Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions [0.03%]
全部人类脊柱节段的活动范围和中区：在标准化测试条件下进行的为期30年的离体实验的数据收集
Hans-Joachim Wilke,Annette Kienle,Karin Werner et al.
Hans-Joachim Wilke et al.
Background: Spinal flexibility can vary among spinal sections and single motion segments. The purpose of this work was to provide a comprehensive overview of the range of motion (RoM) and neutral zone (NZ) values of all s...
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs [0.03%]
鲁索利替尼在大鼠椎间盘中延缓髓核细胞衰老
Honggang Hao,Weidong Liang,Shuwen Zhang et al.
Honggang Hao et al.
Background: Intervertebral disc degeneration involves aging and senescence of nucleus pulposus cells (NPCs), and JAK/STAT signaling may contribute to this process. The aim of this study was to investigate the therapeutic ...
Mechanism of Intervertebral Disc Degeneration via the β-Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice [0.03%]
Sox9条件性敲除小鼠经β-连环蛋白/CCL2通路介导的椎间盘退变机制研究
Khaled Aboushaala,Ana Chee,Frank Ko et al.
Khaled Aboushaala et al.
Introduction: Degenerative changes in the intervertebral disc (IVD) are known to be a main cause of low back pain (LBP), oftentimes necessitating interventions that may or may not be successful due to a lack of understand...
Gene Expression Changes Precede Elevated Mechanical Sensitivity in the Mouse Intervertebral Disc Injury Model [0.03%]
基因表达的变化先于小鼠椎间盘损伤模型中机械敏感性的升高出现
Zuozhen Tian,Ken Chen,Frances S Shofer et al.
Zuozhen Tian et al.
Background: Back pain after intervertebral disc (IVD) injury is a common clinical problem. Previous work examining early molecular changes post injury mainly used a candidate marker approach. ...
Parallel Networks to Predict TIMP and Protease Cell Activity of Nucleus Pulposus Cells Exposed and Not Exposed to Pro-Inflammatory Cytokines [0.03%]
并行网络预测暴露和未暴露于促炎细胞因子的髓核细胞TIMP和蛋白酶活性
L Baumgartner,S Witta,J Noailly
L Baumgartner
Background: Intervertebral disc (IVD) degeneration is characterized by a disruption of the balance between anabolic and catabolic cellular processes. Within the nucleus pulposus (NP), this involves increased levels of the...
Do we know more about the mechanobiology of the intervertebral disc in space than on Earth? [0.03%]
我们是否比在地球上更了解空间中椎间盘的机学生物学？
Timothy Patrick Holsgrove,Isabelle Ebisch,Daniela Lazaro-Pacheco
Timothy Patrick Holsgrove
This work provides a perspective on the loading protocols used in whole-organ interverterbal disc culture studies using bioreactors. We put this in the context of in vivo spinal loading, and we put forward the case that the majority of prev...
Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc [0.03%]
瞬时受体电位香草酸4通过抑制自噬降低核椎间盘外基质的合成
Tomoya Matsuo,Yoshiki Takeoka,Takashi Yurube et al.
Tomoya Matsuo et al.
Background: Transient receptor potential vanilloid 4 (TRPV4) has been identified as a Ca2+-permeable channel and is activated under physiological mechanical stimulation in disc nucleus pulposus (NP) cells. Meanwhile, the ...
Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology [0.03%]
体外和体内蛋白质组学方法阐明IL-4和IL-10在椎间盘病理生理学中的相关性
Paola Bermudez-Lekerika,Sofia Tseranidou,Exarchos Kanelis et al.
Paola Bermudez-Lekerika et al.
Background: This study investigates the native presence and potential anabolic effects of interleukin (IL)-4 and IL-10 in the human intervertebral disc (IVD). ...
Annulus Fibrosus Repair via Interpenetration of a Non-Woven Scaffold Supports Tissue Integration and Prevents Re-Herniation [0.03%]
互穿非织造支架支持组织整合并预防复发性疝气
Esteban D Ongini,Mohammed Abdullah,Julie B Engiles et al.
Esteban D Ongini et al.
Background: Current surgical management of intervertebral disc herniation often fails to adequately address the risk of recurrence, primarily due to the disc's limited regenerative capacity. Regenerative, biomaterial-base...
The Cross-Sectional Areas and Anterior-Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score-Matched Analysis [0.03%]
颈椎肌萎缩性头部下垂综合征和颈椎脊髓型颈椎病的颈椎多裂肌横截面面积及前后平衡：倾向匹配分析
Takashi Sono,Kenta Ijiri,Kensaku Kakehi et al.
Takashi Sono et al.
Introduction: Dropped head syndrome (DHS) is characterized by weakness of the neck extensor muscles. However, few studies have assessed the cross-sectional areas (CSAs) of the cervical paraspinal muscles (CPM) and their a...