Lack of pathogenic involvement of CCL4 and its receptor CCR5 in arthritogenic alphavirus disease [0.03%]
CCL4及其受体CCR5不参与致关节炎性α病毒病的发病机制
Muddassar Hameed,Norman A Solomon,James Weger-Lucarelli
Muddassar Hameed
Arthritogenic alphaviruses, including chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong virus (ONNV), are emerging and reemerging viruses that cause disease characterized by fever, rash, and incapacitating muscle and j...
Efficacy and safety of acalabrutinib with best supportive care versus best supportive care in patients with COVID-19 requiring hospitalization [0.03%]
阿卡布替尼联合最佳支持治疗与单独最佳支持治疗对比住院的COVID-19患者的疗效和安全性
Phillip Scheinberg,Matt R Khoshnevis,Philip A Robinson et al.
Phillip Scheinberg et al.
The efficacy and safety of acalabrutinib, a Bruton tyrosine kinase (BTK) inhibitor, was evaluated in 2 phase 2 studies in hospitalized patients with coronavirus disease 2019 (COVID-19) who received acalabrutinib + best supportive care (BSC)...
Clinical Trial
ImmunoHorizons. 2025 May 30;9(7):vlaf023. DOI:10.1093/immhor/vlaf023 2025
Characterization of IgE cross-reactivity and allergenicity of peanut allergens [0.03%]
花生过敏原的IgE交叉反应表征及其致敏性
Christian Lapitan,William R Zhang,Beichu Guo et al.
Christian Lapitan et al.
IgE cross-reactivity among peanut allergens is controversial, and allergenicity of peanut allergens other than Arachis hypogaea 2 [Ara h 2] remains to be elucidated. We investigated the origins of peanut IgE cross-reactivity using Western b...
Dynamics of antimicrobial proteins' expression and their bactericidal activity in mouse milk [0.03%]
小鼠乳汁中抗菌蛋白质的表达动态及其杀菌活性
Piu Saha,Ahmed Abokor,Matam Vijay-Kumar
Piu Saha
Mother's milk is considered as "complete edible immune system." It contains macro- and micronutrients required to maintain infant growth and provides an excellent source for innate and adaptive immune proteins that not only protects infants...
Correction to: Comprehensive immune profiling of dengue and chikungunya viral responses using a novel miniaturized automated whole blood cellular analysis system and mass cytometry in a pediatric cohort in Msambweni, Kenya [0.03%]
肯尼亚Msambweni儿科群体中登革热和奇昆古雅病毒免疫反应综合免疫谱分析的修正：采用一种新型微型化自动全血细胞分析系统及质谱细胞术
Published Erratum
ImmunoHorizons. 2025 Apr 26;9(6):vlaf020. DOI:10.1093/immhor/vlaf020 2025
PTEN inhibits scavenger receptor-mediated phagocytosis of methicillin-resistant Staphylococcus aureus [0.03%]
磷脂张力蛋白(PTEN)通过抑制摄取甲氧西林耐药金黄色葡萄球菌的模式受体介导吞噬作用从而发挥抗菌作用
Eden E Faneuff,Min Joo Kim,Amondrea Blackman et al.
Eden E Faneuff et al.
Phagocytosis requires the coordination of various classes of receptors and the activation of multiple signaling programs, culminating in actin cytoskeletal rearrangement and ingestion. Given the pleiotropic nature of the events necessary fo...
STAP-1-derived peptide suppresses TCR-mediated T cell activation and ameliorates immune diseases by inhibiting STAP-1-LCK binding [0.03%]
STAP-1衍生肽通过抑制STAP-1-LCK结合来抑制TCR介导的T细胞活化并改善免疫疾病
Yuto Sasaki,Kota Kagohashi,Shoya Kawahara et al.
Yuto Sasaki et al.
Signal-transducing adaptor protein-1 (STAP-1) is an adaptor protein specifically expressed in immune cells, such as T cells. We previously demonstrated that STAP-1 positively upregulates T cell receptor (TCR)-mediated T cell activation by i...
Identification and characterization of tissue resident memory T cells in malignant pleural effusions associated with non-small cell lung cancer [0.03%]
非小细胞肺癌相关恶性胸腔积液中的组织驻留记忆T细胞的鉴定和表征
Caitlin M Tilsed,Joshua Brotman,Shaun O&#x;Brien et al.
Caitlin M Tilsed et al.
Tissue resident memory T cells (TRM) play a critical role in cancer immunity and their presence in solid tumors is associated with improved prognosis and response to therapy. Although TRM have been identified and their function characterize...
Characterizing TLR4 agonist EmT4™ as an anti-Mycobacterium tuberculosis vaccine adjuvant [0.03%]
表征TLR4激动剂EmT4作为抗分枝杆菌疫苗佐剂的作用机制
Sasha E Larsen,Maham Rais,Valerie A Reese et al.
Sasha E Larsen et al.
Tuberculosis (TB) is again the deadliest infectious disease globally, and more efficacious vaccines are needed to reduce this mortality. Successful subunit TB vaccines need antigens and adjuvants that are immunogenic, inexpensive, and acces...
Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge [0.03%]
微生物组介导的小鼠恶性疟原虫Yoelii17X免疫记忆的调节会影响对继发性脑型疟疾感染的抵抗力
Elizabeth M Fusco,Layne Bower,Rafael Polidoro et al.
Elizabeth M Fusco et al.
Malaria is caused by protozoan parasites in the genus Plasmodium. Over time individuals slowly develop clinical immunity to malaria, but this process occurs at variable rates, and the mechanism of protection is not fully understood. We have...