Breakthroughs and challenges of CAR-T cell therapy in treating hematologic malignancies of the central nervous system [0.03%]
CAR-T细胞治疗中枢神经系统血液系统恶性肿瘤的突破与挑战
Xiaoning Li,Haili Da,Jie Zhao et al.
Xiaoning Li et al.
Chimeric antigen receptor T (CAR-T) cell therapy has transformed hematologic cancer treatment; however, its application in patients with central nervous system (CNS) involvement remains challenging because of exclusion from key trials. Rece...
Allogeneic hematopoietic stem cell transplantation combined with dasatinib successfully treated adult acute lymphoblastic leukemia with e1a3 BCR-ABL1 fusion gene positivity: a case report and literature review [0.03%]
异基因造血干细胞移植联合达沙替尼成功治疗成人E1A3BCR-ABL1融合基因阳性急性淋巴细胞白血病1例及相关文献复习
Wenhui Liu,Tao Wu,Yang Liu et al.
Wenhui Liu et al.
ITP, easy as EBV: a rare case of severe immune thrombocytopenic purpura secondary to Epstein-Barr virus [0.03%]
EB病毒继发的严重免疫性血小板减少症的罕见案例：EB病毒导致免疫性血小板减少综合征(ITP)病例报告
Christopher Simon Hanna,Ramzi Hamouche,Shea-Lee Godin et al.
Christopher Simon Hanna et al.
Zanubrutinib enhances CD19 CAR T killing of B-cell lymphoma by inhibiting BTK phosphorylation, regulating PI3K/AKT/mTOR pathway, and promoting autophagy [0.03%]
赞布替尼通过抑制BTK磷酸化、调节PI3K/AKT/mTOR途径和促进自噬来增强CD19 CAR T对B细胞淋巴瘤的杀伤作用
Hao Yao,Ling Qiu,Shi-Hui Ren et al.
Hao Yao et al.
Anti-CD19 chimeric antigen receptor T cells (CAR T) still have many limitations, including insufficient clinical efficacy. Zanubrutinib is a second-generation Bruton tyrosine kinase (BTK) inhibitor with higher drug potency, and it is not cl...
Application of next-generation sequencing in the treatment of myelodysplastic syndrome: from mechanisms to clinical practice [0.03%]
下一代测序技术在骨髓增生异常综合征治疗中的应用：从机制到临床实践
Ying-Ying Ma,Cheng Zhang,Ying Chen et al.
Ying-Ying Ma et al.
Myelodysplastic syndrome (MDS) is a malignant clonal disorder originating from hematopoietic stem and progenitor cells and is characterized by ineffective hematopoiesis and a high propensity for transformation into acute leukemia. Research ...
Identification of two novel TP53 mutations in secondary acute myeloid leukemia following multiple myeloma: a case report [0.03%]
继发性急性髓系白血病伴两个新型TP53突变的病例报告——多发性骨髓瘤后的并发症
Maria Antonia De Francesco,Rossella Ribolla,Alessandra Sottini et al.
Maria Antonia De Francesco et al.
Mengke Zhang,Changya Chen
Mengke Zhang
Single-cell chromatin accessibility analysis enables high-resolution dissection of regulatory elements and gene regulatory mechanisms. However, standardized and comprehensive analysis workflows remain limited. In this study, we present a st...
Anti-thymocyte globulin-resistant CD4+ memory T cells contribute to haplo-fever after allogeneic hematopoietic stem cell transplantation [0.03%]
抗胸腺细胞球蛋白耐药的CD4+记忆T细胞参与allo-发热性疾病后异基因造血干细胞移植
Huihong Huang,Ting Lu,Honglin Duan et al.
Huihong Huang et al.
Haplo-fever (HF) is a form of non-infectious fever that occurs shortly after haploidentical (HID) hematopoietic stem cell transplantation (HSCT). Its clinical significance, risk factors, and pathophysiology, particularly in the context of a...
Novel gene variants in a rare case of SRY-negative 46, XX male syndrome with bone marrow failure by whole exome sequencing [0.03%]
全外显子组测序发现的一种罕见SRY阴性46,XX男性综合征病例中的新型基因变异
Aoli Zhang,Lipeng Liu,Min Ruan et al.
Aoli Zhang et al.