Introduction to a Special Issue Describing an Observational Cohort of Adults With Chronic Low Back Pain [0.03%]
一篇关于慢性下腰痛成人观察队列的专题介绍
Nam V Vo,Gwendolyn A Sowa
Nam V Vo
Editorial
JOR spine. 2025 Dec 25;8(4):e70150. DOI:10.1002/jsp2.70150 2025
Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche [0.03%]
理解健康和退变椎间盘生态位模拟中髓核细胞的生理行为
Joseph Snuggs,Shaghayegh Basatvat,Exarchos Kanelis et al.
Joseph Snuggs et al.
Introduction: The natural environment within the nucleus pulposus (NP) is hypoxic, acidic, low in nutrition, and exerts a high osmotic pressure. NP cells have adapted to this harsh environment; however, in vitro condition...
Enhanced Quantitative Assessment of Lumbar Facet Joint Degeneration: Refining the Joint Degeneration Grading System With Grayscale Curve Fitting and Imaging Parameter [0.03%]
改良腰椎小关节退变定量评估：基于灰度曲线拟合及影像参数的小关节分级系统修订
Xiaowen Liu,Mingjian Sun,Shouyu He et al.
Xiaowen Liu et al.
Background: Low back pain (LBP) is a leading cause of disability, often progressing to chronic low back pain (CLBP), which often involves facet joint degeneration. The Weishaupt grading system is widely used to evaluate f...
Macrophage Subtypes Distinctly Impact Intervertebral Disc Inflammation and Extracellular Matrix Composition [0.03%]
巨噬细胞亚型对椎间盘炎症和细胞外基质组成的影响不同
Lauren E Lisiewski,Leonardo Campos,Timothy D Jacobsen et al.
Lauren E Lisiewski et al.
Background: Intervertebral disc (IVD) degeneration is characterized by changes in extracellular matrix (ECM) composition and an inflammatory microenvironment, including macrophage recruitment. While inflammation is known ...
Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines [0.03%]
比较分析择那单抗和贝唑来昔芬对骨质疏松症脊柱椎弓根螺钉稳定性的有限元分析
Tomoyuki Asada,Soji Tani,Tomoko Towatari et al.
Tomoyuki Asada et al.
Introduction: Pedicle screw fixation in osteoporotic spines remains challenging. Bazedoxifene (BZA) and denosumab (Dmab) are widely used agents for osteoporosis, but their comparative effects on spinal instrumentation are...
Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis [0.03%]
椎间盘蛋白聚糖：多才多艺的组织稳定和细胞调控蛋白质，控制着组织稳态
James Melrose
James Melrose
The intervertebral disc (IVD) is a tough fibrocartilaginous viscoelastic cushion interposed between spinal vertebrae. It has a composite structure whose material properties are due to the interplay between fibrillar collagens which, provide...
Development and Characterization of a Tunable PDMS Substrate Model for Investigating Elastic Properties and Mechanical Stretching in Intervertebral Disc Cells [0.03%]
一种用于探究椎间盘细胞弹性性能和机械拉伸的可调式PDMS基底模型的研究及特性分析
Johannes Hasler,Mikkael Lamoca,Kory Schimmelpfennig et al.
Johannes Hasler et al.
Background: Aberrant mechanical loading and altered extracellular matrix (ECM) composition favor catabolic cell responses, contributing to intervertebral disc (IVD) degeneration and ultimately impairing the integrity of t...
The Prognostic Significance of LINC00638 in Lumbar Disc Herniation and Its Effect on Senescence of Nucleus Pulposus Cells [0.03%]
LINC00638在腰椎间盘突出症中的预后价值及其对髓核细胞衰老的影响
Zhen Wang,Jichen Liu,Yanhua Sun et al.
Zhen Wang et al.
Background: Lumbar disc herniation (LDH) is a common degenerative spinal disorder that severely impacts patients' quality of life. This study investigated the prognostic values of the lncRNA LINC00638 in LDH and its regul...
Thoracolumbar Biomechanical Analysis of Lenke Type 1 Adolescent Idiopathic Scoliosis Across Roussouly Classifications [0.03%]
Roussouly分型对Lenke1型特发性青少年脊柱侧凸胸腰段生物力学特性的影响研究
Zhihua Wu,Huantong Cheng,Jia He et al.
Zhihua Wu et al.
Background: Lenke type 1 is the most common adolescent idiopathic scoliosis (AIS), and its sagittal morphology critically influences progression and treatment. However, its biomechanical characteristics across Roussouly t...
Subject-Specific Musculoskeletal Modeling: The Future of Predicting and Preventing Proximal Junctional Failure in Adult Spinal Deformity [0.03%]
针对成人脊柱畸形预测和预防近端脊柱关节失败的学科特异性肌肉骨骼建模：未来之路
Nima Ashjaee,Alexa Semonche,Anthony L Mikula et al.
Nima Ashjaee et al.
Background: Adult spinal deformity (ASD) is an increasingly prevalent disorder in the aging population. Surgical intervention is a common and generally effective treatment for severe cases. However, it is associated with ...