Non-Uniform Electric Field Manipulation of Chromogenic Peptide Amphiphile Assemblies [0.03%]
非均匀电场对显色肽 amphiphile 聚集物的操控研究
Kiara L Lacy,Sujeung Lim,Emil M Lundqvist et al.
Kiara L Lacy et al.
This work investigates the influence of dielectrophoretic forces on the structural features and the resulting aggregates of a chromogenic model system, peptide-diacetylene (D3GV-DA) amphiphiles. Here, we systematically investigate how non-u...
Aqueous Synthesis of Membrane Lipids via Amide Formation between Amphiphilic Amines and Thioacids [0.03%]
两亲性胺与硫化物的酰胺反应制备膜脂质的水相合成法
Jiyue Chen,Lalita Tanwar,Peng Ji et al.
Jiyue Chen et al.
Protocell membranes were likely formed through primitive metabolic reactions that synthesized more complex membrane lipid species from simpler precursors. Thioacids have been shown to be prebiotically plausible and chemoselective N-acylatin...
Emergence of ATP- and GTP-Binding Aptamers from Single RNA Sequences by Error-Prone Replication and Selection [0.03%]
错配复制和选择产生ATP和GTP结合适配子的单链RNA序列
Falk Wachowius,Benjamin T Porebski,Christopher M Johnson et al.
Falk Wachowius et al.
The spontaneous emergence of function from diverse RNA sequence pools is widely considered an important transition in the origin of life. Here we show that diverse sequence pools are not a prerequisite for the emergence of function. Startin...
An Exploration of Multiple Component Peptide Assemblies by Enzyme-Instructed Self-Assembly [0.03%]
基于酶触发的多肽自组装体系用于探讨氨基酸侧链对自组装行为的影响及多组分肽的自组装行为探究
Adrianna N Shy,Jiashu Xu,Beom Jin Kim et al.
Adrianna N Shy et al.
Based on the motifs (RNISY (M) and DEEVELILGDT (D)) in the protein crystal structures of Merlin and CRL4DCAF-1, we phosphorylated the tyrosine residue in M and conjugated M to a self-assembling motif to produce a phosphopeptide (1P) and exa...
Direct quantification of ligand-induced lipid and protein microdomains with distinctive signaling properties [0.03%]
直接量化具有不同信号特性的配体诱导的脂质和蛋白质微域
Daniel Wirth,Michael D Paul,Elena B Pasquale et al.
Daniel Wirth et al.
Lipid rafts are ordered lipid domains that are enriched in saturated lipids, such as the ganglioside GM1. While lipid rafts are believed to exist in cells and to serve as signaling platforms through their enrichment in signaling components,...
Falk Wachowius,Philipp Holliger
Falk Wachowius
Central to the "RNA world" hypothesis of the origin of life is the emergence of an RNA catalyst capable of RNA replication. However, possible replicase ribozymes are quite complex and were likely predated by simpler non-enzymatic replicatio...