with obesity. We previously repor...
New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone [0.03%]
钙结合荧光染料茜素紫络合物在检测软骨渗透性方面的新作用——向软骨下骨方向渗透
Mingshu Cui,Mengcun Chen,Yanmei Yang et al.
Mingshu Cui et al.
Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by the progressive deterioration of articular cartilage and concomitant alterations in subchondral bone architecture. However, the precise mechanisms underlying the ...
Everything, everywhere, and all at once: A blueprint for supra-organization of core facilities [0.03%]
无所不在，统筹兼顾——核心设施超机构组织蓝图
Tsiona Elkayam Cohen,Robert Fluhr
Tsiona Elkayam Cohen
Core facilities are crucial for cutting-edge scientific research in academic institutions, yet they place a significant financial burden on budgets. The viability of these facilities can be improved through cross-institutional collaboration...
Epigenetic regulation of cardiovascular diseases induced by behavioral and environmental risk factors: Mechanistic, diagnostic, and therapeutic insights [0.03%]
行为和环境危险因素诱发的心血管疾病的表观遗传调控：机制、诊断及治疗新见解
Feifei Bi,Chen Gao,Hongchao Guo
Feifei Bi
Behavioral and environmental risk factors are critical in the development and progression of cardiovascular disease (CVD). Understanding the molecular mechanisms underlying these risk factors will offer valuable insights for targeted preven...
TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β-catenin signaling through an increase in ILK expression [0.03%]
TMEM182通过增加ILK表达维持Wnt/β-catenin信号传导的活化状态从而抑制人类iPS细胞心肌分化
Hirofumi Morihara,Shunichi Yokoe,Shigeo Wakabayashi et al.
Hirofumi Morihara et al.
Transmembrane protein 182 (TMEM182) is notably abundant in muscle and adipose tissue, but its role in the heart remains unknown. This study examined the contribution of TMEM182 in the differentiation of human induced pluripotent stem cells ...
Gut microbiota and autoimmune diseases: Insights from Mendelian randomization [0.03%]
肠道微生物群与自身免疫性疾病：孟德尔随机化研究的启示
Fangxiang Mu,Gusbakti Rusip,Florenly Florenly
Fangxiang Mu
In recent years, the scientific community has shown interest in the role of gut microbiota in the development of autoimmune diseases (AID). Although observational studies have revealed significant associations between gut microbiota and AID...
Medium-chain fatty acid receptor GPR84 deficiency leads to metabolic homeostasis dysfunction in mice fed high-fat diet [0.03%]
中链脂肪酸受体GPR84缺乏导致高脂饮食小鼠代谢稳态失调
Akari Nishida,Ryuji Ohue-Kitano,Yuki Masujima et al.
Akari Nishida et al.
Overconsumption of food, especially dietary fat, leads to metabolic disorders such as obesity and type 2 diabetes. Long-chain fatty acids, such as palmitoleate are recognized as the risk factors for these disorders owing to their high-energ...
Single-cell and spatial transcriptomics: Discovery of human placental development and disease [0.03%]
单细胞和空间转录组学在人类胎盘发育和疾病发现中的应用
Mi Tang,Liling Xiong,Jianghui Cai et al.
Mi Tang et al.
The human placenta is a vital organ, encompassing many distinct cell types, that maintains the growth and development of the fetus and is essential for substance exchange, defense, synthesis, and immunity. Abnormalities in placental cells c...
Mitochondrial functional impairment in ARL3-mutation related rod-cone dystrophy [0.03%]
ARL3突变相关视杆锥皮质盲小鼠模型的线粒体功能损伤
Xiaoli Zhang,Shun Yao,Lujia Zhang et al.
Xiaoli Zhang et al.
Mitochondria are vital for retinal cell function and survival, and there is growing evidence linking mitochondrial dysfunction to retinal degenerations. Although ARL3 mutations have been linked to multiple forms of retinal degeneration, the...