Reduced Shear Modulus and Altered Lamellar Morphology of the Outer Annulus Fibrosus in Painful Intervertebral Disc Degeneration Compared With Tissue From Non-Surgical Controls [0.03%]
与非手术对照组相比，疼痛性椎间盘退变的外纤维环剪切弹性模量降低和片状形态改变
Taylor J Bader,Manmeet Dhiman,Lucas Lo Vercio et al.
Taylor J Bader et al.
Background: Stability of the spine and intervertebral disc (IVD) integrity is enabled by the highly organized fibrocartilaginous annulus fibrosus (AF). The shear properties of the AF are important in maintaining IVD integ...
High-Resolution 3-Dimensional Micro-CT Imaging of Intervertebral Discs Using a Novel Contrast Agent [0.03%]
一种新型对比剂应用于椎间盘高分辨率三维显微CT成像技术中
Madison M Buckles,Abdulkadir Nur,Nada H Warda et al.
Madison M Buckles et al.
Background: The nucleus pulposus (NP) in the intervertebral disc (IVD) is the first structure to exhibit degenerative changes during IVD degeneration (IDD). Currently, micro-computed tomography (micro-CT) imaging of the N...
Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis [0.03%]
人和小鼠腰椎间盘退变的年龄及节段定位特点：比较分析
Ravij Mehta,Sarthak Mohanty,Andrew Parker Hallmark et al.
Ravij Mehta et al.
Background: Aging is a major risk factor for IVD degeneration and chronic lower back pain. Comparing degenerative patterns in human and mice, a commonly used pre-clinical model, is crucial for validating it in preclinical...
Automated Computational Pathology to Assess Degenerative Disc Histology [0.03%]
用于评估退行性椎间盘组织病理的计算病理学自动化技术
Richard D Bell,Evie C Reddick,David J Lillyman et al.
Richard D Bell et al.
Background: Preclinical models of disc degeneration are important tools to discover disease pathology. Histopathology is often used to understand these changes, but analyses remain reliant on pathologists or graders using...
Mobile Health (mHealth) for Chronic Low Back Pain Assessment: Design, Development, and Usability Evaluation [0.03%]
移动健康（mHealth）在慢性下腰痛评估中的设计、开发和可用性评价
Zakiy F Alfikri,Marit E Johnson,Brad E Dicianno et al.
Zakiy F Alfikri et al.
Background: Chronic low back pain (cLBP) requires precise phenotyping for tailored treatments. This study introduces a mobile health (mHealth) system for cLBP assessment, aiming to collect extensive biomechanical and beha...
Single-Side Iatrogenic Pedicle Injury May Trigger an Increased Risk of Contralateral Screw Loosening: An In Silico Study [0.03%]
单侧医源性椎弓根损伤可能增加对侧螺钉松动的风险：一项计算机模拟研究
Jiexiang Yang,Junjie Chen,Guoyou Wang et al.
Jiexiang Yang et al.
Background: Screw loosening is a frequently reported complication following pedicle screw fixation, resulting in various adverse outcomes. The primary trigger for screw loosening is biomechanical deterioration. Iatrogenic...
Vertebral Growth Modulation Through Periosteal Resection and Fixed Length Deformity Overcorrection: Computational and In Vivo Pilot Study [0.03%]
periosteal切除和固定长度畸形过度矫正对椎体生长调控的计算及在体初步研究
Matthew A Halanski,Cameron Jeffers,Yousuf Abubakr et al.
Matthew A Halanski et al.
Background: Vertebral body tethering (VBT) is a fusionless surgical technique for correcting spinal deformities through asymmetric growth inhibition. Standard VBT often relies on intraoperative overcorrection with an ante...
Lumbopelvic Kinematics During Functional Tasks in a Chronic Low Back Pain Observational Cohort [0.03%]
慢性下腰痛观察队列的功能任务中的腰骨盆运动学分析
Kevin M Bell,Rachel E Roos,Zakiy Alfikri et al.
Kevin M Bell et al.
Background: The University of Pittsburgh Mechanistic Research Center, entitled, "Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes (LB3P)," is part of the National Institutes of Health's Helping to End Addic...
A Comparison of Five Animal Models for Acute Intervertebral Disc Herniation Research [0.03%]
五种急性椎间盘突出动物模型的比较研究
Thomas D Slater,Beatrice Gagliostri,Matthew J Kibble et al.
Thomas D Slater et al.
Study design: Microstructural investigation of mechanical load induced acute disc herniation on five animal models. Objective: To compa...
Exploring the Biopsychosocial Impact of Chronic Low Back Pain in Workers Through Artificial Intelligence-Driven Phenotyping [0.03%]
利用人工智能驱动的表型分析探索慢性下腰痛对工人生物心理社会影响
Paolo Giaccone,Elisabetta de Rinaldis,Federico D&#x;Antoni et al.
Paolo Giaccone et al.
Study design: Cross-sectional retrospective cohort study. Objectives: Chronic low back pain (cLBP) is a major cause of disability world...