Comparative Analysis of Dual-miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair [0.03%]
双miRNA介导的椎间盘细胞和骨髓干细胞刺激的比较分析用于椎间盘修复研究
Tara Ní Néill,Niamh Wilson,Jake McDonnell et al.
Tara Ní Néill et al.
Background: Intervertebral disc (IVD) degeneration is the primary cause of low back pain (LBP). Disease progression is characterized by a shift in extracellular matrix homeostasis towards degradation over regeneration, a ...
Viscoelastic and Morphologic Changes in the Lumbar Intervertebral Discs of the 5xFAD Mouse Model of Alzheimer's Disease [0.03%]
5XFAD小鼠模型中腰椎间盘的黏弹性和形态学变化
C E Gonzalez,C A Schurman,K A Wilson et al.
C E Gonzalez et al.
Background: Chronic low back pain, commonly associated with intervertebral disc (IVD) degeneration, is highly prevalent in patients with Alzheimer's disease (AD), and the severity of the pain is correlated with the severi...
Lifetime Physical Loading and Magnetic Resonance-Derived Intervertebral Disc Health in Adults With Chronic Low Back Pain: A Cross-Sectional Study [0.03%]
成人慢性下腰痛患者一生中的物理负荷与磁共振成像显示的椎间盘健康状况：横断面研究
Claire L Samanna,Christopher Neason,Scott D Tagliaferri et al.
Claire L Samanna et al.
Background: The intervertebral disc (IVD) is a mechanosensitive structure influenced by physical loading (physical activity/sport/exercise); however, the optimal type and parameters of physical loading for IVD health rema...
Deletion of a Pax1 Sex-Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice [0.03%]
小鼠Pax1性别相关基因组区域的删除与青少年特发性脊柱侧弯有关联导致椎间盘退变、不稳和椎体旋转
Edward C Moody,Emma M Wade,Shuji Mizumoto et al.
Edward C Moody et al.
Background: Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity characterized by three-dimensional curvature of the spine with an unknown etiology. Previous genome-wide association studies have identified ...
Detrimental Effect of Low-Magnitude High-Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment [0.03%]
低幅度高频振动通过体外模型促进间盘退变独立于雌激素治疗效应
Jan Ulrich Jansen,Felizitas Figel,Franziska Widmayer et al.
Jan Ulrich Jansen et al.
Introduction: Postmenopausal females are at increased risk of intervertebral disc (IVD) degeneration due to estrogen decline. While both estrogen supplementation and low-magnitude high-frequency vibration (LMHFV) are prop...
Intradiscal Cutibacterium acnes Sustains Modic Type 1-Like Lesions Over Time in a Rat Lumbar Endplate Injury Model [0.03%]
盘内芽孢杆菌诱导的椎间盘感染可长期维持腰椎终板损伤模型中的莫迪克1型病变
Irina Heggli,Alon Lai,Denise Iliff et al.
Irina Heggli et al.
Background: Modic changes (MC) are painful vertebral bone marrow lesions. Three interconvertible types represent different pathology stages with MC1 being the most painful, MC2 less painful, and MC3 asymptomatic. Bacteria...
Modic Change Bone Marrow Neutrophils Are Activated and Degrade Cartilage Endplates [0.03%]
莫迪克变性椎体终板骨髓中活化的中性粒细胞及其降解软骨终板的作用
Irina Heggli,Tamara Mengis,Jan Devan et al.
Irina Heggli et al.
Background: Vertebral endplate bone marrow lesions (Modic changes, MC) are linked to vertebrogenic pain and to structural defects of the bony and cartilaginous endplates (CEP). However, the immune mechanisms that may perp...
Characterization of Ovine Intervertebral Disc Health Across the Lifespan: Relationships Between Quantitative MRI, Radiological, Histological, Biochemical, and Biomechanical Assessments [0.03%]
绵羊椎间盘健康的终身表征：磁共振成像、影像学、组织学、生化和生物力学评估之间的关系
Yaqoub Yusuf,Rebecca E Abbott,Erick O Buko et al.
Yaqoub Yusuf et al.
Background: Intervertebral disc (IVD) degeneration contributes significantly to chronic low back pain and represents a major clinical challenge. Quantitative MRI (qMRI) techniques offer the potential to assess biochemical...
Feasibility of Smartphone-Derived Short-Interval Walking Tests for Monitoring Functional Recovery After Spine Surgery [0.03%]
基于智能手机的短间隔步行测试监测脊柱手术后功能恢复的可行性研究
J Puhakka,M Jung,T Fekete et al.
J Puhakka et al.
Background: Traditional assessments of functional recovery after spine surgery rely on patient-reported outcomes, which are prone to bias. Wearables and smartphone activity tracking offer objective monitoring but may be u...
Platelet-Rich Fibrin Induces New Bone Formation to Promote Extreme Lateral Interbody Fusion of Spine in Rabbits [0.03%]
富血小板纤维蛋白诱导新生骨形成促进兔脊柱极外侧融合手术后的骨融合
Weijian Wang,Jiaqi Li,Han Wu et al.
Weijian Wang et al.
Background: Achieving rapid bone fusion is critical for preventing complications in Extreme Lateral Interbody Fusion (XLIF), yet harvesting sufficient autologous bone presents surgical limitations. Platelet-rich fibrin (P...