An Extracellular Matrix Hydrogel Restores Disc Volume and Alleviates Axial Hypersensitivity in a Rat Model of Disc-Associated Pain [0.03%]
一种细胞外基质水凝胶可恢复椎间盘体积并缓解疼痛模型中的轴向过敏反应
David J Lillyman,Evie C Reddick,Kayla E Ney et al.
David J Lillyman et al.
Background: Chronic low back pain is a global socioeconomic crisis, and the majority of those treated for this condition fail to reach long-term remission. Intervertebral disc degeneration is the predominant associative f...
Jeffrey L Hutchinson,Amalie J Hutchinson,Joy Feng et al.
Jeffrey L Hutchinson et al.
Background: The use of sex hormones in the clinic for the management of musculoskeletal conditions is increasingly common. Despite this, the role of sex hormones in various joint tissues such as the intervertebral disc (I...
Correction to "Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions" [0.03%]
对“椎体骨髓病变慢性腰痛患者的肠道菌群和代谢组变化”的更正
[This corrects the article DOI: 10.1002/jsp2.70042.]. © 2025 The Author(s). JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Resear...
Published Erratum
JOR spine. 2025 May 15;8(2):e70074. DOI:10.1002/jsp2.70074 2025
Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear-Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes [0.03%]
校正人口统计学、恐惧避免信念、失眠和脊柱退行性改变后慢性特发性腰背痛患者的腰背部多裂肌形态与疼痛/功能障碍之间的关系
Sabina M Pinto,Jason P Y Cheung,Dino Samartzis et al.
Sabina M Pinto et al.
Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as ...
Intervertebral Lumbar Spine Kinematics in Chronic Low Back Pain Patients Measured Using Biplane Radiography [0.03%]
双平面放射成像测量的慢性下背痛患者的腰椎间盘腰椎运动学
William Anderst,C James Kim,Kevin M Bell et al.
William Anderst et al.
Background: Chronic low back pain (cLBP) presents as a heterogeneous condition, making diagnosis and treatment challenging. Lumbar spine intervertebral kinematics may provide an objective assessment of patients with cLBP ...
Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration [0.03%]
椎间盘退变中巨噬细胞极化的机制及治疗策略
Kaiyuan Zheng,Siyu Wang,Meng Deng et al.
Kaiyuan Zheng et al.
Background: Intervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP), contributing significantly to global disability and productivity loss. Its pathogenesis involves complex processes, including ...
Human Disc Degeneration Is Accompanied by a Loss of Anterior Annulus Fibrosus Interlamellar Matrix Integrity as Assessed by Peel Tests [0.03%]
人腰椎间盘退变伴腹侧纤维环髓核间板基质完整性下降（基于剥除试验判断）
Manmeet S Dhiman,Mohammed A Salaam,Taylor J Bader et al.
Manmeet S Dhiman et al.
Introduction: Disc degeneration (DD) is accompanied by biomechanical changes in the intervertebral discs. The lamellae of the annulus fibrosus (AF) are interconnected through the interlamellar matrix (ILM). The ILM contai...
Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress-Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy [0.03%]
磷脂酰乙醇胺通过促进自噬保护椎间盘细胞免受氧化应激诱导的衰老和细胞外基质降解
Yijun Dong,Chuanfu Li,Shuangshuang Tu et al.
Yijun Dong et al.
Background: Intervertebral disc degeneration (IDD) is a type of musculoskeletal system diseases that prevail widely in human society, exerting a substantial economic burden on society. The extensive aggregation of senesce...
Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging-Based Subject-Specific Musculoskeletal Models [0.03%]
基于影像的脊柱负荷估算学科特异性肌骨模型的相关生理和人体测量学因素
Brett T Allaire,Fjola Johannesdottir,Mary L Bouxsein et al.
Brett T Allaire et al.
Background: Subject-specific musculoskeletal models may be used to estimate spine loads that cannot be measured in vivo. Model generation methods may use detailed measurements extracted from medical imaging, but it may be...
Identification and Validation of Circadian Rhythm-Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning [0.03%]
基于机器学习的节律相关基因在椎间盘退变中作用及免疫细胞浸润分析
Yongbo Zhang,Liuyang Chen,Sheng Yang et al.
Yongbo Zhang et al.
Background: Low back pain is a significant burden worldwide, and intervertebral disc degeneration (IVDD) is identified as the primary cause. Recent research has emphasized the significant role of circadian rhythms (CRs) a...