Plasma Pro- and Anti-Inflammatory Cytokines in an Observational Chronic Low Back Pain Cohort [0.03%]
慢性下腰痛队列的等离子促炎和抗炎细胞因子观察研究
Valerio Tonelli Enrico,William Anderst,Kevin M Bell et al.
Valerio Tonelli Enrico et al.
Background: Chronic low back pain (cLBP) is a multifactorial condition that can have various contributing factors, including biological, biomechanical, and behavioral. Recent evidence suggests that systemic inflammation m...
MRI-Based Grading Systems for Assessing Lumbar Disc Degeneration: A Scoping Review [0.03%]
基于磁共振成像的评估腰椎间盘退变系统：系统综述
Dean Esposito,Benjamin Brown,Mark Jonathan Hancock et al.
Dean Esposito et al.
Background context: An array of different MRI (magnetic resonance imaging) based grading systems is used to measure disc degeneration (DD) in the lumbar spine. It is currently unclear which grading systems are most common...
Comprehensive Evaluation of Facet Joints Osteoarthritis Radiological Features on Lumbar CT: A Multitask Deep Learning Approach [0.03%]
基于多任务深度学习的腰椎CT图像 facet 关节骨关节炎综合评价方法研究
Yunfei Wang,Ziyang Chen,Junzhang Huang et al.
Yunfei Wang et al.
Background: Accurately evaluating the radiological features of facet joint osteoarthritis (FJOA) may help to elucidate its relationship with pain. Multitask deep learning (DL) models have emerged as promising tools for th...
Validation of a Coordinate Optimization Approach for Assessment of In Vivo Intervertebral Kinematics in Patients With Adult Spinal Deformity and Healthy Older Adults [0.03%]
成人脊柱畸形和健康老年人体内椎间关节运动学评估的坐标优化方法验证
Birgitt Peeters,Mario Keko,Lennart Scheys et al.
Birgitt Peeters et al.
Background: Spine kinematics assessment is crucial for understanding intervertebral joint motion, particularly in conditions like spinal deformity, which alters and reduces spinal motion. Estimating spine kinematics in vi...
Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats [0.03%]
advanced glycation end products诱导卵巢切除雌性大鼠尾椎退变
Xiao Liang,Zhaohui Li,Pengcheng Ren et al.
Xiao Liang et al.
Background: Preclinical animal models are indispensable for the development of new therapeutic strategies and the study of the pathological mechanisms of intervertebral disc (IVD) degeneration (IVDD). This study aims to d...
A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration [0.03%]
横断面组织转录组-wide关联研究鉴定出椎间盘退变的易感基因
Li Zhang,Wen Zhao,Hongsheng Yang et al.
Li Zhang et al.
Background: Intervertebral disc degeneration (IDD) is a prevalent spinal condition frequently associated with pain and motor impairment, imposing a substantial burden on quality of life. Despite extensive investigations i...
TRIM25-Mediated Ubiquitination and Degradation of SOX8 Promotes Ligament Fibroblast Osteogenic Differentiation and Regulates OPLL Progression by Inhibiting OSR2 Transcription [0.03%]
TRIM25介导的SOX8泛素化降解促进韧带纤维细胞成骨分化并通过抑制OSR2转录调控 ossification of the posterior longitudinal ligament进展
Zhenqiang Wang,Yifan Tang,Changjiang Gu et al.
Zhenqiang Wang et al.
Background: Ossification of the posterior longitudinal ligament (OPLL) is a pathological condition characterized by ectopic ossification of spinal ligaments, primarily driven by abnormal osteogenic differentiation of liga...
Wharton's Jelly Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System [0.03%]
惠特克凝胶间充质基质细胞源性外泌体通过三维共培养系统减轻炎症应激下椎间盘退变
Veronica Tilotta,Gianluca Vadalà,Giuseppina Di Giacomo et al.
Veronica Tilotta et al.
This study explores the therapeutic potential of extracellular vesicles (EVs) derived from Wharton's Jelly mesenchymal stem cells in an in vitro 3D model of intervertebral disc degeneration under inflammatory stress. The treatment with WJ-M...
Quantitative Sensory Testing in an Observational Cohort of Adults With Chronic Low Back Pain [0.03%]
成人慢性下腰痛队列的感觉定量检测评估
Michael J Schneider,Carol M Greco,Amanda M Acevedo et al.
Michael J Schneider et al.
Background: Quantitative Sensory Testing (QST), also known as psychophysical testing, includes standardized methods for assessing humans' perceptions of different types of sensory stimuli and their associated pain thresho...
Biological Sex Is Under-Reported in Cartilage-Related Preclinical Research: A Cross-Sectional Analysis [0.03%]
软骨相关基础研究中生物学性别的报告不足：横断面分析
Daniele Zuncheddu,Paola Buedo,Martin J Stoddart et al.
Daniele Zuncheddu et al.
Background: Intervertebral disc degeneration (IDD) and osteoarthritis (OA) share many similarities in the molecular processes involved in the onset and progression of these musculoskeletal pathologies. Biological sex is a...