Unveiling the Potential Mechanism of Asymmetric Fat Infiltration in Paraspinal Muscles of Adult Degenerative Scoliosis: The Role of the Hsa_circ_0006156/miR-122-5p/PPARA Regulatory Network [0.03%]
成人退变性侧弯腰背肌不对称脂肪浸润潜在机制的揭示：Hsa_circ_0006156/miR-122-5p/PPARA调控轴的作用
Xueneng Yang,Limin Guo,Jun Shu
Xueneng Yang
Background: Paraspinal muscle degeneration, particularly fat infiltration, is a prominent feature of adult degenerative scoliosis (ADS), which impairs spinal stability, accelerates disease progression, and contributes to ...
An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell-Based Grafts [0.03%]
一种评估细胞基底移植体内保留性的椎间盘退变的体外模型
Raphael Schmid,Janhavi Apte,Elias Schulze et al.
Raphael Schmid et al.
Introduction: Cell therapies for painful intervertebral disc (IVD) degeneration (IDD) have not yet achieved widespread clinical adoption. Understanding therapeutic cell effects in native IVD remains challenging due to the...
Evaluation of Lumbar Intervertebral Disc and Facet Joint Degeneration Using Histogram Analysis of T2 and T2* Values [0.03%]
基于T2和T2*弛豫时间直方图分析评估腰椎间盘与小关节的退变
Xiaoqing Liang,Yitong Li,Bowen Hou et al.
Xiaoqing Liang et al.
Background: Lumbar facet joint (LFJ) and intervertebral disc (IVD) degeneration are the common causes of low back pain. The aim of this study is to explore the feasibility of histogram analysis of T2 and T2* values on gra...
Meta-Analysis of the Application Value of Metagenomic Next-Generation Sequencing Technology in the Diagnosis of Infectious Diseases of the Spine [0.03%]
宏基因组二代测序技术在脊柱感染性疾病诊断中应用价值的 meta 分析
Xuejiu Cai,Honglei Yi,Kun Chen et al.
Xuejiu Cai et al.
Objective: To evaluate the diagnostic efficacy of metagenomic next-generation sequencing (mNGS) in infectious diseases of the spine (IDS). Methods: ...
Intracellular Detection of C. acnes and S. aureus in Non-Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways [0.03%]
健康人椎间盘中不动杆菌和金黄色葡萄球菌的细胞内检测：对分解代谢信号通路的意义
Andrea Nüesch,Exarchos Kanelis,Leonidas G Alexopoulos et al.
Andrea Nüesch et al.
Objective: To investigate whether the presence of bacteria within non-herniated intervertebral discs (IVDs) represents bacterial antigen signals within disc cell boundaries, consistent with in vivo presence and to assess ...
Therapeutic Approaches for Enhancing Spinal Fusion in Low Back Pain: A Review With a Focus on the Elderly [0.03%]
改善老年人腰背痛脊柱融合的治疗策略：综述
Shuimu Chen,Zhen Li,Sebastian F Bigdon et al.
Shuimu Chen et al.
Background: Low back pain (LBP) is a prevalent cause of disability worldwide, particularly among the elderly, with degenerative spinal conditions often necessitating surgical intervention. Spinal fusion remains a definiti...
Lovastatin-Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle-Puncture Induced Degeneration Model in Rat Caudal Discs [0.03%]
载洛伐他汀纳米粒的热敏性壳聚糖水凝胶缓释系统治疗椎间盘退变：体外细胞培养研究及大鼠尾部椎间盘穿刺诱导退变模型体内评价
Chih-Wei Chen,Yung-Hsin Cheng,Kai-Chiang Yang et al.
Chih-Wei Chen et al.
Background: Sustained release of therapeutic factors, such as lovastatin, is theoretically more beneficial than a single injection in promoting anabolic stimulation to nucleus pulposus cells/tissues. This study aimed to d...
PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis [0.03%]
PIEZO1-主纤毛轴介导了特发性青少年脊柱侧凸生长板退变和骨化中的压缩应力反应
Fei Chen,Shuqing Chen,Fushuai Peng et al.
Fei Chen et al.
Background: Adolescent idiopathic scoliosis (AIS) is linked to mechanical stress-induced growth plate dysfunction. PIEZO1 (mechanosensitive ion channel) mediates chondrocyte apoptosis via calcium, and primary cilia (mecha...
Beyond the Curve: The Muscle-Specific Asymmetries of Adolescent Idiopathic Scoliosis [0.03%]
青少年特发性脊柱侧弯的肌肉不对称超越了曲线模式
Phoebe Duncombe,Taylor Dick,Phoebe T T Ng et al.
Phoebe Duncombe et al.
Background: Adolescent idiopathic scoliosis (AIS) describes an asymmetrical formation of the spine that develops rapidly during adolescence. It is well known that the forces applied to bones, such as from paraspinal muscl...
The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho-Anatomical Studies: A Historical Perspective [0.03%]
羊环形病变模型对椎间盘病理生物学的影响以及羊脊柱模型在病理解剖学研究中的作用：历史回顾
O Osti,C B Little,J Melrose
O Osti
This review documents the impact of the Osti ovine annular lesion model of intervertebral disc (IVD) degeneration on the elucidation of degenerative changes in the ovine IVD also seen in human IVD degeneration (IVDD). The degenerative patho...