Lovastatin-Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle-Puncture Induced Degeneration Model in Rat Caudal Discs [0.03%]
载洛伐他汀纳米粒的热敏性壳聚糖水凝胶缓释系统治疗椎间盘退变：体外细胞培养研究及大鼠尾部椎间盘穿刺诱导退变模型体内评价
Chih-Wei Chen,Yung-Hsin Cheng,Kai-Chiang Yang et al.
Chih-Wei Chen et al.
Background: Sustained release of therapeutic factors, such as lovastatin, is theoretically more beneficial than a single injection in promoting anabolic stimulation to nucleus pulposus cells/tissues. This study aimed to d...
PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis [0.03%]
PIEZO1-主纤毛轴介导了特发性青少年脊柱侧凸生长板退变和骨化中的压缩应力反应
Fei Chen,Shuqing Chen,Fushuai Peng et al.
Fei Chen et al.
Background: Adolescent idiopathic scoliosis (AIS) is linked to mechanical stress-induced growth plate dysfunction. PIEZO1 (mechanosensitive ion channel) mediates chondrocyte apoptosis via calcium, and primary cilia (mecha...
Beyond the Curve: The Muscle-Specific Asymmetries of Adolescent Idiopathic Scoliosis [0.03%]
青少年特发性脊柱侧弯的肌肉不对称超越了曲线模式
Phoebe Duncombe,Taylor Dick,Phoebe T T Ng et al.
Phoebe Duncombe et al.
Background: Adolescent idiopathic scoliosis (AIS) describes an asymmetrical formation of the spine that develops rapidly during adolescence. It is well known that the forces applied to bones, such as from paraspinal muscl...
The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho-Anatomical Studies: A Historical Perspective [0.03%]
羊环形病变模型对椎间盘病理生物学的影响以及羊脊柱模型在病理解剖学研究中的作用：历史回顾
O Osti,C B Little,J Melrose
O Osti
This review documents the impact of the Osti ovine annular lesion model of intervertebral disc (IVD) degeneration on the elucidation of degenerative changes in the ovine IVD also seen in human IVD degeneration (IVDD). The degenerative patho...
Correction to "Patient-Reported Outcomes Among an Observational Cohort of Individuals With Chronic Low Back Pain" [0.03%]
对“慢性下腰痛观察队列患者结局”的纠正
[This corrects the article DOI: 10.1002/jsp2.70097.]. © 2025 Orthopaedic Research Society.
Published Erratum
JOR spine. 2025 Oct 27;8(4):e70132. DOI:10.1002/jsp2.70132 2025
Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics [0.03%]
乳酸代谢在椎间盘退变中的作用：通过生物信息学揭示新机制
Haiyan Sun,Mingwei He,Jinlei Pang et al.
Haiyan Sun et al.
Background: Intervertebral disc degeneration (IDD) is a widespread issue associated with chronic lumbar pain and disability. This study aimed to identify lactate metabolism-related genes in IDD and elucidate their mechani...
Injury Induces More Severe Biomechanical Changes in Middle-Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model [0.03%]
损伤在体外小鼠模型中诱发腰椎生物力学变化的年龄差异性研究
Neharika Bhadouria,Justin Tiao,Angelica Baburova et al.
Neharika Bhadouria et al.
Background: Intervertebral disc degeneration (IVDD) is a major cause of global disability that increases with age. IVD age may affect its injury susceptibility, yet few studies examine spine biomechanical changes with age...
Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment [0.03%]
酶法测定猪椎间盘髓核中Condoliase的行为：活体外和 vitro 评估
Ippei Watanabe,Ko Takeda,Taiichi Shirogane
Ippei Watanabe
Background: Condoliase is a treatment for lumbar disc herniation. This enzyme exerts its medicinal effects by digesting chondroitin sulfate (CS), which is abundant in the nucleus pulposus. However, the behavior of adminis...
Simulating Federated Learning to Enable Multi-Hospital Collaboration for Lumbopelvic Alignment Estimation [0.03%]
模拟联邦学习以实现腰骶部对齐估计的多医院合作
Andrea Cina,Miklovana Tuci,Ferran Pellisé et al.
Andrea Cina et al.
Background: Accurate computation of radiological parameters related to spinal alignment is clinically crucial for diagnosing and managing conditions, such as adolescent idiopathic scoliosis and adult spinal deformities. K...
Advancing Intervertebral Disc Biology via Omics: Implications for Nucleus Pulposus Progenitor Cell-Based Regeneration [0.03%]
组学在椎间盘生物学中的应用及核聚变祖细胞介导再生的展望
Anja Stirnimann,Leon Schlagenhof,Benjamin Gantenbein et al.
Anja Stirnimann et al.
Background: Intervertebral disc (IVD) degeneration (IDD) contributes to global disability and involves incompletely understood molecular processes. Recent advances in omics technologies help to unravel the complex biology...