Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats [0.03%]
advanced glycation end products诱导卵巢切除雌性大鼠尾椎退变
Xiao Liang,Zhaohui Li,Pengcheng Ren et al.
Xiao Liang et al.
Background: Preclinical animal models are indispensable for the development of new therapeutic strategies and the study of the pathological mechanisms of intervertebral disc (IVD) degeneration (IVDD). This study aims to d...
A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration [0.03%]
横断面组织转录组-wide关联研究鉴定出椎间盘退变的易感基因
Li Zhang,Wen Zhao,Hongsheng Yang et al.
Li Zhang et al.
Background: Intervertebral disc degeneration (IDD) is a prevalent spinal condition frequently associated with pain and motor impairment, imposing a substantial burden on quality of life. Despite extensive investigations i...
TRIM25-Mediated Ubiquitination and Degradation of SOX8 Promotes Ligament Fibroblast Osteogenic Differentiation and Regulates OPLL Progression by Inhibiting OSR2 Transcription [0.03%]
TRIM25介导的SOX8泛素化降解促进韧带纤维细胞成骨分化并通过抑制OSR2转录调控 ossification of the posterior longitudinal ligament进展
Zhenqiang Wang,Yifan Tang,Changjiang Gu et al.
Zhenqiang Wang et al.
Background: Ossification of the posterior longitudinal ligament (OPLL) is a pathological condition characterized by ectopic ossification of spinal ligaments, primarily driven by abnormal osteogenic differentiation of liga...
Wharton's Jelly Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System [0.03%]
惠特克凝胶间充质基质细胞源性外泌体通过三维共培养系统减轻炎症应激下椎间盘退变
Veronica Tilotta,Gianluca Vadalà,Giuseppina Di Giacomo et al.
Veronica Tilotta et al.
This study explores the therapeutic potential of extracellular vesicles (EVs) derived from Wharton's Jelly mesenchymal stem cells in an in vitro 3D model of intervertebral disc degeneration under inflammatory stress. The treatment with WJ-M...
Quantitative Sensory Testing in an Observational Cohort of Adults With Chronic Low Back Pain [0.03%]
成人慢性下腰痛队列的感觉定量检测评估
Michael J Schneider,Carol M Greco,Amanda M Acevedo et al.
Michael J Schneider et al.
Background: Quantitative Sensory Testing (QST), also known as psychophysical testing, includes standardized methods for assessing humans' perceptions of different types of sensory stimuli and their associated pain thresho...
Biological Sex Is Under-Reported in Cartilage-Related Preclinical Research: A Cross-Sectional Analysis [0.03%]
软骨相关基础研究中生物学性别的报告不足：横断面分析
Daniele Zuncheddu,Paola Buedo,Martin J Stoddart et al.
Daniele Zuncheddu et al.
Background: Intervertebral disc degeneration (IDD) and osteoarthritis (OA) share many similarities in the molecular processes involved in the onset and progression of these musculoskeletal pathologies. Biological sex is a...
A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain [0.03%]
天然毒素和毒液中肽阻滞剂的理论回顾及其在慢性下背痛治疗中的应用
James Melrose,Stone Sima,Neha Chopra et al.
James Melrose et al.
Background: One of the significant putative causes of low back pain (LBP) is degeneration of the intervertebral disc (IVD). Degenerated discs exhibit loss of proteoglycans, notably aggrecan, leading to mechanical dysfunct...
Relationship Between Quantitative MRI and Radiological, Histological, and Biochemical Measures of Intervertebral Disc Health in Client-Owned, Nonchondrodystrophic-Breed Dogs [0.03%]
定量磁共振成像与客户拥有的非软骨发育不良犬种椎间盘健康放射学、组织学和生化测量之间的关系
Alaina L Falck,Erick O Buko,Kayla L Chase et al.
Alaina L Falck et al.
Background: Client-owned dogs presenting clinically with intervertebral disc disease (IVDD) are a potential comparative animal model to help advance the understanding of disc degeneration and its treatment. To utilize dog...
Patient-Reported Outcomes Among an Observational Cohort of Individuals With Chronic Low Back Pain [0.03%]
慢性下腰痛患者的结局指标：观察性队列中的结果分析
Carol M Greco,Nathan E Dodds,Amanda M Acevedo et al.
Carol M Greco et al.
Background: Chronic low back pain (cLBP) is complex, disabling, and costly to patients and to society. Patients' social circumstances, beliefs, and behaviors interact in a dynamic way with biomedical factors and have the ...
Comments on "Exploring the Therapeutic Potential of Puerarin on Intervertebral Disc Degeneration by Regulating Apoptosis of Nucleus Pulposus Cells" [0.03%]
有关“探究地奥茋治疗椎间盘退变的作用机制及对髓核细胞凋亡的调控作用”的几点评论
Ji Jin,Miao Liu,Jiajie Guo et al.
Ji Jin et al.
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JOR spine. 2025 Aug 12;8(3):e70099. DOI:10.1002/jsp2.70099 2025