Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water? [0.03%]
反应碳原子是否通过富集生物体内水中的氘来降低生化体系中重水的比例？
Stephanie Seneff,Greg Nigh,Anthony M Kyriakopoulos
Stephanie Seneff
Deuterium is a natural heavy isotope of hydrogen, having a neutron as well as a proton. Deuterium disrupts ATP synthesis in mitochondria, causing increased production of reactive oxygen species and reduced synthesis of ATP. Gut microbes lik...
Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine [0.03%]
整体精准健康：利用人工智能、生物医学信息学和临床医学开辟下一代精准医疗的道路
Sawsan G A A Mohammed,M Walid Qoronfleh,Ahmet Acar et al.
Sawsan G A A Mohammed et al.
A "quiet revolution" in medicine has been taking place over the past two decades. There are two converging dynamic forces that have propelled precision medicine to the limelight, garnering wide public attention. The first driver is the real...
Hydrochlorothiazide combined with exercise training attenuates blood pressure variability and renal dysfunctions in an experimental model of hypertension and ovarian hormone deprivation [0.03%]
氢氯噻嗪联合运动训练可减轻高血压和卵巢激素缺乏模型中的血压变异性和肾功能障碍
Pietra Petrica Neves,Maycon Junior Ferreira,Tânia Plens Shecaira et al.
Pietra Petrica Neves et al.
Considering that blood pressure variability (BPV) has been associated with damage to target organs such as the kidneys, this study aimed to investigate the effects of the association of hydrochlorothiazide (HCTZ) combined with exercise trai...
Network expression analysis identifies and experimentally validates the involvement of Fosb in acute kidney injury [0.03%]
网络表达分析鉴定并实验验证FOSB在急性肾损伤中的作用
Xiaoyan Tang,Changqiong Shen,Chunqiu Liu et al.
Xiaoyan Tang et al.
Acute kidney injury (AKI) is a complex clinical syndrome associated with increased incidence and mortality rates among critically ill patients, often leading to multiple organ dysfunction, which underscores the need to better understand its...
Characterization of the Rbfox3-IRES-iCre knock-in mouse: Revealing gene recombination activity in neural and non-neural peripheral tissues [0.03%]
Rbfox3-IRES-iCre敲入小鼠的特征分析及其在神经组织和非神经外周组织中的基因重组活性研究
Shiho Nishino,Misuzu Hashimoto,Swapna Paramanya Biswas et al.
Shiho Nishino et al.
In vivo cell type-specific genetic recombination based on the Cre-loxP system has contributed to the understanding of biological processes and diseases. Neuronal nuclei (NeuN)/RBFOX3 is a widely used mature neuron marker in developmental bi...
Global warming and obesity: External heat exposure as a modulator of energy balance [0.03%]
全球变暖与肥胖：外部热暴露对能量平衡的调节作用
Imani Muhammad,Francene Steinberg,Jennifer Larsen et al.
Imani Muhammad et al.
In obesity research, the importance of core body temperature (CBT) regulation is often neglected. CBT thermogenic regulation, however, plays a crucial role in heat management through convection, radiation, and conduction processes to remove...
Chronic treatment of old mice with AICAR reverses age-related changes in exercise performance and skeletal muscle gene expression [0.03%]
慢性给老鼠使用AICAR可逆转运动表现和骨骼肌基因表达的老化相关变化
Shalene H Wilcox,Jouber Calixto,Steven D Dray et al.
Shalene H Wilcox et al.
Sarcopenia refers to the decline in muscle mass and function that occurs with advancing age. It is driven by alterations in multiple cellular processes. AMP-activated protein kinase (AMPK) is a cellular energy sensor that opposes many age-r...
Potassium channel-mediated NO-induced vasodilation during maturation: Dominance of Kv7 channels [0.03%]
成熟过程中钾通道介导的一氧化氮诱导的血管舒张：Kv7通道占优势
Anastasia A Shvetsova,Dina K Gaynullina,Peter Winkler et al.
Anastasia A Shvetsova et al.
Maturation represents a process characterized by adaptive changes, particularly in the circulatory system. However, it is not known whether, in neonates, potassium channels contribute to NO-induced vasorelaxation at all and, if so, which po...
Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia [0.03%]
维替泊芬通过抑制Hippo信号通路减弱低氧条件下大鼠毛囊神经嵴干细胞的增殖及干性
Weihai Liu,Suhua Chen,Xin Chen et al.
Weihai Liu et al.
Hair follicle neural crest stem cells reside in the bulge region of the outer root sheath of hair follicles, originate from the ectoderm, and have multidirectional differentiation potential, making them ideal candidates for tissue engineeri...
GPCR dimerization: Drug discovery aspects and targets in renin-angiotensin systems [0.03%]
GPCR二聚体化：药物发现的方面及在肾素血管紧张素系统中的靶点
Tahmid Faisal,Tahir Hussain
Tahmid Faisal
G protein-coupled receptors (GPCRs), which play crucial roles in various physiological functions, often assembled into dimers and higher-order oligomers. This oligomerization phenomenon has been observed in diverse physiological and patholo...