Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective [0.03%]
穿刺损伤性椎间盘退变动物模型的二十年回顾
Charu Jain,Jonathan J Huang,Yunsoo Lee et al.
Charu Jain et al.
Background: Intervertebral disc (IVD) degeneration (IVDD) is a major cause of global disability. Three papers on puncture models of IVDD were published 20 years ago, transforming the application of preclinical animal mode...
Evaluation of a Force-Control Experimental Method to Perform Unconstrained Load-Induced Subsidence Testing of Spinal Interbody Implants [0.03%]
评估执行脊柱椎间植入物非约束载荷诱导沉降试验的力控制实验方法的效果
Rémy Benais,Richard Barina,Stewart McLachlin
Rémy Benais
Introduction: Intervertebral body fusion devices ("interbody cages") used in spinal surgeries are susceptible to axial and/or rotational subsidence into the underlying vertebral bone. Experimental testing standards to exa...
Effect of Vertebral Body Tether Tensioning on Vertebral Body Growth Modulation [0.03%]
椎体牵拉张力对脊柱生长调控的影响研究
Taylor J Jackson,Craig Louer,Ron El-Hawary et al.
Taylor J Jackson et al.
Background: The relationship between tether tension and spinal growth modulation following vertebral body tethering (VBT) has not been studied in growing children. ...
Short-Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One-Strike Trigger [0.03%]
短期动态卸载部分缓解牛尾盘在体外一次性诱发的退变
Astrid Soubrier,Hermann Kasper,Nadja Vonlanthen et al.
Astrid Soubrier et al.
Introduction: Intervertebral disc (IVD) degeneration is driven by a vicious circle of interrelated biological and biomechanical factors. Dynamic unloading, defined as dynamic partial decompression, promotes water and meta...
Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain [0.03%]
软骨发育不良犬盘源性背痛的临床大型动物模型研究
Mary K Heimann,Shirley N Tang,Gilian Gunsch et al.
Mary K Heimann et al.
Background: Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP) in humans and canines. IVD degeneration affects the structure and function of both the disc and the innervating dorsal root gangli...
Demographic and Biomedical Characteristics of an Observational Cohort With Chronic Low Back Pain: A Descriptive Analysis [0.03%]
慢性下腰痛观察队列的流行病学和生物医学特征描述性分析
Sara R Piva,Clair Smith,William Anderst et al.
Sara R Piva et al.
Background: The chronic low back pain (cLBP) literature rarely includes comprehensive characterization of demographic and biomedical factors in a large sample of individuals. The University of Pittsburgh Mechanistic Resea...
Impact of Habitual Flexion on Bone Formation After Spinal Fusion Surgery: An In Silico Study [0.03%]
术后习惯性屈曲对脊柱融合手术后骨形成的影响：基于计算机模拟的研究
Siddarth Ananth Swaminathan,Nima Taheri,Luis Becker et al.
Siddarth Ananth Swaminathan et al.
Background: Lumbar spinal fusion is currently regarded as one of the most effective surgical treatments for patients with spinal deformities, degenerative disc disease, and degenerative spondylolisthesis. However, the pro...
Ultrafine-Grained Materials With Antibacterial Properties: A Novel Approach to Reducing Spinal Implant-Associated Infections [0.03%]
具备抗菌性能的超细晶材料：减少脊柱植入物相关感染的新方法
Mitsuhiro Nishizawa,Diane Hu,Hassan Serhan et al.
Mitsuhiro Nishizawa et al.
Background: Implant-associated infection remains a serious complication of instrumented spinal surgery. Since biofilm formation on the implant surface is a key factor in the pathogenesis of such infections, current preven...
Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi-Axial Perspective of Mechanical, Immune, and Metabolic Pathways [0.03%]
椎间盘退变终板细胞衰老的机制交互：力学、免疫及代谢通路的多轴视角
Yunbo Yang,Haoming Li,Junhui Zuo et al.
Yunbo Yang et al.
Background: The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain. Abnormal mechanical stress causes intracellular Ca2+ ove...
The Helical Compliance Vector: Utility for Quantifying Spinal Mechanics [0.03%]
螺旋顺应性向量在脊柱力学量化中的应用研究
Matthew R MacEwen,Rebecca E Abbott,Victor H Barocas et al.
Matthew R MacEwen et al.
Background: This study introduces the helical compliance vector (HCV), a novel measuring parameter that quantifies the orientation and magnitude of joint compliance (inverse of stiffness) by integrating kinetic and kinema...