An Analysis of Different Distance-Linkage Methods for Clustering Gene Expression Data and Observing Pleiotropy: Empirical Study [0.03%]
聚类基因表达数据和观察多效性的不同距离联接方法分析：实证研究
Joydhriti Choudhury,Faisal Bin Ashraf
Joydhriti Choudhury
Background: Large amounts of biological data have been generated over the last few decades, encouraging scientists to look for connections between genes that cause various diseases. Clustering illustrates such a relations...
Mutational Patterns Observed in SARS-CoV-2 Genomes Sampled From Successive Epochs Delimited by Major Public Health Events in Ontario, Canada: Genomic Surveillance Study [0.03%]
在重大公共卫生事件期间采样获得的加拿大多伦多新冠病毒基因组突变图谱：一项基于基因组的研究监视研究
David Chen,Gurjit S Randhawa,Maximillian Pm Soltysiak et al.
David Chen et al.
Background: The emergence of SARS-CoV-2 variants with mutations associated with increased transmissibility and virulence is a public health concern in Ontario, Canada. Characterizing how the mutational patterns of the SAR...
Differential Expression of Long Noncoding RNAs in Murine Myoblasts After Short Hairpin RNA-Mediated Dysferlin Silencing In Vitro: Microarray Profiling [0.03%]
短发夹RNA沉默肌肉前体细胞中致死性肌营养不良基因DYSF后差异表达的长链非编码RNAs的微阵列分析
Richa Singhal,Rachel Lukose,Gwenyth Carr et al.
Richa Singhal et al.
Background: Long noncoding RNAs (lncRNAs) are noncoding RNA transcripts greater than 200 nucleotides in length and are known to play a role in regulating the transcription of genes involved in vital cellular functions. We...
Prediction of Antibody-Antigen Binding via Machine Learning: Development of Data Sets and Evaluation of Methods [0.03%]
基于机器学习的抗体-抗原结合预测：数据集的开发与方法评估
Chao Ye,Wenxing Hu,Bruno Gaeta
Chao Ye
Background: The mammalian immune system is able to generate antibodies against a huge variety of antigens, including bacteria, viruses, and toxins. The ultradeep DNA sequencing of rearranged immunoglobulin genes has consi...
User and Usability Testing of a Web-Based Genetics Education Tool for Parkinson Disease: Mixed Methods Study [0.03%]
帕金森病的网络遗传教育工具用户及使用体验测试：混合研究方法研究
Noah Han,Rachel A Paul,Tanya Bardakjian et al.
Noah Han et al.
Background: Genetic testing is essential to identify research participants for clinical trials enrolling people with Parkinson disease (PD) carrying a variant in the glucocerebrosidase (GBA) or leucine-rich repeat kinase ...
Convolutional Neural Network-Based Automatic Classification of Colorectal and Prostate Tumor Biopsies Using Multispectral Imagery: System Development Study [0.03%]
基于卷积神经网络的结直肠和前列腺肿瘤活检多光谱图像自动分类系统研发研究
Remy Peyret,Duaa alSaeed,Fouad Khelifi et al.
Remy Peyret et al.
Background: Colorectal and prostate cancers are the most common types of cancer in men worldwide. To diagnose colorectal and prostate cancer, a pathologist performs a histological analysis on needle biopsy samples. This m...
Diagnosis of a Single-Nucleotide Variant in Whole-Exome Sequencing Data for Patients With Inherited Diseases: Machine Learning Study Using Artificial Intelligence Variant Prioritization [0.03%]
基于人工智能变异优先级划分的机器学习研究在全外显子组测序数据中诊断遗传病患者的单核苷酸变异
Yu-Shan Huang,Ching Hsu,Yu-Chang Chune et al.
Yu-Shan Huang et al.
Background: In recent years, thanks to the rapid development of next-generation sequencing (NGS) technology, an entire human genome can be sequenced in a short period. As a result, NGS technology is now being widely intro...
It Is in Our DNA: Bringing Electronic Health Records and Genomic Data Together for Precision Medicine [0.03%]
精准医疗：电子健康记录与基因组数据的融合已经刻在我们的DNA里
Alan J Robertson,Andrew J Mallett,Zornitza Stark et al.
Alan J Robertson et al.
Health care is at a turning point. We are shifting from protocolized medicine to precision medicine, and digital health systems are facilitating this shift. By providing clinicians with detailed information for each patient and analytic sup...
Mara Thomas,Nuria Mackes,Asad Preuss-Dodhy et al.
Mara Thomas et al.
Background: Genetic data are widely considered inherently identifiable. However, genetic data sets come in many shapes and sizes, and the feasibility of privacy attacks depends on their specific content. Assessing the rei...
The Identification of Potential Drugs for Dengue Hemorrhagic Fever: Network-Based Drug Reprofiling Study [0.03%]
基于网络的药物再定位研究识别登革出血热潜在药物
Praveenkumar Kochuthakidiyel Suresh,Gnanasoundari Sekar,Kavya Mallady et al.
Praveenkumar Kochuthakidiyel Suresh et al.
Background: Dengue fever can progress to dengue hemorrhagic fever (DHF), a more serious and occasionally fatal form of the disease. Indicators of serious disease arise about the time the fever begins to reduce (typically ...