Radomir Kratchmarov,Simone A Nish,Wen-Hsuan W Lin et al.
Radomir Kratchmarov et al.
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced an...
Demba Sarr,Caitlin A Cooper,Tara C Bracken et al.
Demba Sarr et al.
Placental malaria, characterized by sequestration of Plasmodium falciparum in the maternal placental blood space and associated inflammatory damage, contributes to poor birth outcomes and ~200,000 infant deaths annually. Specific mechanisms...
Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem) [0.03%]
流行性叶状天疱疮(Fogo Selvagem)中IgG1和IgG4自身抗体特异性不同导致的疾病发展差异
Mike Maldonado,Luis A Diaz,Phillip Prisayanh et al.
Mike Maldonado et al.
We have shown that although the IgG response in fogo selvagem (FS) is mainly restricted to desmoglein (Dsg) 1, other keratinocyte cadherins are also targeted by FS patients and healthy control subjects living in the endemic region of Limão...
Chronic In Vivo Interaction of Dendritic Cells Expressing the Ligand Rae-1ε with NK Cells Impacts NKG2D Expression and Function [0.03%]
表达模式识别受体Rae-1ε的树突状细胞与自然杀伤细胞慢性相互作用影响NKG2D表达和功能
Maelig G Morvan,Marine Champsaur,Boris Reizis et al.
Maelig G Morvan et al.
To investigate how dendritic cells (DCs) interact with NK cells in vivo, we developed a novel mouse model in which Rae-1ε, a ligand of the NKG2D receptor, is expressed in cells with high levels of CD11c. In these CD11c-Rae1 mice, expressio...
Improved therapeutic efficacy of a bifunctional anti-C5 mAb-FH SCR1-5 fusion protein over anti-C5 mAb in an accelerated mouse model of C3 glomerulopathy [0.03%]
在C3系肾小球病加速型小鼠模型中，双功能抗C5mAb-FHSCR1-5融合蛋白比抗C5 mAb具有更好的治疗效果
C3 glomerulopathy (C3G), a rare kidney disease caused by dysregulation of alternative pathway complement activation, is characterized by glomerular C3 deposition, proteinuria, crescentic glomerulonephritis, and renal failure. The anti-C5 mo...