Unpacking Genomic Biomarkers for Programmed Cell Death Receptor-1 Immunotherapy Success in Non-Small Cell Lung Cancer Using Deep Neural Networks: Quantitative Study [0.03%]
基于深度神经网络的非小细胞肺癌程序性死亡受体-1免疫疗法成功类基因组生物标志物的研究：量化研究
Rayan Mubarak,Fahim Islam Anik,Jean T Rodriguez et al.
Rayan Mubarak et al.
Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality. Programmed cell death receptor-1 (PD-1) immunotherapy has shown results in the treatment of NSCLC; however, not all ...
Systematic Mining of Bioactive Compounds for Wound Healing From Cayratia Japonica Exosome-Like Nanovesicles: A Workflow Combining LC-MS and DeepSeek Models [0.03%]
基于Cayratia japonica外泌体-like纳米囊泡的伤口愈合活性化合物的系统筛选：结合LC-MS和DeepSeek模型的工作流程
Qiang Fu,Wei Ji,Yu-Ping Fan et al.
Qiang Fu et al.
Background: Plant-derived exosome-like nanovesicles (P-ELNs) effectively deliver bioactive compounds due to their high biocompatibility and low immunogenicity. While liquid chromatography-mass spectrometry (LC-MS) profile...
Development and Validation of a Generative Artificial Intelligence-Based Pipeline for Automated Clinical Data Extraction From Electronic Health Records: Technical Implementation Study [0.03%]
基于生成式人工智能的电子健康记录临床数据自动提取管道的发展与验证：技术实施研究
Marvin N Carlisle,William A Pace,Andrew W Liu et al.
Marvin N Carlisle et al.
Background: The manual abstraction of unstructured clinical data is often necessary for granular clinical outcomes research but is time consuming and can be of variable quality. Large language models (LLMs) show promise i...
Correction: Structural and Functional Impacts of SARS-CoV-2 Spike Protein Mutations: Insights From Predictive Modeling and Analytics [0.03%]
关于SARS-CoV-2刺突蛋白突变的结构和功能影响的更正：来自预测建模和分析的见解
Edem K Netsey,Samuel M Naandam,Joseph Asante Jnr et al.
Edem K Netsey et al.
Structural and Functional Impacts of SARS-CoV-2 Spike Protein Mutations: Insights From Predictive Modeling and Analytics [0.03%]
SARS-CoV-2刺突蛋白突变的结构和功能影响：来自预测建模和分析的见解
Edem K Netsey,Samuel M Naandam,Joseph Asante Jnr et al.
Edem K Netsey et al.
Background: The COVID-19 pandemic requires a deep understanding of SARS-CoV-2, particularly how mutations in the spike receptor-binding domain (RBD) chain E affect its structure and function. Current methods lack comprehe...
Immunogenicity of Adalimumab in Bacterial Molecular Mimicry: In Silico Analysis [0.03%]
阿达木单抗细菌分子模拟的免疫原性：基于计算机的分析
Diana Isabel Pachón-Suárez,Germán Mejía-Salgado,Oscar Correa et al.
Diana Isabel Pachón-Suárez et al.
Background: Adalimumab, a monoclonal antibody targeting tumor necrosis factor α, treats autoimmune diseases but induces antidrug antibodies in 30% to 60% of patients, reducing its efficacy. ...
Paired-Sample and Pathway-Anchored MLOps Framework for Robust Transcriptomic Machine Learning in Small Cohorts: Model Classification Study [0.03%]
针对小型队列的稳健转录组机器学习的配对样本和通路锚定MLOps框架：模型分类研究
Mahdieh Shabanian,Nima Pouladi,Liam Wilson et al.
Mahdieh Shabanian et al.
Background: Approximately 90% of the 65,000 human diseases are infrequent, collectively affecting ~400 million people, substantially limiting cohort accrual. This low prevalence constrains the development of robust transc...
Systemic Anticancer Therapy Timelines Extraction From Electronic Medical Records Text: Algorithm Development and Validation [0.03%]
电子健康记录文本中提取系统抗癌治疗时间线的算法开发和验证
Jiarui Yao,Eli Goldner,Harry Hochheiser et al.
Jiarui Yao et al.
Background: The systemic treatment of cancer typically requires the use of multiple anticancer agents in combination or sequentially. Clinical narrative texts often contain extensive descriptions of the temporal sequencin...
Optimizing Feature Selection and Machine Learning Algorithms for Early Detection of Prediabetes Risk: Comparative Study [0.03%]
一种用于早期发现糖尿病前期风险的特征选择和机器学习算法优化方法：比较研究
Mahmoud B Almadhoun,M A Burhanuddin
Mahmoud B Almadhoun
Background: Prediabetes is an intermediate stage between normal glucose metabolism and diabetes and is associated with increased risk of complications like cardiovascular disease and kidney failure. ...
Protein-Protein Interactions in Papillary and Nonpapillary Urothelial Carcinoma Architectures: Comparative Study [0.03%]
乳头状和非乳头状尿路上皮瘤结构中的蛋白质-蛋白质相互作用：比较研究
Charissa Chou,Yiğit Baykara,Sean Hacking et al.
Charissa Chou et al.
Background: Bladder cancer is a disease characterized by complex perturbations in gene networks and is heterogeneous in terms of histology, mutations, and prognosis. Advances in high-throughput sequencing technologies, ge...