Individuals with latent tuberculosis infection display pulmonary airway enrichment and recall recruitment of CD4+ TRM with protective functional phenotypes [0.03%]
潜伏性结核感染者表现出具有保护功能表型的CD4+TRM肺部气道丰富和再活化招募现象
Jessica R Jarvela,Julie G Burel,Michelle Moyer et al.
Jessica R Jarvela et al.
Tuberculosis (TB) remains a worldwide public health threat, in part because of the limited efficacy of current BCG vaccination. Respiratory infection with Mycobacterium tuberculosis (Mtb) is most often followed by the development of protect...
CD4 and CD8 T-cell response is dominated by IL-10-secreting cells in children with uncomplicated Plasmodium falciparum malaria [0.03%]
单纯感染恶性疟原虫的儿童中CD4和CD8T细胞反应以分泌IL-10的细胞为主
Bonface O Ariera,Bernard Guyah,Ian Onditi et al.
Bonface O Ariera et al.
Plasmodium falciparum malaria and Epstein-Barr virus (EBV) coinfections have been associated with an increased risk of developing the EBV-associated cancer endemic Burkitt lymphoma (eBL). In children living in malaria-endemic areas, repeate...
IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting ACE2-mediated virus binding and cell entry [0.03%]
白细胞介素13通过抑制ACE2介导的病毒结合和细胞进入来保护上皮细胞免受新冠病毒感染
Vadim Pivniouk,Oksana Pivniouk,Jennifer L Uhrlaub et al.
Vadim Pivniouk et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preferentially infects airway epithelial cells. This infection is mediated by the binding of SARS-CoV-2 spike (S) protein to ACE2 expressed on target cells. Patients with allergic...
Polymorphisms in FCN genes and their influence on systemic lupus erythematosus susceptibility: a report from Western India [0.03%]
补体因子H和相关基因多态性与印度西部系统性红斑狼疮易感性的关系研究
Kirti Rai,Ridi Khatri,Amrutha Jose et al.
Kirti Rai et al.
Ficolins, encoded by FCN genes, are key pattern recognition molecules of the lectin complement pathway involved in immune complex clearance, a process often impaired in systemic lupus erythematosus (SLE). Genetic polymorphisms in FCN genes ...
Disrupting the TRAF1/cIAP2 interaction attenuates inflammasome activation and protects against monosodium urate crystal-induced arthritis [0.03%]
干扰TRAF1/cIAP2相互作用可抑制炎性小体活化并预防尿酸晶体诱导的关节炎症
Sahib Singh Madahar,Ali Mirzaesmaeili,Jonathan Raspanti et al.
Sahib Singh Madahar et al.
Tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) regulates NF-κB signaling and is implicated in chronic autoimmune diseases characterized by persistent inflammation. In addition to its role in restraining linear ubiquitin ...
A widely used EYFP-based Cre reporter mouse line fails to detect a significant fraction of Cre+ T cells [0.03%]
一种常用的EYFP基CRE报告小鼠系未能检测出大量CRE+T细胞
Geoffrey S Kansas
Geoffrey S Kansas
The ability to manipulate the mouse genome has contributed heavily to countless discoveries in biology for several decades. The Cre/loxP system enables conditional and inducible deletion of virtually any sequences in the mouse. Because Cre ...
Bonnie N Dittel
Bonnie N Dittel
Stage 1 type 1 diabetes memory B lymphocytes transcriptionally differ from healthy controls and harbor insulin-binding specificities [0.03%]
I型糖尿病患者体内记忆B淋巴细胞的转录特征与健康对照不同，并且能够产生靶向胰岛素的抗体
Lindsay E Bass,Wyatt J McDonnell,Christina T Brannon et al.
Lindsay E Bass et al.
Autoreactive B cell activity defines the earliest detectable stage (Stage 1) of type 1 diabetes (T1D) but is incompletely understood, particularly for B cells reactive against the key T1D autoantigen, insulin. To test whether Stage 1 T1D B ...
Teaching the laboratory assessment of neutrophil chemotaxis: a simulation-based approach for undergraduate immunology [0.03%]
基于模拟的本科免疫学教育中关于中性粒细胞趋化性实验室评估的教学方法
Maurizio Costabile,Gareth Denyer
Maurizio Costabile
Neutrophils are essential cellular components of innate immunity. After injury, they migrate into tissues following chemotactic gradients to phagocytose pathogens or respond to tissue damage. This multistep process is tightly regulated, and...
Normal macrophage signaling and gene expression in Rosa26 Cas9-expressing mice [0.03%]
Rosa26 Cas9小鼠的巨噬细胞信号传导和基因表达正常
Monika D Hermann,Nuria Fernandez Perez,Assa Yeroslaviz et al.
Monika D Hermann et al.
Cas9-expression from the Rosa26 "safe harbor" locus are widely used for gene manipulation and Crispr-based screening. Recently, experimental evidence suggested that macrophages isolated from Rosa26-Cas9 mice may have signaling differences c...