Making multiple comparisons easy: a decision tree and visual statistics guide for data with more than two groups [0.03%]
多种两两比较方法的选择与应用：多组数据的决策树及可视化统计指南
Cody J Gurski,Bonnie N Dittel
Cody J Gurski
Many scientists learn during training to use analysis of variance (ANOVA) when comparing more than 2 groups, yet the principles and follow-up steps are often not well explained. This overview provides a practical guide for selecting appropr...
Interleukin-7R and chemokine receptor type 7 differentially regulate metabolism in CD4+ and CD8+ T cells [0.03%]
CD4+和CD8+T细胞中IL-7R和CCR7对T细胞代谢的调节作用不同
Kimberly A Morrissey,Miriam Valenzuela-Cardenas,Rebekah Gridley et al.
Kimberly A Morrissey et al.
Naïve T cells are highly metabolically active, maintaining homeostatic function as well as continuously moving and surveying lymph nodes for dendritic cells (DCs) presenting cognate antigen. T-cell metabolism is thought to change throughou...
Grace Turyasingura,Kagan A Mellencamp,Ruth Namazzi et al.
Grace Turyasingura et al.
Memory-like natural killer (NK) cells with enhanced antibody-dependent cellular cytotoxicity (ADCC) have correlated with protection from uncomplicated malaria in prior studies. However, the role of NK cells in severe malaria (SM) has not be...
Harnessing the microbiome to regulate myeloid TREM2 expression and innate immune responses [0.03%]
利用微生物组调节髓系TREM2表达和固有免疫反应
Saki Mihori,Frank C Nichols,Evan R Jellison et al.
Saki Mihori et al.
The composition of the gastrointestinal microbiome is correlated with numerous immune-mediated systemic diseases, but underlying mechanisms remain unclear. In murine studies, we recently identified microbiome Bacteroidota-derived bacterial ...
Guangbo Bill Chen,Ashley Smith,Joel Lee et al.
Guangbo Bill Chen et al.
The development of effective vaccines against emerging infectious diseases, including avian influenza strains such as H5N1 and H7N9, is hindered by the limited translational fidelity of animal models and the low throughput of traditional pr...
Immunological and virological questions for H5N1 pandemic emergence [0.03%]
H5N1病毒引发大流行所需解决的免疫学和病毒学问题分析
Mario A Peña-Hernández,Miyu Moriyama
Mario A Peña-Hernández
Zoonotic spillover of influenza A viruses into humans has repeatedly triggered pandemics throughout history. Since their emergence in the 1990s, H5N1 influenza viruses have significantly expanded their geographical range and host species, r...
Highly pathogenic avian influenza: a One Health perspective on risks, surveillance, and resilience [0.03%]
高致病性禽流感：关于风险、监测和应对能力的“同一个健康”观点
Timothy N Chou,Elena N Naumova,Jonathon D Gass Jr
Timothy N Chou
Highly pathogenic avian influenza (HPAI) poses an expanding global threat with direct relevance to immunologists studying host-pathogen dynamics, cross-species transmission, and immune responses to emerging viruses. Driven primarily by evol...
BRCA1 deficiency leads to aberrant epithelial differentiation in the thymus [0.03%]
BRCA1缺陷导致胸腺上皮细胞分化异常
Chikako Odaka,Marieke van de Ven,Panagiota Sotiropoulou et al.
Chikako Odaka et al.
BRCA1 (breast cancer 1, early onset) is originally identified as a tumor suppressor in hereditary breast and ovarian cancer. Recent studies have suggested that BRCA1 contributes to the cell fate decisions in mammary epithelium. Although BRC...
Rapid decline of SARS-CoV-2-specific salivary IgA antibody levels in people with hybrid immunity-data from the STOPCoV study [0.03%]
来自STOPCoV研究的具有混合免疫的人群中SARS-CoV-2特异性唾液IgA抗体水平快速下降的数据
Sharon L Walmsley,Majid Nabipoor,Gary Chao et al.
Sharon L Walmsley et al.
Hybrid immune individuals who experience an infection after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine series show evidence of salivary anti-spike and anti-receptor binding domain (RBD) IgA antibodies with b...
Preceding influenza infection impacts neutrophil response to Aspergillus fumigatus and Staphylococcus aureus [0.03%]
流感病毒感染影响中性粒细胞对烟曲霉和金黄色葡萄球菌的反应
Nima Naghshtabrizi,Kara L Nickolich,Ravineel B Singh et al.
Nima Naghshtabrizi et al.
Influenza infection predisposes individuals to secondary pneumonia caused by a range of pathogens, including both bacterial and fungal organisms. Neutrophils are critical effector cells during infection. In this study, we analyzed the trans...