Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One-Sample Mendelian Randomization Study [0.03%]
人类巨细胞病毒感染与慢性背痛因果关系的单样本孟德尔随机化研究证据
Maryam Kazemi Naeini,Maxim B Freidin,Isabelle Granville Smith et al.
Maryam Kazemi Naeini et al.
Background: Chronic back pain (CBP) is a major cause of disability globally. While its etiology is multifactorial, specific contributing genetic and environmental factors remain to be discovered. Paraspinal muscle fat has...
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks [0.03%]
老年小鼠椎间盘巨噬细胞变化及高通量测序分析
Wei Wang,Cheng Jiang,Jiong-Hui Chen et al.
Wei Wang et al.
Background: Intervertebral disk (IVD) degeneration is associated with lower back pain and aging; however, the mechanisms underlying age-related changes and the changes in macrophage polarization in aging intervertebral di...
Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor-Related Gene Analysis [0.03%]
基于转录因子相关基因分析的椎间盘退变纤维环分子亚型及免疫微环境特征解析
Sikuan Zheng,Xiaokun Zhao,Hui Wu et al.
Sikuan Zheng et al.
Objective: This study aims to examine the role of translation factors (TF) in intervertebral disc degeneration (IVDD) and to evaluate their clinical relevance through unsupervised clustering methods. ...
Phosphatidylcholine Ameliorates Palmitic Acid-Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration [0.03%]
磷脂酰胆碱通过促进内质网和线粒体的相互作用缓解棕榈酸诱导的脂毒性以治疗椎间盘退变
Shuangshuang Tu,Yijun Dong,Chuanfu Li et al.
Shuangshuang Tu et al.
Background: Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal disorder with substantial socioeconomic impacts. Despite its high prevalence, the pathogenesis of IDD remains unclear, and effective pharma...
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique [0.03%]
基于网络毒理学和分子对接技术的尼古丁毒性及细胞衰老机制分析研究 nucleus pulposus 细胞中的
Chen Jiang,Chao Song,Chaoqi Chen et al.
Chen Jiang et al.
Aim: Through the use of network toxicology, the research sought to determine whether cellular senescence and associated molecular mechanisms in nicotine-induced intervertebral disc degeneration (IVDD) were potentially har...
The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration [0.03%]
MAPK信号通路在椎间盘退变的诊断和分型中的意义
Yong Liu,Xueyan Chen,Jingwen Chen et al.
Yong Liu et al.
Background: Intervertebral disc degeneration (IDD) is a human aging disease related mainly to inflammation, cellular senescence, RNA/DNA methylation, and ECM. The mitogen-activated protein kinase (MAPK) signaling pathway ...
Transcriptome Data Combined With Mendelian Randomization Analysis Identifies Key Genes Associated With Mitochondria and Programmed Cell Death in Intervertebral Disc Degeneration [0.03%]
转录组数据结合孟德尔随机分析鉴定与椎间盘退变中线粒体和程序性细胞死亡相关的基因
Hongfei Nie,Xiao Hu,Jiaxiao Wang et al.
Hongfei Nie et al.
Background: Intervertebral disc degeneration (IDD) is a major cause of cervical and lumbar diseases, significantly impacting patients' quality of life. Mitochondria and cell death have been implicated in IDD, but the key ...
Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue Such as Intervertebral Disc Using QuPath [0.03%]
QuPath用于间盘等细胞成分少的组织免疫组化染色切片的半自动定量分析及验证
Andrea Nüesch,Maria Paola Ferri,Christine L Le Maitre
Andrea Nüesch
Background: Immunohistochemistry (IHC) is a widely used method for localizing and semi-quantifying proteins in tissue samples. Traditional IHC analysis often relies on manually counting 200 cells within a designated area,...
The Significance of Cellular Senescence Hub Genes in the Diagnosis and Subtype Classification of a Comprehensive Database of Gene Expression in Intervertebral Disc Degeneration [0.03%]
细胞衰老中心基因在椎间盘退变综合基因表达数据库的诊断和亚型分类中的意义
Fei Liu,Silong Gao,Ji Yin et al.
Fei Liu et al.
Background: Intervertebral disc degeneration (IVDD) is a complex age-related physiological process, with cellular senescence (CS) being a primary contributing factor. However, the precise role of CS and its associated gen...
DeVa (Decay Variance): A Novel Score Calculated via Postprocessing the Changes in Signal Intensity of an Intervertebral Disc in a T2* Multi-Echo Magnetic Resonance Image Can Quantify Painful and Degenerate Lumbar Vertebral Discs [0.03%]
通过后处理T2*多回波磁共振成像中椎间盘信号强度的变化，计算的一种新得分（衰减方差DeVa）可以量化疼痛性退化腰椎间盘
Stone Sima,Alisha Sial,Suhani Sharma et al.
Stone Sima et al.
Introduction: Low back pain (LBP), a global disability leader, is often linked to intervertebral disc (IVD) degeneration. Traditional diagnostics like T2-weighted MRI provide qualitative but imprecise evaluations. A novel...