Human Placental Extract as a Promising Epidural Therapy for Lumbar Spinal Stenosis: Enhancing Axonal Plasticity and Mitigating Pain and Inflammation in a Rat Model [0.03%]
人类胎盘提取物作为治疗腰椎管狭窄症的硬膜外疗法的前景：在大鼠模型中增强轴突可塑性并减轻疼痛和炎症
Jin Young Hong,Hyun Kim,Wan-Jin Jeon et al.
Jin Young Hong et al.
Background: Epidural injections treat lumbar spinal stenosis (LSS) by targeting localized inflammation and tissue damage. However, current medications such as corticosteroids and local anesthetics often have limited effic...
Complex In Vivo Motion of the Bovine Tail Provides Unique Insights Into Intervertebral Disc Adaptation [0.03%]
牛尾巴的复杂体内运动为椎间盘适应提供了独特的见解
Arthur J Michalek,Isabelle M Wood,Daniela Gonzalez Carranza et al.
Arthur J Michalek et al.
Introduction: The intervertebral disc (IVD) of the bovine tail is a commonly used research analogue for the human disc at the organ, tissue, and cellular levels. While these tails are subjected to thousands of dynamic mot...
Injection Volume Is a Better Predictor of Stiffness Restoration Than Injection Force in an In Vitro Study of Nucleus Augmentation of the Intervertebral Disc [0.03%]
一项椎间盘髓核增强的体外研究显示注射体积比注射力更能预测椎间盘僵硬度的恢复
J P Warren,A R Dixon,M P Culbert et al.
J P Warren et al.
Purpose: Nucleus augmentation has been proposed as an early-stage intervention for intervertebral disc degeneration and involves the injection of a biomaterial into the nucleus to restore disc height and functionality. Th...
Jake M McDonnell,Stacey Darwish,Joseph S Butler et al.
Jake M McDonnell et al.
Background: Adipokines are bioactive molecules secreted by adipose tissue that influence both local and systemic physiological processes. Although adipokine dysregulation has been widely implicated in the pathogenesis of ...
Intradiscal Mesenchymal Stromal Cell Therapy for the Treatment of Low Back Pain Due to Moderate-to-Advanced Multilevel Disc Degeneration: A Preliminary Report of a Double-Blind, Phase IIB Randomized Clinical Trial (DREAM Study) [0.03%]
自体间充质干细胞治疗多节段椎间盘中重度退变所致慢性下腰痛的临床疗效观察：双盲随机对照IIB期临床试验（梦幻研究）初步报告
Gianluca Vadalà,Fabrizio Russo,Cristiana Lavazza et al.
Gianluca Vadalà et al.
Background: Low back pain (LBP) is a leading cause of disability worldwide, often associated with intervertebral disc degeneration (IDD). Mesenchymal stromal cells (MSCs) have emerged as a promising regenerative therapy f...
Crosstalk Between Ferroptosis and Cuproptosis in Intervertebral Disc Degeneration: Mechanisms, Therapeutic Targets, and Future Directions [0.03%]
铁死亡和铜死亡在椎间盘退变中的交叉对话：机制、治疗靶点及未来方向
Zhongpan Li,Liangwei Wang,Xiaojun Wu et al.
Zhongpan Li et al.
Background: Intervertebral disc degeneration (IVDD) is a prevalent degenerative disease, with low back pain as its primary clinical symptom, imposing significant burdens on individuals and society. With the aging populati...
Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two-Step, Two-Sample Bidirectional Mendelian Randomization Study [0.03%]
肠道微生物与代谢物和椎间盘退变之间的因果关系：两步、两样本双向孟德尔随机化研究
Yi-Ping Zheng,Dong-Lin Yang,Lu-Yang Wang et al.
Yi-Ping Zheng et al.
Background: Some studies have shown that gut microbiota may be associated with intervertebral disc degeneration. However, the causal effects between gut microbiota and IVDD and whether blood metabolites act as a mediator ...
In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration [0.03%]
活体测量显示乳酸和氧浓度在椎间盘退变山羊模型的髓核中升高
Karthikeyan Rajagopal,Thomas P Schaer,Kyle D Meadows et al.
Karthikeyan Rajagopal et al.
Introduction: Intervertebral disc degeneration is strongly implicated as a cause of low back pain. Although the precise pathophysiological mechanisms remain elusive, perturbations in nutrition that adversely impact the ce...
TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model [0.03%]
肿瘤坏死因子α受体1而非受体2影响大鼠椎间盘纤维环和髓核对细胞因子刺激的反应
Timothy D Jacobsen,S Olga Yiantsos,Jennifer Gansau et al.
Timothy D Jacobsen et al.
Background: Painful intervertebral disc (IVD) degeneration (IVDD) involves chronic inflammation. Developing translational immunomodulatory strategies for IVDD is a priority with tumor necrosis factor alpha (TNFα) signali...
In Vitro Validation of Pulsed Electromagnetic Field (PEMF) as an Effective Countermeasure Against Inflammatory-Mediated Intervertebral Disc Degeneration [0.03%]
脉冲电磁场(PEMF)作为治疗炎性介导的椎间盘退变的有效措施的体外验证
Laura Guarnaccia,Laura Begani,Silvana Pileggi et al.
Laura Guarnaccia et al.
Background: Intervertebral disc (IVD) degeneration (IDD) is the main contributor to chronic low back pain (LBP), the leading cause of disability worldwide, with a significant impact on the quality of life and health of co...