Longitudinal profiling of antigen receptor gene repertoire dynamics in kidney transplant recipients after multiple SARS-CoV-2 vaccinations [0.03%]
肾脏移植受者多次接种 SARSCoV2 疫苗后的抗原受体基因谱系动态纵向分析
Antonios Mingos,Nikolaos Pechlivanis,Georgios Karakatsoulis et al.
Antonios Mingos et al.
Kidney transplant recipients (KTRs) exhibit impaired immune responses to vaccination against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, remaining vulnerable to severe coronavirus disease 2019 (COVID-19) even aft...
Macrophages in human atherosclerotic plaques in the era of single-cell and spatial transcriptomics [0.03%]
单细胞和空间转录组学时代的人类动脉粥样硬化斑块巨噬细胞
Adil Ijaz,Adil Rasheed,Marco Orecchioni
Adil Ijaz
Macrophages are central players of inflammation, lipid metabolism, and remodeling in atherosclerotic plaques. Historically simplified into "M1" and "M2" polarization states, their biology has been fundamentally redefined by single-cell and ...
A method to unravel complexity in human peripheral blood B-cell subsets through multiomic cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analyses [0.03%]
通过转录组和表位测序(CITE-seq)分析解析人类外周血B细胞亚群复杂性的一种方法
Nathan J Meinhardt,Anthony J Veltri,Cody J Gurski et al.
Nathan J Meinhardt et al.
Classifying heterogeneous human B cells into discrete subsets based on surface phenotype alone remains a major challenge. We discovered a mouse splenic IgM+IgDlow/- B-cell subset (BDL) that induces proliferation of CD4+Foxp3+ T regulatory c...
Consequences of the perivascular niche remodeling for tumoricidal T-cell trafficking into metastasis of ovarian cancer [0.03%]
肿瘤血管周围生态龛重塑对杀伤性T细胞进入卵巢癌转移灶的影响
Marta Winkler,Nemi Malhotra,Anna Mistarz et al.
Marta Winkler et al.
Aberrant angiogenesis in ovarian cancer (OC), driven by excessive vascular endothelial growth factor (VEGF) and other proangiogenic mediators, gives rise to structurally and functionally abnormal tumor vasculature that hinders effective T-c...
Delineation of the antibody light chain biases and kinetics following primary and secondary influenza virus infections of ferrets [0.03%]
划定经过初次和再次流感病毒感染的雪貂中的抗体轻链偏差和动力学
Robert A Richardson,Thomas Rowe,Greg A Kirchenbaum et al.
Robert A Richardson et al.
The ferret is considered the "gold standard" animal model for influenza virus research. However, the mechanisms of the ferret humoral immune responses remain understudied. Here, the kinetic profile of the influenza A or B virus hemagglutini...
Peptide-adaptive NK cell memory in the absence of functional TCR genes [0.03%]
缺乏功能性TCR基因的肽适应性NK细胞记忆
Safyha Bryan,Gayani S Gamage,Sayanti Dey et al.
Safyha Bryan et al.
Natural killer (NK) cells are a key component of the innate immune system and are specialized in the recognition and elimination of virally infected, tumor, and otherwise abnormal cells. However, multiple laboratories have shown that NK cel...
The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T-cell generation [0.03%]
孤儿核受体NR4A3对驻留记忆CD8⁺T细胞的发生是可有可无的
Livia Odagiu,Salix Boulet,Dave Maurice De Sousa et al.
Livia Odagiu et al.
Different memory CD8+ T-cell subsets are generated following acute responses: central, effector and resident (Trm). CD8+ Trm cells established residency at the sites of infection and provide an efficient and rapid frontline defense against ...
Potential CD27-CD70 interaction within adoptive T cells does not affect tumor antigen-specific T-cell immunotherapy [0.03%]
供体T细胞中CD27-CD70相互作用对肿瘤特异性过继性免疫治疗的影响较小
Eswara Rao Puppala,Mohammad A Alzubi,Habeebat Aderonke Mustapha et al.
Eswara Rao Puppala et al.
The CD27-CD70 pathway regulates T-cell activity either positively or negatively depending on the context of immune response. Typically, CD27 is known as a co-stimulatory receptor expressed on T cells while CD70 is the ligand expressed on an...
Michael C McGee,Wei Luo,Weishan Huang
Michael C McGee
Viral infections induce heterogeneous memory T and B cell populations that may rapidly recall and provide protection against re-infection. The immunomodulatory cytokine interleukin-10 (IL-10) is well described for its role in restricting im...
Expression of ultralong complementarity determining region 3 and development of IgM and IgG B cell receptor repertoires in Holstein heifer calves [0.03%]
超长补体决定区3的表达与黑白花牛犊IgM和IgG B细胞受体 repertoire的发展
Tess E Altvater-Hughes,Harold P Hodgins,Douglas C Hodgins et al.
Tess E Altvater-Hughes et al.
There are currently knowledge gaps regarding the development of the bovine B cell repertoire especially for cells expressing B cell receptors with heavy chain ultralong complementarity determining region 3 (CDR3). The objective of this stud...