High CCR6 expression increases the risk of pediatric Langerhans cell histiocytosis [0.03%]
CCR6高表达增加儿童郎格汉斯细胞组织细胞增生症的风险
Xingfeng Yao,Yutian Zheng,Jiasi Xia et al.
Xingfeng Yao et al.
Langerhans cell histiocytosis (LCH) is a rare disorder that primarily affects children. Considering the intricate clinical presentation of this disease, the identification of specific biomarkers associated with susceptibility to LCH is esse...
Superiority of allo-SCT to auto-SCT in high-risk T-cell lymphoblastic lymphoma/leukemia patients with aaIPI ≥3: insights from a retrospective, multicenter analysis [0.03%]
高危T细胞淋巴母细胞淋巴瘤/白血病(aaIPI≥3)患者allo-SCT治疗较auto-SCT更优：一项基于回顾性、多中心分析的见解
Xiaodan Luo,Zhiping Fan,Runhui Zheng et al.
Xiaodan Luo et al.
High recurrence is a major challenge in treating T-lymphoblastic lymphoma (T-LBL). Allogeneic (allo-) or autologous (auto-) stem cell transplantation (SCT) is recommended to reduce relapse, though the optimal choice remains unclear. This st...
Yingjin Zhang,Changwen Xue,Chao Wu et al.
Yingjin Zhang et al.
The use of cytarabine (Ara-C) in treating acute promyelocytic leukemia (APL) is controversial. This study was conducted to demonstrate the effect of treatment with or without Ara-C on long-term event-free survival (EFS) or overall survival ...
Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases [0.03%]
综合性生物信息学分析开发慢性增生性疾病的恶性转化诊断模型
Hua Liu,Sheng Lin,Pei-Xuan Chen et al.
Hua Liu et al.
The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated w...
Prognostic impact of co-mutations in adults with IDH1/2-mutated acute myeloid leukemia [0.03%]
IDH1/2突变型成人急性髓系白血病的共突变预后影响
Anli Lai,Wenbing Liu,Chunlin Zhou et al.
Anli Lai et al.
Acute myeloid leukemia (AML) is characterized by the accumulation of cytogenetic and molecular abnormalities. Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations occur in 11% to 20% of adults with AML. The outcome of IDH1/2-mutated AML is h...
Stem cell transplantation indications for patients with acute leukemia determined by measurable residual disease: what we know and what we do not know [0.03%]
可测量的残留疾病确定急性白血病患者进行干细胞移植的指征：已知和未知的内容
Xiao-Su Zhao,Xiao-Tong Chen,Ying-Jun Chang
Xiao-Su Zhao
Acute leukemia (AL), which includes acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), is a hematological malignancy characterized by the uncontrolled proliferation of immature myeloid or lymphoid cells. Allogeneic stem ce...
Erythroblastic island: the niche for erythroid terminal differentiation and beyond [0.03%]
红系岛：红系终末分化的生态位及展望
Lingyue Zheng,Jingwei Wang,Xu Jin et al.
Lingyue Zheng et al.
The erythroblastic island (EBI) is a multicellular structure defined by the presence of 1 or 2 central macrophages surrounded by at least 3 erythroblasts. EBIs were initially proposed as a specialized microenvironment exclusively for erythr...
Qiaoyi Zhou,Ying Wang
Qiaoyi Zhou
Lineage switch is a rare phenomenon in which acute myeloid leukemia (AML) transforms into acute lymphoblastic leukemia (ALL) and vice versa, sharing the same clonal origin. It is more common for AML to relapse as ALL. Cytogenetics, microenv...
Challenging the prognostic expectations: a rare case of ZNF618:: NUTM1-positive B-cell lymphoblastic leukemia with poor outcome [0.03%]
挑战预后期望：一例罕见的ZNF618::NUTM1阳性B细胞淋巴母细胞白血病伴不良结局
Xue Chen,Lili Yuan,Xiaoli Ma et al.
Xue Chen et al.
Multi-omics integration reveals immune hallmarks and biomarkers associated with FLT3 inhibitor sensitivity in FLT3-mutated AML [0.03%]
多组学整合揭示与FLT3突变型AML中FLT3抑制剂敏感性相关的免疫标志物和生物标志物
Mingming Niu,Ning Wang,Dandan Yang et al.
Mingming Niu et al.
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by poor clinical outcomes, frequently exacerbated by mutations in the FMS-like tyrosine kinase 3 (FLT3) gene. Although FLT3 inhibitors (FLT3i) have emerged a...