Combined Flexion, Torsion and Compression Drive Distinct Intervertebral Disc Failure Mechanisms Under Asymmetric, High-Cycle Loading [0.03%]
结合屈曲、扭转和压缩的不对称高周次加载下腰椎间盘损伤机制研究
Amra Šećerović,Aapo Ristaniemi,Francesco Crivelli et al.
Amra Šećerović et al.
Background: Recent advancements in next-generation bioreactors have substantially improved the simulation of complex, detrimental spinal mechanics in ex vivo intervertebral disc models. This study investigated interverteb...
Biomechanical Analysis and Injury Prediction in Pilots With Lumbar Spondylolysis Under Different Seat Inclination Angles [0.03%]
不同座椅倾角条件下腰椎峡部裂飞行员生物力学分析及伤情预测研究
Mengmeng Jin,Yingwei Li,Jiatao Wang et al.
Mengmeng Jin et al.
Background: This study aims to quantify the biomechanical effects of different seat inclinations on the normal and spondylolysis lumbar of pilots under typical fighter aircraft maneuver loads, providing data support for o...
Advancement in the Methods for Isolating High Quality RNA From Mouse and Rat Intervertebral Disc [0.03%]
改进小鼠和大鼠椎间盘高质量RNA分离方法的研究进展
Min Kyu M Kim,Lauren E Lisiewski,Hagar M Kenawy et al.
Min Kyu M Kim et al.
Background: Extracting high-quality RNA from intervertebral disc (IVD) tissues poses a great technical challenge due to the presence of a proteoglycan-rich extracellular matrix and naturally occurring RNases. Current stud...
In-Field Ecological Momentary Assessment From Wearable Motion Sensors and Self-Report in a Chronic Low Back Pain Cohort [0.03%]
慢性下腰痛队列中可穿戴运动传感器和自我报告的现场生态瞬时评估
Kevin M Bell,Zakiy Alfikri,William Anderst et al.
Kevin M Bell et al.
Background: Chronic low back pain (cLBP) is a prevalent and debilitating condition. Gaining insight into the daily experiences of those with cLBP is crucial for developing effective management. Pain and activity are typic...
Complex Mechanical Loading and Pro-Inflammatory Cytokines in Intervertebral Disc Degeneration [0.03%]
力学因素和促炎细胞因子在椎间盘退变中的作用
Katherine B Crump,Estefano Muñoz-Moya,Kim de Graaf et al.
Katherine B Crump et al.
Background: Intervertebral disc (IVD) degeneration is a major contributor to low back pain, yet its initiating factors remain unclear. While the individual effects of pro-inflammatory cytokines and mechanical loading on I...
Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells [0.03%]
微环境对山羊椎间盘髓核细胞基质合成和代谢的影响
Niamh Wilson,Tara Ní Néill,Jake McDonnell et al.
Niamh Wilson et al.
Background: The intervertebral disc (IVD) microenvironment plays a crucial role in cellular function and viability. Although the precise cause of IVD degeneration remains unclear, it is associated with progressive disrupt...
Sex Hormones Attenuate Pro-Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell-Type Specific Manner [0.03%]
性激素以细胞类型特异性方式降低髓核和纤维环细胞中促炎基因表达
Jeffrey L Hutchinson,Andrew E Leung,Cheryle A Séguin
Jeffrey L Hutchinson
Background: Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease-modifying treatments. Sex steroids, primarily testost...
Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals [0.03%]
与健康人相比，癌症患者的转移性脊柱疾病改变了椎体的载荷-强度比
Dennis E Anderson,Mario Keko,Joanna James et al.
Dennis E Anderson et al.
Purpose: This study investigated the effect of bone metastasis on the biomechanical environment of human vertebrae in patients with metastatic spine disease through the metric of load-to-strength ratio (LSR). Specifically...
A Multiscale Ex Vivo Method to Investigate Intervertebral Disc Strain and Fiber Recruitment in Anterolateral Bending Using 9.4T MRI-DVC and DIC Microscopy [0.03%]
一种多尺度体外方法，用于使用9.4T MRI-DVC和DIC显微镜研究前外侧弯曲下的椎间盘应变和纤维募集
T D Slater,K A Raftery,V M van Heeswijk et al.
T D Slater et al.
Study design: Ex vivo, multiscale analysis of disc strain using ultrahigh-field MRI-based digital volume correlation (MRI-DVC) and differential interference contrast (DIC) microscopy. ...
Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV-idence? [0.03%]
外泌体在椎间盘再生中的潜力：证据何在？
Daniele Corraini,Chantal Voskamp,Marca H M Wauben et al.
Daniele Corraini et al.
Background: Extracellular vesicles (EVs) represent a promising cell-free regenerative therapy. Deciphering their mode and mechanism of action comes with technical and biological challenges. This scoping review presents a ...