Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section [0.03%]
椎间盘再生的细胞疗法从实验室到临床研究的建议——美国骨矿研究会脊柱分会的意见书
Lachlan J Smith,Lara Silverman,Daisuke Sakai et al.
Lachlan J Smith et al.
Intervertebral disc degeneration is strongly associated with chronic low back pain, a leading cause of disability worldwide. Current back pain treatment approaches (both surgical and conservative) are limited to addressing symptoms, not nec...
Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering [0.03%]
椎间盘修复和再生的关键方面及挑战-利用组织工程学的最新进展
Conor T Buckley,Judith A Hoyland,Kengo Fujii et al.
Conor T Buckley et al.
Low back pain represents the highest burden of musculoskeletal diseases worldwide and intervertebral disc degeneration is frequently associated with this painful condition. Even though it remains challenging to clearly recognize generators ...
Cheryle A Séguin,Danny Chan,Chitra L Dahia et al.
Cheryle A Séguin et al.
This paper is a concise review aiming to assemble the most relevant topics presented by the authors at ORS-Philadelphia Spine Research Society Fourth International Spine Research Symposium. It centers on the latest advances in disc developm...
New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research [0.03%]
脊柱研究新进展：椎间盘生物学、组织工程学、生物力学、转化和临床研究
Chitra L Dahia,James C Iatridis,Makarand V Risbud
Chitra L Dahia
Tgfbr2 is required in Acan-expressing cells for maintenance of the intervertebral and sternocostal joints [0.03%]
Tgfbr2在Acan表达细胞中对维持椎间关节和肋软骨生长板是必需的
Bashar Alkhatib,Cunren Liu,Rosa Serra
Bashar Alkhatib
Background: Members of the transforming growth factor beta (TGF-β) family are secreted proteins that regulate skeletal development. TGF-β signaling is critical in embryonic development of the annulus fibrosus (AF) of th...
Bailey V Fearing,Paula A Hernandez,Lori A Setton et al.
Bailey V Fearing et al.
Mechanical loading of the intervertebral disc (IVD) initiates cell-mediated remodeling events that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus fibrosus (AF), will exhibit various responses to differen...
The chondrodystrophic dog: A clinically relevant intermediate-sized animal model for the study of intervertebral disc-associated spinal pain [0.03%]
椎软骨营养不良犬：椎间盘相关性腰腿痛研究的中型动物模型
Kelly Thompson,Sarah Moore,Shirley Tang et al.
Kelly Thompson et al.
Low back pain (LBP) is the leading cause of disability worldwide, with an estimated 80% of the American population suffering from a painful back condition at some point during their lives. The most common cause of LBP is intervertebral disc...
Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model [0.03%]
TNF-α抑制剂在诱导椎间盘损伤时使用可减轻大鼠模型长期疼痛和退变
Thomas W Evashwick-Rogler,Alon Lai,Hironobu Watanabe et al.
Thomas W Evashwick-Rogler et al.
Background: Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor-alpha (TNFα) is commonly associated with low back pain, but the dire...
Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine [0.03%]
2007至2016年脊柱研究的出版趋势：美国骨科研究协会脊柱分会与国际腰椎研究学会比较
John T Martin,Sarah E Gullbrand,Aaron J Fields et al.
John T Martin et al.
This study investigated current trends in spine publications of the membership of Orthopaedic Research Society Spine Section (ORS3) and the more global and clinically focused International Society for the Study of the Lumbar Spine (ISSLS). ...
Posterior Ligamentum Complex Preservation Alleviate ASD-Related Biomechanical Deterioration in Lumbar Interbody Fusion Models: A Finite Element Analysis [0.03%]
后韧带复合体保护可缓解腰椎椎间融合术模型中退变性腰椎滑脱的相关生物力学恶化：一种有限元分析方法
Background: There are differences in the extent of excision of articular processes, spinal processes and posterior ligamentum complexes (PLC) for posterior approach lumbar interbody fusion. Given that the biomechanical si...