Impact of Screw Insertion Technique on Thoracic Pedicle Screw Anchorage: Biomechanical Comparison of the Modified Slide, Slide, Funnel, and Conventional Techniques [0.03%]
不同穿刺技术对胸椎椎弓根钉固定稳定性的影响：四种改良置入技术的生物力学比较研究
Richard A Lindtner,Fabian Krumm,Werner Schmoelz et al.
Richard A Lindtner et al.
Background: Several techniques have been developed to facilitate safe and accurate thoracic pedicle screw placement. However, their impact on screw anchorage has not been systematically evaluated. This study compared thor...
Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity [0.03%]
人核髓盘微环境的界定及其对细胞基质合成和代谢活性的影响
Niamh Wilson,Tara Ní Néill,Jake McDonnell et al.
Niamh Wilson et al.
Introduction: Intervertebral disc (IVD) degeneration remains the leading cause of low back pain worldwide. Regenerative therapies focused on restoring extracellular matrix (ECM) composition and disc height often overlook ...
Pre-Conditioned Bone Marrow Mesenchymal Stromal Cell-Derived Secretome Exerts an Anti-Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro [0.03%]
体外预条件骨髓间充质干细胞来源的细胞因子诱导的分泌组对退变椎间盘髓核细胞的抗炎作用
Veronica Tilotta,Gianluca Vadalà,Luca Ambrosio et al.
Veronica Tilotta et al.
Background: Intervertebral disc degeneration (IDD) is frequently associated with chronic low back pain (LBP), which contributes significantly to disability, psychological distress, and reduced work capacity. Mesenchymal s...
Explainable Supervised Learning Classification Model Using Diffusion Tensor Imaging Predicts Postoperative Outcomes in Cervical Spondylotic Myelopathy: A Preliminary Study [0.03%]
基于弥散张量成像的可解释监督学习分类模型预测颈椎病术后结果：一项初步研究
Yifei Peng,Zixuan Zhang,Zhikun Zhang et al.
Yifei Peng et al.
Background: Cervical spondylotic myelopathy (CSM) is common in older adults. Some patients may experience incomplete neurological recovery after surgery, or even deterioration. Accurate prognosis is essential for patients...
Uncertainty Quantification of Central Canal Stenosis Deep Learning Classifier From Lumbar Sagittal T2-Weighted MRI [0.03%]
基于腰椎矢状T2加权MRI的中央管狭窄深度学习分类器的不确定性量化
Adriana Brenzikofer,Maria Monzon,Fabio Galbusera et al.
Adriana Brenzikofer et al.
Background: Accurate assessment of the severity of central canal stenosis (CCS) on lumbar spine MRI is critical for clinical decision-making. We evaluated deep learning models for automated CCS grading on sagittal T2-weig...
Quantitative Disk and Metabolic Bone PET-MRI for Understanding Disk-Endplate Crosstalk in Degeneration of the Lumbar Spine [0.03%]
定量椎间盘和代谢性骨PET-MRI在腰椎退变中的终板相互作用理解中的应用
Virginie Kreutzinger,Katharina Ziegeler,Misung Han et al.
Virginie Kreutzinger et al.
Objectives: The aim of this investigation was to explore the association between disk degeneration, quantified by Pfirrmann grades and T1rho as a marker of hydration, and bone remodeling in the vertebral endplate quantifi...
Application of Statistical Shape Models to Standard Lumbar MRI for Stenosis Treatment Stratification: Severe Versus Normal Stenosis [0.03%]
统计形状模型在标准腰椎MRI中用于脊柱狭窄分层治疗的应用：严重与正常脊柱狭窄的区别
Mary H Foltz,Alexandra Seidenstein,Wesley M Durand et al.
Mary H Foltz et al.
Background: Lumbar spinal stenosis is a prevalent and debilitating diagnosis, which in severe cases requires surgical treatment to relieve nerve root pressure. Often, treatment plans are based in part on subjective, quali...
Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice [0.03%]
腰椎间盘源性下背痛的诊断特征：综述及未来研究和临床实践建议
William Roger Peters,Ashish D Diwan,Mario Giuseppe Zotti
William Roger Peters
Background: Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under...
Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro [0.03%]
应激诱导的椎间盘退变的分泌组及途径分析
Exarchos Kanelis,Andrea Nüesch,Joseph Snuggs et al.
Exarchos Kanelis et al.
Background: Intervertebral disc degeneration (IDD) involves complex inflammatory and oxidative stress pathways within nucleus pulposus (NP) cells, leading to catabolic remodeling and loss of disc function. Traditional sin...
Spinal Implant-Associated Infection in Type 2 and Type 1 Diabetes: Phenotype-Specific Inflammatory Features and Therapeutic Response to Semaglutide [0.03%]
二型和一型糖尿病脊柱植入物相关感染的炎性特征及Semaglutide治疗反应的表型特异性研究
Thomas E Olson,Trevor S Lloyd,Christopher D Hamad et al.
Thomas E Olson et al.
Background: Diabetes mellitus (DM) is a major risk factor for postoperative infection and wound complications in spine surgery, yet distinctions between Type 2 (T2DM) and Type 1 (T1DM) pathophysiology are rarely addressed...