Genetic deletion of Alx/Fpr2 differentially regulates pulmonary inflammation in the absence and presence of acute lung injury [0.03%]
遗传缺失Alx/Fpr2在有或没有急性肺损伤的情况下差异调节肺部炎症
Rafia Virk,Madeline Behee,Abrar Al-Shaer et al.
Rafia Virk et al.
The inflammation resolution receptor lipoxin A4/formyl peptide receptor 2 (ALX/FPR2) plays a critical role in immune regulation by binding select oxylipins derived from n-6 and n-3 polyunsaturated fatty acids (PUFAs). While ALX/FPR2 is impl...
Sex differences in donor T cell targeting of host splenocyte subpopulations in acute and chronic murine graft-vs-host disease: results from a novel induction and assessment protocol with implications for lupus-like autoimmunity [0.03%]
小鼠急性移植物抗宿主病和慢性移植物抗宿主病受者脾细胞亚群的性别差异：一项新的诱导及评估方案及其对狼疮样自身免疫的影响结果
Kateryna Soloviova,Charles S Via
Kateryna Soloviova
Using the parent-into-F1 mouse model, we compared in vivo sex differences in acute graft-vs-host (GVHD) disease, a Th1- response and in chronic GVHD, a T follicular helper cell (Tfh) lupus-like antibody response. Using a novel induction pro...
Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into disease pathophysiology [0.03%]
组学发现揭示了高移动性血管病-埃勒斯-丹洛斯综合征病理生理学的见解
Molly Griggs,Victoria Daylor,Taylor Petrucci et al.
Molly Griggs et al.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a poorly understood connective tissue disorder that lacks molecular diagnostic markers. This study aimed to identify proteomic signatures associated with hEDS to define underlying pathophysiology...
Lipid A mimetic BECC438 potentiates durable and balanced antibody responses in an ovalbumin murine model of vaccination [0.03%]
脂质类似物BECC438可增强鸡卵清蛋白小鼠疫苗模型中的长效且平衡的抗体反应
Erin M Harberts,James K Fields,Junela Cecille S Hunat et al.
Erin M Harberts et al.
The need for effective infectious disease vaccines has become an inescapable topic in recent years. Continued development of next-generation vaccines that provide robust protective immunity is imperative. Such vaccines will likely include a...
IL-4 and TGF-β regulate inflammatory cytokines and cellular infiltration in the lung and systemic IL-6 in mouse-adapted SARS-CoV-2 infection [0.03%]
白细胞介素（IL）-4和转化生长因子（TGF）-β调节鼠型SARS-CoV-2感染所致肺部炎症细胞因子及细胞浸润和全身IL-6水平
Solomon Taye Sima,Lucinda Puebla-Clark,Maria Gonzalez-Orozco et al.
Solomon Taye Sima et al.
The pathology of severe COVID-19 is due to a hyperinflammatory immune response persisting after viral clearance. To understand how the immune response to SARS-CoV-2 is regulated to avoid severe COVID-19, we tested relevant immunoregulatory ...
David Allaway,Matt Harrison,Claire Pink et al.
David Allaway et al.
Background: Tseek is a method of sequencing T cell receptor (TCR) repertoires with minimal bias. This work aimed to develop methods to characterize the TCR repertoire in dogs, identify influences such as genetic lineage a...
Exploring MHC class II I-Ab blockade as a potential treatment for Sjögren's disease in the mouse model [0.03%]
探索MHC类II I-Ab阻断作为鼠标模型Sjögren病的潜在疗法
Alexandria Voigt,Shivai Gupta,Yiran Shen et al.
Alexandria Voigt et al.
Sjögren's disease (SjD) is a chronic autoimmune disorder predominantly affecting females, characterized by exocrine gland dysfunction. This study investigates the therapeutic potential of 2-chloro-1-(4-hydroxy-phenyl)-ethanone (CHPE) and m...
Identification of conserved T cell epitopes and flanking amino acid mutants of endogenous retrovirus Gag antigen in nonobese diabetic mice [0.03%]
非肥胖糖尿病小鼠内源性逆转录病毒Gag抗原的T细胞表位及其氨基酸突变体的鉴定
Yang D Dai,Shuhui Li,Amanda Margosiak et al.
Yang D Dai et al.
The interactions between endogenous retroviruses (ERVs) and major histocompatibility complex molecules may significantly influence autoimmune diseases due to their common roles in the evolution and development of the adaptive immune system....
NRF2 agonists 4-octyl-itaconate and dimethyl fumarate reduce human and bovine RSV proliferation and RSV disease in a murine model [0.03%]
NRF2激动剂4-辛基衣康酸和丁苯巴比妥马来酸酯可降低人RSV和牛RSV的增殖并减少小鼠模型中的RSV疾病症状
Fabian E Diaz,Jodi L McGill
Fabian E Diaz
Human and bovine respiratory syncytial virus (RSV) are significant causes of morbidity and mortality in human and cattle populations worldwide, respectively. RSV disease is characterized by deleterious inflammatory immune responses as well ...
The cat's out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense [0.03%]
猫已出袋：托拉普拉斯玛弓形虫为进一步研究髓样介导的宿主防御提供了新见解
Madison L Schanz,Fengdi Zhao,Kamryn E Zadeii et al.
Madison L Schanz et al.
The obligate intracellular protozoan pathogen Toxoplasma gondii is estimated to infect a third of the world's population. Toxoplasmosis is considered a significant worldwide disease that can lead to morbidity or death in immunocompromised i...