STAT6-IP-dependent inhibition of type 2 innate and Th2 adaptive immunity in the murine lung [0.03%]
Stat6依赖的抑制小鼠肺部的2型先天性和Th2适应性免疫反应
Haya Aldossary,Rami Karkout,Véronique Gaudreault et al.
Haya Aldossary et al.
Type 2 airway inflammation is one of the main characteristics of allergen-induced asthma. Evidence from animal studies supports a model in which inhalation of allergens triggers epithelial cell release of alarmin cytokines, including IL-33,...
Direct contact with natural killer cells reprograms monocyte-derived dendritic cells into a tolerogenic phenotype [0.03%]
直接接触的自然杀伤细胞可将单核细胞源树突状细胞重编程为耐受表型
Ammar J Alsheikh,Liang Chen,Daniel Korenfeld et al.
Ammar J Alsheikh et al.
Tissue-infiltrating monocyte-derived dendritic cells (DCs) and macrophages are key antigen-presenting cells promoting inflammation and tissue damage by releasing proinflammatory cytokines and strongly activating T cells. These antigen-prese...
Revealing the immune landscape of menstrual blood: unlocking insights into activation, exhaustion, and mitochondrial mass for reproductive health [0.03%]
揭秘月经血的免疫图谱：揭示生殖健康中的激活、耗竭和线粒体质量的见解
Oliver Richards,Megan Cotterell,Catherine A Thornton et al.
Oliver Richards et al.
Reproductive disorders such as endometriosis and polycystic ovary syndrome (PCOS) are increasingly recognized as immune-mediated conditions, yet their immunopathology remains poorly understood. Menstrual blood, a noninvasive and biologicall...
Fine tuning of TCR signaling via CD8αβ and PD-1 and the fate of autoreactive thymocytes during negative selection [0.03%]
CD8αβ和PD-1调节TCR信号通路以及负向选择过程中自身反应性胸腺细胞的命运走向
Martha C Zúñiga,Sangwon Hyun,Jacob Du et al.
Martha C Zúñiga et al.
During thymocyte development, positive selection produces cells whose T cell receptors (TCRs) bind to self MHC. Then, negative selection culls most thymocytes whose TCRs have too high an affinity for self MHC+peptide. Signal transduction ev...
Respiratory syncytial virus mRNA vaccine-induced immunity and protection against subgroups A and B in mice [0.03%]
人呼吸道合胞病毒mRNA疫苗诱导的免疫应答及其对鼠A亚群和B亚群的保护作用
Sujin Lee,Jack Yoon,Savannah Shooter et al.
Sujin Lee et al.
Respiratory syncytial virus (RSV) is a major global cause of severe lower respiratory tract infections in infants and older adults. RSV has 2 subgroups, A (RSV-A) and B (RSV-B), which circulate together with different patterns of dominance....
Phenotypically similar but functionally distinct NK cell populations within the human maternal-fetal interface [0.03%]
功能各异但表型相似的人类母胎界面自然杀伤细胞群
Marie Frutoso,Caitlin S DeJong,Raj Shree et al.
Marie Frutoso et al.
Natural killer (NK) cell function within tissues extends beyond exerting cytotoxicity, encompassing a range of functions that are just starting to become fully elucidated. In the context of human placentation, NK cells play a key role in en...
Macrophage efferocytosis in cardiovascular disease: mechanisms and therapeutic implications [0.03%]
巨噬细胞在心血管疾病中的凋亡细胞吞噬作用：机制及治疗意义
Neha Gupta,Yu Liu,Bishuang Cai
Neha Gupta
Cardiovascular diseases (CVDs) account for millions of deaths worldwide each year, underlining their significant impact on global health. An expanding body of evidence identifies atherosclerosis, myocardial infarction, heart failure, and is...
Cardiac macrophages at the crossroads of inflammation, memory, and repair [0.03%]
处于炎症、记忆和修复十字路口的心肌巨噬细胞
Yiliang Chen
Yiliang Chen
Sustained monocyte activation by persistent challenges with either oxLDL or free cholesterol and underlying mechanisms [0.03%]
氧化型低密度脂蛋白或游离胆固醇持续刺激单核细胞活化及其作用机制
Yajun Wu,Shuo Geng,Grace Atkinson et al.
Yajun Wu et al.
Chronic low-grade inflammation is a hallmark of atherosclerosis and cardiovascular diseases, with monocytes playing a central role in sustaining this pathological state. In this study, we demonstrate that prolonged exposure to oxidized low-...
Trained immunity: new paradigm in the immunological memory of cardiovascular disease [0.03%]
训练免疫：心血管疾病免疫记忆的新范式
Emma Hope,Azuah L Gonzalez,Lola S Norman et al.
Emma Hope et al.
Cardiovascular disease (CVD) remains the leading cause of death worldwide, despite significant progress in identifying and managing traditional risk factors such as hyperlipidemia, hypertension, and diabetes. While targeted therapies addres...