Tgfbr2 is required in Acan-expressing cells for maintenance of the intervertebral and sternocostal joints [0.03%]
Tgfbr2在Acan表达细胞中对维持椎间关节和肋软骨生长板是必需的
Bashar Alkhatib,Cunren Liu,Rosa Serra
Bashar Alkhatib
Background: Members of the transforming growth factor beta (TGF-β) family are secreted proteins that regulate skeletal development. TGF-β signaling is critical in embryonic development of the annulus fibrosus (AF) of th...
Bailey V Fearing,Paula A Hernandez,Lori A Setton et al.
Bailey V Fearing et al.
Mechanical loading of the intervertebral disc (IVD) initiates cell-mediated remodeling events that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus fibrosus (AF), will exhibit various responses to differen...
The chondrodystrophic dog: A clinically relevant intermediate-sized animal model for the study of intervertebral disc-associated spinal pain [0.03%]
椎软骨营养不良犬：椎间盘相关性腰腿痛研究的中型动物模型
Kelly Thompson,Sarah Moore,Shirley Tang et al.
Kelly Thompson et al.
Low back pain (LBP) is the leading cause of disability worldwide, with an estimated 80% of the American population suffering from a painful back condition at some point during their lives. The most common cause of LBP is intervertebral disc...
Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model [0.03%]
TNF-α抑制剂在诱导椎间盘损伤时使用可减轻大鼠模型长期疼痛和退变
Thomas W Evashwick-Rogler,Alon Lai,Hironobu Watanabe et al.
Thomas W Evashwick-Rogler et al.
Background: Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor-alpha (TNFα) is commonly associated with low back pain, but the dire...
Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine [0.03%]
2007至2016年脊柱研究的出版趋势：美国骨科研究协会脊柱分会与国际腰椎研究学会比较
John T Martin,Sarah E Gullbrand,Aaron J Fields et al.
John T Martin et al.
This study investigated current trends in spine publications of the membership of Orthopaedic Research Society Spine Section (ORS3) and the more global and clinically focused International Society for the Study of the Lumbar Spine (ISSLS). ...
Posterior Ligamentum Complex Preservation Alleviate ASD-Related Biomechanical Deterioration in Lumbar Interbody Fusion Models: A Finite Element Analysis [0.03%]
后韧带复合体保护可缓解腰椎椎间融合术模型中退变性腰椎滑脱的相关生物力学恶化：一种有限元分析方法
Background: There are differences in the extent of excision of articular processes, spinal processes and posterior ligamentum complexes (PLC) for posterior approach lumbar interbody fusion. Given that the biomechanical si...